Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | Ribavirin | 15300.211 | uM | 48.18310 | 61.54250 | 0.4912 | -0.1113 | 0.8215 | 0.1121 | 0.6468 | 0.8961 | |||
| Hs 578T | TNBC | Basal B | Chloroquine | 12622.177 | uM | 5.16760 | 8.74240 | -0.6678 | -0.7210 | 1.6981 | 0.2810 | 0.9997 | 2.5433 | |||
| EFM-192B | HER2amp | Luminal | Ribavirin | 15387.211 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0048 | -0.0190 | 1.2404 | |||
| MDA-MB-134-VI | HR+ | Luminal | 2-deoxyglucose | 12662.177 | uM | inf | inf | 0.9676 | 0.9676 | 0.0000 | 0.0405 | 0.0000 | 1.7065 | |||
| MDA-MB-175-VII | HR+ | Luminal | Nelfinavir | 13754.174 | uM | 6.54890 | 9.60220 | -0.9753 | -1.0000 | 2.8707 | 0.3702 | 0.8599 | 0.4290 | |||
| HCC1187 | TNBC | Basal A | Torkinib | 15300.211 | uM | 0.00035 | 0.03423 | -0.7443 | -1.0000 | 0.2401 | 1.0888 | 0.9649 | 0.8961 | |||
| SUM1315MO2 | TNBC | Basal B | Torkinib | 15401.211 | uM | -inf | 0.00012 | -0.9603 | -0.8964 | 0.4331 | 1.6631 | 0.9588 | 0.4079 | |||
| MCF12A | NM | Basal B | Torkinib | 15354.211 | uM | 0.04264 | 0.06448 | -0.0330 | -0.0815 | 0.3654 | 0.5526 | 0.9840 | 2.0320 | |||
| MDA-MB-453 | TNBC | Luminal | Methylglyoxal | 13647.184 | uM | inf | inf | -0.8749 | -0.8749 | 0.0000 | 0.3852 | 0.4269 | 1.2942 | |||
| MDA-MB-415 | HR+ | Luminal | Mebendazole | 12959.174 | uM | 0.37016 | 5.03160 | -0.2608 | -0.8222 | 0.3727 | 0.5042 | 0.9457 | 0.5020 | |||
| HCC2185 | TNBC | Luminal | Torkinib | 15306.211 | uM | 0.00017 | 0.00130 | -0.8220 | -0.8191 | 0.4777 | 1.4061 | 0.9962 | 0.4935 | |||
| HCC38 | TNBC | Basal B | Methylglyoxal | 13635.184 | uM | inf | inf | -0.7403 | -0.7403 | 0.0000 | 0.4439 | 0.5429 | 1.5062 | |||
| HCC1143 | TNBC | Basal A | Chloroquine | 13099.177 | uM | inf | inf | -0.9999 | -0.9999 | 0.0000 | 0.7050 | 0.1850 | 0.7419 | |||
| MDA-MB-415 | HR+ | Luminal | Nelfinavir | 13587.174 | uM | 6.20260 | 9.49140 | -0.9727 | -1.0000 | 2.5824 | 0.2550 | 0.9695 | 0.6955 | |||
| MDA-MB-415 | HR+ | Luminal | Mebendazole | 13587.174 | uM | 0.32163 | 0.37879 | -0.2050 | -0.1694 | 1.7834 | 0.5079 | 0.9728 | 0.6955 | |||
| MDA-MB-453 | TNBC | Luminal | Nelfinavir | 13562.174 | uM | 9.50690 | 8.91340 | 0.1303 | 0.1283 | 4.5978 | 0.0948 | 0.9810 | 0.7219 | |||
| MDA-MB-415 | HR+ | Luminal | Nelfinavir | 12959.174 | uM | 5.04820 | 9.28020 | -0.8963 | -1.0000 | 1.8044 | 0.3326 | 0.9326 | 0.5020 | |||
| MDA-MB-453 | TNBC | Luminal | Nelfinavir | 12964.174 | uM | 5.03420 | 8.04630 | -0.9964 | -1.0000 | 2.3427 | 0.2872 | 0.9802 | 0.7885 | |||
| HCC1143 | TNBC | Basal A | Mebendazole | 13099.174 | uM | 0.87433 | 2.73210 | -0.2007 | -0.3902 | 0.5063 | 0.3895 | 0.9656 | 0.9441 | |||
| BT-20 | TNBC | Basal A | Torkinib | 15385.211 | uM | 0.00007 | 0.00943 | -0.7410 | -0.9904 | 0.2213 | 1.1960 | 0.990 | 0.7321 | |||
| HCC70 | TNBC | Basal A | Nelfinavir | 12714.174 | uM | 8.95410 | 11.15450 | -1.0000 | -1.0000 | 5.0000 | 0.3201 | 0.8734 | 0.3306 | |||
| 21MT-1 | HER2amp | - | Mebendazole | 13719.174 | uM | 31.97060 | 77.55140 | 0.0875 | -1.0000 | 1.2398 | 0.1610 | 0.8782 | 0.8124 | |||
| 21MT-1 | HER2amp | - | Methylglyoxal | 13719.184 | uM | 680.32080 | 999.99990 | -0.9954 | -0.9645 | 2.7899 | 0.6345 | 0.9961 | 0.7600 |