Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | 2-deoxyglucose | 12622.177 | uM | 837.94870 | 677.66110 | 0.3271 | 0.3269 | 4.9962 | 0.0868 | 0.9950 | 2.5433 | |||
| MCF 10A | NM | Basal B | 2-deoxyglucose | 12944.177 | uM | 930.49390 | 1000.00000 | 0.0911 | -0.0492 | 1.3017 | 0.1223 | 0.9135 | 2.0477 | |||
| HCC38 | TNBC | Basal B | 2-deoxyglucose | 12617.177 | uM | 243.13950 | 257.10010 | 0.0218 | -0.0338 | 1.1705 | 0.2324 | 0.9921 | 1.6822 | |||
| LY2 | HR+ | Luminal | Methylglyoxal | 13639.184 | uM | inf | inf | -0.8274 | -0.8274 | 0.0000 | 0.3747 | 0.4895 | 1.5976 | |||
| MCF7 | HR+ | Luminal | 2-deoxyglucose | 12657.177 | uM | inf | 999.99930 | 0.6366 | 0.6079 | 2.0818 | 0.0688 | 0.8695 | 0.9257 | |||
| MDA-MB-415 | HR+ | Luminal | Chloroquine | 12959.177 | uM | 5.27820 | 10.03080 | -0.9994 | -1.0000 | 1.7110 | 0.4009 | 0.9371 | 0.5538 | |||
| MDA-MB-415 | HR+ | Luminal | 2-deoxyglucose | 12959.177 | uM | inf | inf | 0.3997 | 0.3997 | 0.0000 | 0.1758 | 0.1401 | 0.5538 | |||
| EFM-192B | HER2amp | Luminal | Ribavirin | 15288.211 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0002 | -0.0013 | 0.9250 | |||
| LY2 | HR+ | Luminal | Nelfinavir | 12627.174 | uM | 8.39840 | 12.76790 | -0.8520 | -1.0000 | 2.6227 | 0.1651 | 0.9984 | 1.3419 | |||
| SUM185PE | TNBC | Luminal | Torkinib | 15332.211 | uM | 1.12310 | 1.43350 | -0.1839 | -0.1860 | 1.2957 | 0.3381 | 0.9687 | 0.8413 | |||
| MX1 | Unknown | Unknown | Methylglyoxal | 13567.184 | uM | 468.21670 | 705.16970 | -0.9987 | -1.0000 | 2.6828 | 0.7669 | 0.9728 | 0.6921 | |||
| MDA-MB-157 | TNBC | Basal B | Torkinib | 15321.211 | uM | 0.03892 | 0.91831 | -0.4972 | -0.9420 | 0.3351 | 0.6929 | 0.9944 | 2.7437 | |||
| MCF12A | NM | Basal B | Mebendazole | 12949.174 | uM | 2.69550 | 4.30780 | 0.0553 | -0.1473 | 0.5507 | 0.2817 | 0.9795 | 1.9016 | |||
| MCF12A | NM | Basal B | Methylglyoxal | 13508.184 | uM | 576.52490 | 995.81850 | -0.8032 | -0.7829 | 1.7240 | 0.5701 | 0.9916 | 2.2235 | |||
| Hs 578T | TNBC | Basal B | Ribavirin | 15352.211 | uM | inf | inf | 0.9699 | 0.9699 | 0.0000 | -0.0304 | -0.7752 | 2.5357 | |||
| MX1 | Unknown | Unknown | Mebendazole | 12667.174 | uM | 0.32772 | 0.39909 | -0.3630 | -0.2626 | 2.1427 | 0.4878 | 0.9911 | 0.8129 | |||
| HCC1937 | TNBC | Basal A | Methylglyoxal | 13177.184 | uM | 504.29230 | 687.61710 | -1.0000 | -1.0000 | 3.5430 | 0.6770 | 0.9873 | 0.3394 | |||
| EFM-192B | HER2amp | Luminal | Torkinib | 15288.211 | uM | 0.00137 | 0.00325 | -0.6816 | -0.5670 | 0.8789 | 1.1523 | 0.9810 | 0.9250 | |||
| HCC38 | TNBC | Basal B | Torkinib | 15351.211 | uM | 0.00026 | 0.00145 | -0.9254 | -0.8879 | 0.5960 | 1.4733 | 0.9779 | 1.0866 | |||
| MCF7 | HR+ | Luminal | Torkinib | 15394.211 | uM | 0.00006 | 0.00015 | -0.2414 | -0.2040 | 0.3606 | 1.0163 | 0.9695 | 1.8299 | |||
| SUM190PT | HER2amp | Luminal | Ribavirin | 15358.211 | uM | inf | inf | 1.0036 | 1.0036 | 0.0000 | -0.0073 | -0.0327 | 1.3504 | |||
| SUM190PT | HER2amp | Luminal | Torkinib | 15358.211 | uM | 0.12352 | 0.43018 | -0.6414 | -0.6618 | 0.6757 | 0.6069 | 0.9927 | 1.3504 | |||
| HCC2185 | TNBC | Luminal | Ribavirin | 15306.211 | uM | inf | inf | 0.9179 | 0.9179 | 0.0000 | 0.0789 | 0.0000 | 0.4935 | |||
| MCF12A | NM | Basal B | Nelfinavir | 12949.174 | uM | 25.91070 | 85.74380 | 0.3987 | -1.0000 | 0.9180 | 0.0971 | 0.8818 | 1.9016 | |||
| MDA-MB-157 | TNBC | Basal B | Chloroquine | 12632.177 | uM | 1.67050 | 3.57270 | -0.9971 | -1.0000 | 1.4452 | 0.4610 | 0.9970 | 0.6753 |