Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | Ribavirin | 15398.211 | uM | inf | inf | 0.8982 | 0.8982 | 0.0000 | 0.0145 | 0.1417 | 1.0628 | |||
| T47D | HR+ | Luminal | Torkinib | 15340.211 | uM | 0.00038 | 0.00069 | -0.2049 | -0.1299 | 0.3943 | 0.8877 | 0.9641 | 1.5685 | |||
| MDA-MB-134-VI | HR+ | Luminal | Ribavirin | 15355.211 | uM | inf | inf | 0.9510 | 0.9510 | 0.0000 | 0.1174 | 0.0035 | 1.0584 | |||
| SUM52PE | HR+ | Luminal | Methylglyoxal | 13651.184 | uM | inf | inf | -0.6727 | -0.6727 | 0.0000 | 0.8697 | 0.5569 | 0.7406 | |||
| SUM159PT | TNBC | Basal B | Mebendazole | 13004.174 | uM | 0.25791 | 0.33026 | -0.1743 | -0.1821 | 1.2558 | 0.5096 | 0.9921 | 3.2757 | |||
| T47DKBLUC | Unknown | Unknown | Ribavirin | 15360.211 | uM | 64.03520 | 55.15130 | 0.7199 | 0.2630 | 4.9988 | -0.0057 | 0.8112 | 0.8772 | |||
| 21NT | HER2amp | - | Methylglyoxal | 13653.184 | uM | 371.60 | 1000.00000 | -0.9322 | -0.8591 | 1.0101 | 0.5941 | 0.9376 | 1.5871 | |||
| T47D | HR+ | Luminal | Methylglyoxal | 13623.184 | uM | 575.5230 | 599.38190 | -0.7988 | -0.1126 | 5.0000 | 0.5014 | 0.5757 | 1.1220 | |||
| SUM159PT | TNBC | Basal B | Methylglyoxal | 13054.184 | uM | 220.47610 | 301.56480 | -0.8767 | -0.7403 | 2.9008 | 0.8005 | 0.8788 | 2.8248 | |||
| UACC-812 | HER2amp | Luminal | Ribavirin | 15404.211 | uM | inf | inf | 0.5877 | 0.5877 | 0.0000 | 0.1644 | -0.0476 | 0.5754 | |||
| MCF 10F | NM | - | Mebendazole | 13750.174 | uM | 3.91920 | 96.55890 | -0.0155 | -1.0000 | 0.3429 | 0.2885 | 0.9278 | 1.4282 | |||
| UACC-812 | HER2amp | Luminal | Nelfinavir | 13078.174 | uM | inf | inf | 0.9914 | 0.9914 | 0.0000 | 0.0487 | 0.0000 | 0.6238 | |||
| EFM-192A | HER2amp | Luminal | Torkinib | 15284.211 | uM | 0.00167 | 0.00424 | -0.5970 | -0.4552 | 0.6957 | 1.0349 | 0.9758 | 0.8976 | |||
| T47DKBLUC | Unknown | Unknown | 2-deoxyglucose | 13070.177 | uM | inf | inf | 0.0803 | 0.0803 | 0.0000 | 0.5360 | 0.0445 | 0.9040 | |||
| EFM-19 | HR+ | Luminal | Torkinib | 15296.211 | uM | 0.00003 | 0.00091 | -0.4760 | -0.5739 | 0.2205 | 1.1055 | 0.9560 | 1.4068 | |||
| T47D | HR+ | Luminal | Ribavirin | 15340.211 | uM | inf | 11.53030 | 0.6704 | 0.6701 | 4.9483 | 0.0040 | 0.9110 | 1.5685 | |||
| MCF 10F | NM | - | Methylglyoxal | 13672.184 | uM | 325.82880 | 1000.00000 | -0.9500 | -0.9161 | 0.9284 | 0.6111 | 0.9793 | 2.3721 | |||
| SUM225CWN | HER2amp | Basal A | Torkinib | 15403.211 | uM | 0.02304 | 0.20245 | -0.6514 | -0.8008 | 0.4399 | 0.7911 | 0.9881 | 0.7553 | |||
| MCF 10F | NM | - | Nelfinavir | 13750.174 | uM | 9.41490 | 15.28370 | -0.7109 | -1.0000 | 2.2675 | 0.2028 | 0.9819 | 1.4282 | |||
| ZR-75-1 | HR+ | Luminal | 2-deoxyglucose | 12677.177 | uM | inf | inf | 0.3935 | 0.3935 | 0.0000 | 0.2078 | 0.3077 | 1.0515 | |||
| HCC38 | TNBC | Basal B | Chloroquine | 12617.177 | uM | 16.65350 | 26.89110 | -0.1723 | -0.4930 | 1.4319 | 0.1596 | 0.9857 | 1.6822 | |||
| SUM229PE | TNBC | - | Methylglyoxal | 13201.184 | uM | 535.45630 | 662.02810 | -0.9518 | -0.9445 | 4.9999 | 0.6502 | 0.9991 | 1.3314 | |||
| BT-483 | HR+ | Luminal | Mebendazole | 13130.174 | uM | 2.05160 | 1.15580 | 0.2836 | 0.0818 | 0.3113 | 0.3396 | 0.8145 | 0.5126 | |||
| UACC-812 | HER2amp | Luminal | Mebendazole | 13078.174 | uM | 4.07970 | 51.75050 | -0.1950 | -1.0000 | 0.4325 | 0.3427 | 0.5767 | 0.6238 | |||
| 21NT | HER2amp | - | Nelfinavir | 13575.174 | uM | 19.74930 | 24.7910 | -0.2090 | -0.6289 | 3.5820 | 0.0991 | 0.9947 | 1.5845 |