Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 11057.155 | uM | 54.25520 | 19.05870 | 0.4787 | 0.0885 | 0.1862 | 0.2584 | 0.9646 | 4.1614 | |
| SUM159PT | TNBC | Basal B | PD184352 | MEK | MAPK | 11057.155 | uM | 20.13750 | 999.99970 | 0.4189 | -0.5412 | 0.1878 | 0.2397 | 0.9353 | 4.1614 | |
| SUM159PT | TNBC | Basal B | PD184352 | MEK | MAPK | 11057.155 | uM | 20.13750 | 999.99970 | 0.4189 | -0.5412 | 0.1878 | 0.2397 | 0.9353 | 4.1614 | |
| SUM159PT | TNBC | Basal B | Dactolisib | PI3K | PI3K | 11057.155 | uM | 0.06495 | 0.04736 | 0.1337 | 0.1744 | 1.3579 | 0.4633 | 0.9158 | 4.1614 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 7920.05 | uM | inf | 0.02034 | 0.4715 | 0.5077 | 0.6584 | 0.2518 | 0.9823 | 4.1624 | |
| SUM159PT | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7920.05 | uM | 0.06950 | 0.07046 | -0.1466 | -0.0220 | 3.1217 | 0.5658 | 0.9871 | 4.1624 | |
| SUM159PT | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 11057.151 | uM | 1.55590 | 0.41918 | 0.3947 | 0.3852 | 1.1222 | 0.2144 | 0.9948 | 4.1698 | |
| SUM159PT | TNBC | Basal B | XRP44X | ELK3 | MAPK | 11057.151 | uM | 0.93403 | 0.78279 | 0.1565 | 0.2344 | 3.5803 | 0.3103 | 0.9477 | 4.1698 | |
| SUM159PT | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7920.016 | uM | 27.5070 | 43.54760 | 0.3380 | -0.8378 | 2.1423 | 0.0270 | 0.9777 | 4.3230 | |
| SUM159PT | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7920.016 | uM | inf | 147.84710 | 0.8503 | 0.7670 | 4.7960 | -0.0230 | 0.6294 | 4.3230 | ||
| SUM159PT | TNBC | Basal B | AG1478 | EGFR | ErbB | 7920.016 | uM | 25.90870 | 33.39040 | -0.2225 | -0.2898 | 1.8023 | 0.1605 | 0.9971 | 4.3230 | |
| SUM159PT | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7920.068 | uM | 4.68180 | 9.92620 | -0.2346 | -0.1745 | 0.3983 | 0.3470 | 0.6243 | 4.3418 | |
| SUM159PT | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7920.018 | uM | 0.01993 | 0.02096 | -0.2847 | -0.0483 | 1.8288 | 0.6036 | 0.9631 | 4.3723 | |
| SUM159PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7920.018 | uM | 640.18180 | 1000.00000 | -0.3159 | -0.3141 | 1.0931 | 0.2051 | 0.8249 | 4.3723 | ||
| SUM159PT | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7920.018 | uM | inf | inf | 0.9492 | 0.9492 | 0.0000 | 0.0108 | 0.4781 | 4.3723 | |
| SUM159PT | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7920.13 | uM | 6.34610 | 9.52020 | -0.3684 | -0.3475 | 1.3011 | 0.3473 | 0.9952 | 4.3955 | |
| SUM159PT | TNBC | Basal B | 5-FU | TYMS | TYMS | 7920.13 | uM | 130.24210 | 83.00670 | 0.1415 | 0.1407 | 0.7336 | 0.3613 | 0.9971 | 4.3955 | |
| SUM159PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 7920.001 | uM | 0.03320 | 0.02904 | 0.0820 | 0.0724 | 1.1683 | 0.5004 | 0.9949 | 4.4085 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 7920.001 | uM | 7.60870 | 32.44490 | -0.0516 | -1.0000 | 0.7575 | 0.1691 | 0.9522 | 4.4085 | |
| SUM159PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 7920.001 | uM | 0.04495 | 0.03755 | 0.0271 | 0.2029 | 2.8919 | 0.4024 | 0.9647 | 4.4085 | |
| SUM159PT | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7920.075 | uM | 9.39680 | 19.30080 | -0.2022 | -0.3465 | 0.7314 | 0.3790 | 0.9828 | 4.5785 | |
| SUM159PT | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7920.075 | uM | 0.03294 | 0.03077 | 0.0327 | 0.0670 | 2.1177 | 0.7312 | 0.9949 | 4.5785 | |
| SUM159PT | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7920.075 | uM | 70.40610 | 84.95560 | -0.2887 | -0.2931 | 2.4562 | 0.2851 | 0.9991 | 4.5785 |