Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
BT-549
TNBC
Basal B
 Cisplatin
DNA cross-linker
DNA cross-linker
7803.017
uM
3.6390
7.43850
 -0.7208 -0.7492 1.2807 0.4846
0.9996
 2.9572
BT-549
TNBC
Basal B
 Epirubicin
TOP2
TOP
7803.017
uM
0.20903
0.46305
 -0.8801 -0.7455 1.1474 0.8058
0.9886
 2.9572
BT-549
TNBC
Basal B
 GW-5074
CRAF
MAPK
5909.088
uM
inf
inf
 1.0500 1.0500 0.0000 -0.0255
-2.9579
 2.9659
MCF 10A
NM
Basal B
 Ribavirin
15392.211
uM
inf
1000.00000
 0.6244 0.0123 0.2385 0.1289
0.6395
 2.9667
MCF 10A
NM
Basal B
 Torkinib
15392.211
uM
0.09065
0.05717
 0.1059 0.1141 0.5621 0.4665
0.9882
 2.9667
BT-549
TNBC
Basal B
 NSC 663284
CDC25
CDC
12305.152
uM
1.60690
2.04520
 -0.8290 -0.7672 3.8550 0.6192
0.9945
 2.9694
BT-549
TNBC
Basal B
 PD 98059
MEK
MAPK
12305.152
uM
100.55160
728.49770
 0.6120 -1.0000 0.5548 0.0876
0.7944
 2.9694
BT-549
TNBC
Basal B
 TCS 2312
CHK1
CHK
12305.152
uM
0.58640
0.73807
 -0.3266 -0.3274 2.1895 0.3975
0.9997
 2.9694
Hs 578T
TNBC
Basal B
 Vorinostat
HDAC
HDAC
7474.065
uM
326.70210
576.8770
 -0.6003 -0.5551 1.3135 0.4292
0.9805
 2.9702
Hs 578T
TNBC
Basal B
 Trichostatin A
HDAC
HDAC
7474.065
uM
12.51970
27.53870
 -0.8230 -0.7140 1.1254 0.7081
0.9867
 2.9702
Hs 578T
TNBC
Basal B
 PS-1145
IKK
NFKB
7474.065
uM
inf
72.89010
 0.7642 0.6925 0.3457 0.0943
0.8243
 2.9702
21MT-1
HER2amp
-
 Z-Leu-Leu-Norvalinal
Proteasome
Proteasome
14191.189
uM
0.40746
0.57483
 -0.6146 -0.6271 2.3620 0.6103
0.9968
 2.9704
21MT-1
HER2amp
-
 MG-132
Proteasome
Proteasome
14191.189
uM
inf
inf
 -0.1161 -0.1161 0.0000 0.5482
0.5418
 2.9704
21MT-1
HER2amp
-
 MG-132
Proteasome
Proteasome
14191.189
uM
inf
inf
 -0.1161 -0.1161 0.0000 0.5482
0.5418
 2.9704
MCF 10A
NM
Basal B
 PD 98059
MEK
MAPK
11056.152
uM
inf
999.74860
 0.8064 -0.1009 0.5266 0.0422
0.8157
 2.9748
MCF 10A
NM
Basal B
 NSC 663284
CDC25
CDC
11056.152
uM
2.5150
3.6580
 -0.5954 -0.5991 2.1023 0.4848
0.9995
 2.9748
MCF 10A
NM
Basal B
 TCS 2312
CHK1
CHK
11056.152
uM
1.37080
1.66080
 -0.4430 -0.4364 3.2697 0.3155
0.9989
 2.9748
SUM159PT
TNBC
Basal B
 Geldanamycin
HSP90
HSP90
7918.012
uM
0.00713
0.00736
 -0.2575 -0.0364 2.2014 0.7476
0.8332
 2.9753
SUM159PT
TNBC
Basal B
 Trametinib
MEK
MAPK
7918.012
uM
0.49909
0.03458
 0.2353 0.3172 0.3770 0.3151
0.8166
 2.9753
SUM159PT
TNBC
Basal B
 CPT-11
TOP1
TOP
7918.007
uM
5.45080
8.01590
 -0.4277 -0.4612 1.6947 0.2431
0.9949
 2.9756
SUM159PT
TNBC
Basal B
 Doxorubicin
TOP2
TOP
7918.007
uM
0.10887
0.25075
 -0.6820 -0.4974 0.8278 0.6724
0.9603
 2.9756
SUM159PT
TNBC
Basal B
 Topotecan
TOP1
TOP
7918.007
uM
0.04050
0.03894
 -0.4639 0.0892 4.9965 0.5953
0.6077
 2.9756
BT-549
TNBC
Basal B
 17-AAG
HSP90
HSP90
9024.05
uM
0.02921
0.03286
 -0.1856 -0.1216 1.8477 0.7101
0.9907
 2.9873
BT-549
TNBC
Basal B
 Trametinib
MEK
MAPK
9024.05
uM
inf
0.01553
 0.6264 0.6139 0.4683 0.2073
0.9764
 2.9873
BT-549
TNBC
Basal B
 ICRF-193
TOP2
TOP
12305.157
uM
inf
0.22786
 0.6315 0.5881 0.3501 0.1796
0.8666
 2.9955