Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 5900.085 | uM | 0.22253 | 0.56950 | -0.7376 | -0.7889 | 1.0076 | 0.5715 | 0.9983 | 2.6391 | |
| MCF12A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7490.067 | uM | 7.63710 | 11.76840 | -0.7152 | -0.7251 | 2.0726 | 0.3536 | 0.9981 | 2.6472 | |
| MCF12A | NM | Basal B | Ispinesib | KSP | Kinesin | 7490.067 | uM | 0.14468 | 2.57510 | -0.6794 | -1.0000 | 0.3816 | 0.4977 | 0.8901 | 2.6472 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 7490.067 | uM | inf | inf | 0.9463 | 0.9463 | 0.0000 | 0.0115 | 0.2333 | 2.6472 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7474.071 | uM | 38.7770 | 28.5060 | 0.3928 | 0.3924 | 4.9912 | 0.0331 | 0.9633 | 2.6483 | |
| MCF 10A | NM | Basal B | Cetuximab | EGFR | ErbB | 9551.026 | uM | inf | 0.14350 | 0.7282 | 0.7281 | 4.9914 | 0.0090 | 0.9280 | 2.6508 | |
| MCF 10A | NM | Basal B | CGC-11047 | Polyamine analogue | 9551.026 | uM | 185.91980 | 1000.00000 | -0.6377 | -0.8853 | 0.6057 | 0.3813 | 0.7752 | 2.6508 | ||
| MCF 10A | NM | Basal B | Trastuzumab | HER2 | ErbB | 9551.026 | uM | inf | inf | 0.9124 | 0.9124 | 0.0000 | -0.0111 | 0.4645 | 2.6508 | |
| MCF 10A | NM | Basal B | GSK1838705A | IGF1R | RTK | 7484.09 | uM | inf | 0.39993 | 0.5550 | 0.5919 | 1.0858 | 0.1983 | 0.9279 | 2.6525 | |
| MCF 10A | NM | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7484.09 | uM | 27.63420 | 39.63650 | -0.7365 | -0.7394 | 2.5167 | 0.3858 | 0.9956 | 2.6525 | |
| MCF 10A | NM | Basal B | Erlotinib | EGFR | ErbB | 7484.09 | uM | 1.93170 | 3.34270 | -0.0487 | -0.2143 | 0.6504 | 0.3081 | 0.9911 | 2.6525 | |
| MCF 10A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7484.094 | uM | inf | 0.87271 | 0.6437 | 0.6466 | 1.6780 | 0.2352 | 0.8160 | 2.6561 | |
| MCF 10A | NM | Basal B | Ixabepilone | TUBB | TUBB | 7484.094 | uM | 0.00437 | 0.04204 | -0.7526 | -0.8693 | 0.4448 | 1.2063 | 0.9147 | 2.6561 | |
| HBL-100 | Unknown | Unknown | GSK1070916 | AURK | AURK | 9226.001 | uM | 0.70349 | 3.20790 | -0.7877 | -1.0000 | 0.7241 | 0.4535 | 0.9635 | 2.6569 | |
| HBL-100 | Unknown | Unknown | GSK461364 | PLK1 | PLK | 9226.001 | uM | 0.11473 | 5.26970 | -0.7351 | -1.0000 | 0.2871 | 0.4874 | 0.6569 | 2.6569 | |
| HBL-100 | Unknown | Unknown | GSK923295 | CENPE | Kinesin | 9226.001 | uM | 0.04394 | 0.03581 | 0.1416 | 0.2409 | 3.2103 | 0.4106 | 0.9796 | 2.6569 | |
| Hs 578T | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 7474.084 | uM | 0.83282 | 1.00080 | -0.8699 | -0.7532 | 5.0000 | 0.4995 | 0.9908 | 2.6631 | |
| Hs 578T | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7474.084 | uM | 474.21380 | 590.74280 | -0.8699 | -1.0000 | 5.0000 | 0.1198 | 0.9846 | 2.6631 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 7474.084 | uM | inf | inf | 0.8512 | 0.8512 | 0.0000 | 0.0976 | 0.4506 | 2.6631 | |
| MCF 10A | NM | Basal B | Sirolimus | MTOR | MTOR | 7484.068 | uM | 8.15170 | 9.87540 | 0.1105 | -0.0202 | 0.2065 | 0.3579 | 0.6480 | 2.6661 | |
| MCF 10A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7483.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 2.6732 | |
| MCF 10A | NM | Basal B | Ixabepilone | TUBB | TUBB | 7483.095 | uM | 0.0160 | 0.11519 | -0.8965 | -0.9405 | 0.5360 | 0.8532 | 0.9476 | 2.6732 | |
| Hs 578T | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7473.067 | uM | 7.10170 | 8.68080 | -0.8838 | -0.8632 | 4.9954 | 0.4373 | 0.9845 | 2.6736 | |
| Hs 578T | TNBC | Basal B | Ispinesib | KSP | Kinesin | 7473.067 | uM | 0.93986 | 5.19730 | -0.8838 | -1.0000 | 0.6424 | 0.3695 | 0.8768 | 2.6736 | |
| Hs 578T | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7473.067 | uM | inf | inf | 0.9516 | 0.9516 | 0.0000 | -0.0284 | -0.2407 | 2.6736 |