Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10816.148 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.7402 | |
| CAMA-1 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7805.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0217 | -0.4906 | 1.1451 | |
| MDA-MB-157 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7495.069 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0388 | 0.0179 | 0.5089 | |
| HCC1937 | TNBC | Basal A | Nilotinib | ABL | nRTK | 11849.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0324 | 0.0000 | 1.5253 | |
| MDA-MB-415 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7510.094 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0419 | -8.1247 | 0.8152 | |
| HCC2185 | TNBC | Luminal | Nilotinib | ABL | nRTK | 12192.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0217 | -0.1880 | 0.4175 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 10874.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0057 | -0.0198 | 0.8505 | |
| MCF 10A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7483.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 2.6732 | |
| MDA-MB-134-VI | HR+ | Luminal | Epirubicin | TOP2 | TOP | 7877.017 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.1618 | 0.3038 | 0.6955 | |
| MDA-MB-361 | HER2amp | Luminal | Sulindac sulfide | COX1/2 | COX | 10643.136 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0432 | -6.6439 | 0.5141 | |
| HCC70 | TNBC | Basal A | Nilotinib | ABL | nRTK | 10873.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0001 | -0.0012 | 1.2454 | |
| MDA-MB-415 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9664.049 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.7193 | |
| LY2 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 10816.149 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0238 | -0.1642 | 0.4545 | |
| MDA-MB-361 | HER2amp | Luminal | SB-3CT | MMP2/9 | MMP | 12379.168 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.4672 | |
| HCC1806 | TNBC | Basal A | Erlotinib | EGFR | ErbB | 7450.091 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0008 | 0.1356 | 1.0419 | |
| MCF 10A | NM | Basal B | Nilotinib | ABL | nRTK | 11056.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0366 | -2.6666 | 2.8383 | |
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 7898.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0820 | 0.0614 | 0.7130 | |
| BT-20 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5902.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.0245 | |
| BT-20 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 10385.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0010 | 0.0617 | 0.7986 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7528.071 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.5828 | |
| SUM159PT | TNBC | Basal B | PS-1145 | IKK | NFKB | 7531.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0370 | -7.5867 | 3.4461 | |
| SUM159PT | TNBC | Basal B | Ro 32-0432 | PKC | PKC | 10520.142 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0236 | -0.3274 | 3.1766 | |
| MDA-MB-231 | TNBC | Basal B | PS-1145 | IKK | NFKB | 7504.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0441 | -20.3886 | 1.6220 | |
| MDA-MB-361 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 10999.144 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.1189 | 0.2272 | 0.6880 | |
| HCC38 | TNBC | Basal B | Nilotinib | ABL | nRTK | 11850.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0017 | -0.0001 | 2.1492 |