Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | Nilotinib | ABL | nRTK | 12224.145 | uM | inf | inf | 0.9894 | 0.9894 | 0.0000 | -0.0249 | -0.6099 | 0.9737 | |
| 600MPE | HR+ | Luminal | PS-1145 | IKK | NFKB | 5898.065 | uM | inf | inf | 0.9898 | 0.9898 | 0.0000 | 0.1430 | 0.0000 | 0.6845 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 7435.084 | uM | inf | inf | 0.9904 | 0.9904 | 0.0000 | 0.0540 | 0.2974 | 0.8646 | |
| UACC-812 | HER2amp | Luminal | Nelfinavir | 13078.174 | uM | inf | inf | 0.9914 | 0.9914 | 0.0000 | 0.0487 | 0.0000 | 0.6238 | |||
| HBL-100 | Unknown | Unknown | AG1024 | IGF1R | RTK | 7429.066 | uM | inf | inf | 0.9919 | 0.9919 | 0.0000 | 0.0080 | 0.0137 | 2.3904 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 7515.092 | uM | inf | inf | 0.9927 | 0.9927 | 0.0000 | 0.1054 | 0.0039 | 1.2024 | |
| HCC38 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7469.098 | uM | inf | inf | 0.9936 | 0.9936 | 0.0000 | 0.0222 | 0.1591 | 2.0111 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 10261.026 | uM | inf | inf | 0.9943 | 0.9943 | 0.0000 | -0.0202 | -1.1867 | 2.4866 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 7808.052 | uM | inf | inf | 0.9944 | 0.9944 | 0.0000 | -0.0231 | -0.8225 | 2.4842 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 5902.084 | uM | inf | inf | 0.9945 | 0.9945 | 0.0000 | -0.0077 | -0.0317 | 1.3532 | |
| Hs 578T | TNBC | Basal B | Dichloroacetate | PDK | PDK | 12622.176 | uM | inf | inf | 0.9947 | 0.9947 | 0.0000 | -0.0101 | -0.9347 | 2.5005 | |
| MDA-MB-157 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7879.018 | uM | inf | inf | 0.9952 | 0.9952 | 0.0000 | -0.0245 | -1.0109 | 1.7910 | |
| MDA-MB-453 | TNBC | Luminal | Cetuximab | EGFR | ErbB | 7903.042 | uM | inf | inf | 0.9956 | 0.9956 | 0.0000 | -0.0024 | -0.0113 | 1.1508 | |
| HCC1187 | TNBC | Basal A | Ro 32-0432 | PKC | PKC | 10518.142 | uM | inf | inf | 0.9965 | 0.9965 | 0.0000 | 0.0075 | 0.0002 | 1.2869 | |
| MCF7 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9583.026 | uM | inf | inf | 0.9966 | 0.9966 | 0.0000 | 0.0156 | -0.0344 | 1.2731 | |
| SK-BR-3 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 11851.154 | uM | inf | inf | 0.9971 | 0.9971 | 0.0000 | 0.0156 | 0.0000 | 1.1765 | |
| 184A1 | NM | Basal | FTase Inhibitor I | Ftase | MAPK | 12509.167 | uM | inf | inf | 0.9988 | 0.9988 | 0.0000 | -0.0033 | -0.0009 | 1.4256 | |
| HCC38 | TNBC | Basal B | GW843682X | PLK | PLK | 10578.139 | uM | inf | inf | 0.9988 | 0.9988 | 0.0000 | -0.0137 | -0.1933 | 1.6434 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 5902.066 | uM | inf | inf | 0.9990 | 0.9990 | 0.0000 | -0.0235 | -0.9254 | 1.1775 | |
| HCC1937 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 7453.088 | uM | inf | inf | 0.9998 | 0.9998 | 0.0000 | -0.0300 | -1.8689 | 1.5634 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 7458.091 | uM | inf | inf | 1.0005 | 1.0005 | 0.0000 | 0.1959 | 0.0969 | 0.5499 | |
| HCC1395 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7816.042 | uM | inf | inf | 1.0005 | 1.0005 | 0.0000 | -0.0101 | -0.0006 | 0.9332 | |
| Hs 578T | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7475.095 | uM | inf | inf | 1.0008 | 1.0008 | 0.0000 | -0.0341 | -3.2051 | 2.2334 | |
| HCC1937 | TNBC | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7453.084 | uM | inf | inf | 1.0008 | 1.0008 | 0.0000 | -0.0055 | -0.0025 | 1.5592 | |
| HCC70 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 7470.088 | uM | inf | inf | 1.0012 | 1.0012 | 0.0000 | -0.0041 | -0.0107 | 1.1071 |