Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7531.098 | uM | inf | inf | 0.9783 | 0.9783 | 0.0000 | -0.0040 | 0.0169 | 3.4793 | |
| HCC1954 | HER2amp | Basal A | Nilotinib | ABL | nRTK | 11055.145 | uM | inf | inf | 0.9791 | 0.9791 | 0.0000 | -0.0257 | -0.8188 | 1.7616 | |
| MDA-MB-415 | HR+ | Luminal | AG1024 | IGF1R | RTK | 7511.066 | uM | inf | inf | 0.9792 | 0.9792 | 0.0000 | -0.0212 | -0.3797 | 1.1691 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 5900.067 | uM | inf | inf | 0.9793 | 0.9793 | 0.0000 | -0.0189 | -0.4227 | 2.4324 | |
| MDA-MB-361 | HER2amp | Luminal | GM6001 | MMP | MMP | 7506.096 | uM | inf | inf | 0.9793 | 0.9793 | 0.0000 | 0.0173 | -0.0292 | 1.0303 | |
| MDA-MB-134-VI | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7494.098 | uM | inf | inf | 0.9802 | 0.9802 | 0.0000 | 0.0609 | -0.0984 | 0.9748 | |
| AU565 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 10880.145 | uM | inf | inf | 0.9804 | 0.9804 | 0.0000 | 0.0621 | 0.0247 | 1.4751 | |
| AU565 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 5901.065 | uM | inf | inf | 0.9807 | 0.9807 | 0.0000 | 0.0027 | -0.0002 | 2.0114 | |
| HCC1419 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 10019.124 | uM | inf | inf | 0.9810 | 0.9810 | 0.0000 | -0.0457 | -3.7312 | 0.5356 | |
| HCC1187 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7811.044 | uM | inf | inf | 0.9811 | 0.9811 | 0.0000 | 0.0159 | -0.0256 | 0.3073 | |
| HCC1954 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 11055.154 | uM | inf | inf | 0.9813 | 0.9813 | 0.0000 | 0.0080 | -0.0117 | 1.7768 | |
| MB 157 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 12580.165 | uM | inf | inf | 0.9815 | 0.9815 | 0.0000 | 0.0012 | 0.1111 | 2.2883 | |
| T47DKBLUC | Unknown | Unknown | FTase Inhibitor I | Ftase | MAPK | 12608.167 | uM | inf | inf | 0.9819 | 0.9819 | 0.0000 | -0.0030 | 0.1862 | 1.2681 | |
| MCF 10A | NM | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7484.098 | uM | inf | inf | 0.9819 | 0.9819 | 0.0000 | 0.0183 | 0.3261 | 2.6137 | |
| HCC70 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 7860.043 | uM | inf | inf | 0.9822 | 0.9822 | 0.0000 | 0.0201 | 0.2254 | 0.7488 | |
| BT-549 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 5910.091 | uM | inf | inf | 0.9825 | 0.9825 | 0.0000 | 0.0118 | 0.2290 | 3.3208 | |
| HCC1806 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 12239.154 | uM | inf | inf | 0.9833 | 0.9833 | 0.0000 | 0.0201 | 0.0190 | 2.2015 | |
| MDA-MB-231 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7892.016 | uM | inf | inf | 0.9839 | 0.9839 | 0.0000 | -0.0090 | -0.1042 | 2.3475 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 10473.137 | uM | inf | inf | 0.9840 | 0.9840 | 0.0000 | 0.0297 | -0.0565 | 1.1322 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 5902.098 | uM | inf | inf | 0.9860 | 0.9860 | 0.0000 | -0.0045 | -0.0403 | 1.1137 | |
| MCF7 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 10997.144 | uM | inf | inf | 0.9861 | 0.9861 | 0.0000 | 0.0703 | 0.2540 | 1.2750 | |
| SUM149PT | TNBC | Basal B | Nilotinib | ABL | nRTK | 10819.145 | uM | inf | inf | 0.9866 | 0.9866 | 0.0000 | 0.0162 | 0.0826 | 2.1971 | |
| MDA-MB-361 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9648.026 | uM | inf | inf | 0.9880 | 0.9880 | 0.0000 | -0.0302 | -1.2808 | 0.7065 | |
| MDA-MB-157 | TNBC | Basal B | AG1024 | IGF1R | RTK | 7498.066 | uM | inf | inf | 0.9884 | 0.9884 | 0.0000 | -0.0181 | -0.3947 | 1.0752 | |
| BT-474 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 5906.067 | uM | inf | inf | 0.9890 | 0.9890 | 0.0000 | -0.0331 | -0.7588 | 0.6838 |