Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM185PE | TNBC | Luminal | AS-252424 | PI3K | PI3K | 12269.165 | uM | 3.54270 | 4.22680 | -0.7071 | -0.7088 | 5.0000 | 0.2824 | 0.9926 | 0.6001 | |
| HCC1187 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7432.067 | uM | 5.81250 | 7.2390 | -0.9992 | -0.9981 | 5.0000 | 0.4502 | 0.9970 | 1.0373 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 9708.012 | uM | 0.19657 | 0.08096 | 0.4504 | 0.4941 | 5.0000 | 0.2016 | 0.9603 | 0.9799 | |
| HCC1187 | TNBC | Basal A | Taxol | TUBB | TUBB | 12696.002 | uM | 0.00802 | 0.00995 | -0.9713 | -0.9731 | 5.0000 | 1.2723 | 0.9944 | 0.7184 | |
| HCC1187 | TNBC | Basal A | Taxol | TUBB | TUBB | 9244.002 | uM | 0.00722 | 0.00898 | -0.9968 | -0.9950 | 5.0000 | 1.2989 | 0.9984 | 0.5206 | |
| HCC1187 | TNBC | Basal A | Taxol | TUBB | TUBB | 7812.002 | uM | 0.00801 | 0.00970 | -0.8107 | -0.8039 | 5.0000 | 1.1382 | 0.9988 | 1.0730 | |
| MCF 10F | NM | - | Methotrexate | DHFR | Metabolism | 7487.084 | uM | 0.09336 | 0.07754 | 0.2750 | 0.3024 | 5.0000 | 0.4595 | 0.9971 | 1.3396 | |
| HBL-100 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 7429.084 | uM | inf | 0.12857 | 0.6858 | 0.7716 | 5.0000 | 0.1377 | 0.8694 | 2.2510 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 10518.14 | uM | 1.0160 | 1.24260 | -0.8690 | -0.8683 | 5.0000 | 0.4833 | 0.9979 | 1.2052 | |
| MDA-MB-175-VII | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14269.189 | uM | 0.16097 | 0.19121 | -0.9893 | -0.6827 | 5.0000 | 0.8112 | 0.8780 | 0.5173 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 7510.067 | uM | 170.140 | 174.92770 | 0.5243 | -0.0744 | 5.0000 | 0.0185 | 0.8706 | 0.8348 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 7518.071 | uM | 7.2660 | 8.48420 | -0.6065 | -0.5853 | 5.0000 | 0.2913 | 0.9973 | 1.4797 | |
| HCC1806 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7451.091 | uM | 6.78910 | 7.13420 | -0.7375 | -0.1407 | 5.0000 | 0.3243 | 0.6889 | 2.1415 | |
| HCC1187 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 7433.065 | uM | 4.75510 | 5.90980 | -0.9877 | -0.9827 | 5.0000 | 1.0545 | 0.9988 | 0.8820 | |
| HCC1187 | TNBC | Basal A | Triciribine | AKT | AKT | 7431.074 | uM | 0.30781 | 0.32441 | -0.1484 | -0.1501 | 5.0000 | 0.4317 | 0.9260 | 1.4349 | |
| MCF 10F | NM | - | ZM-447439 | AURK | AURK | 12254.16 | uM | inf | 2.36150 | 0.5734 | 0.7090 | 5.0000 | 0.0457 | 0.7984 | 1.4029 | |
| HCC1187 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7811.018 | uM | 0.01088 | 0.01347 | -0.9977 | -0.9563 | 5.0000 | 1.2447 | 0.9982 | 0.4694 | |
| HCC1187 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 7432.065 | uM | 19.95780 | 24.69860 | -0.9931 | -0.9513 | 5.0000 | 1.0060 | 0.9964 | 0.7981 | |
| SUM185PE | TNBC | Luminal | Docetaxel | TUBB | TUBB | 10146.002 | uM | inf | 0.01745 | 0.6289 | 0.5622 | 5.0000 | 0.2445 | 0.6138 | 0.9649 | |
| SUM185PE | TNBC | Luminal | Docetaxel | TUBB | TUBB | 7921.002 | uM | 0.01572 | 0.01584 | 0.0138 | -0.0205 | 5.0000 | 0.5296 | 0.9755 | 0.7161 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 10380.092 | uM | 0.46366 | 0.42214 | 0.1747 | 0.1872 | 5.0000 | 0.3130 | 0.9930 | 1.4888 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 7477.066 | uM | 5.95670 | 7.42050 | -1.0000 | -1.0000 | 5.0000 | 0.4047 | 0.9709 | 0.3409 | |
| HCC1187 | TNBC | Basal A | XRP44X | ELK3 | MAPK | 10518.139 | uM | 1.20340 | 1.41520 | -0.7378 | -0.6246 | 5.0000 | 0.5809 | 0.9830 | 1.2366 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10518.138 | uM | 0.23611 | 0.23002 | 0.0120 | 0.0612 | 5.0000 | 0.4780 | 0.9213 | 1.3413 | |
| BT-474 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5905.067 | uM | 10.87560 | 13.54810 | -0.9993 | -1.0000 | 5.0000 | 0.3691 | 0.9961 | 0.7991 |