Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAL-85-1 | TNBC | - | Bortezomib | Proteasome | Proteasome | 15280.203 | uM | 0.00265 | 0.00507 | -0.9828 | -0.9851 | 1.6797 | 1.4734 | 0.9952 | 0.7211 | |
| CAL-85-1 | TNBC | - | Bortezomib | Proteasome | Proteasome | 15280.203 | uM | 0.00265 | 0.00507 | -0.9828 | -0.9851 | 1.6797 | 1.4734 | 0.9952 | 0.7211 | |
| SUM1315MO2 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 14799.203 | uM | 0.00211 | 0.00437 | -0.9908 | -0.9739 | 1.4879 | 1.4750 | 0.9993 | 0.9401 | |
| SUM1315MO2 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 14799.203 | uM | 0.00211 | 0.00437 | -0.9908 | -0.9739 | 1.4879 | 1.4750 | 0.9993 | 0.9401 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 9469.121 | uM | 0.00096 | 0.00177 | -0.7010 | -0.7334 | 1.4902 | 1.4796 | 0.9951 | 1.1298 | |
| HCC202 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 10470.087 | uM | 0.00098 | 0.00256 | -0.9996 | -1.0000 | 1.1390 | 1.4830 | 0.9905 | 0.3641 | |
| HCC38 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9469.131 | uM | inf | inf | -0.7980 | -0.7980 | 0.0000 | 1.5023 | 0.0000 | 1.0627 | |
| ZR-75-1 | HR+ | Luminal | Torkinib | 15346.211 | uM | 0.00002 | 0.00009 | -0.6847 | -0.6526 | 0.5569 | 1.5120 | 0.9820 | 0.6395 | |||
| HCC1395 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7813.018 | uM | 0.00024 | 0.00082 | -0.9987 | -0.8558 | 0.8040 | 1.5321 | 0.9392 | 0.8420 | |
| HCC1187 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 7432.095 | uM | 0.00090 | 0.00136 | -0.9922 | -0.9565 | 2.5808 | 1.5603 | 0.9988 | 0.8368 | |
| HCC1954 | HER2amp | Basal A | Ixabepilone | TUBB | TUBB | 7457.094 | uM | 0.00051 | 0.00078 | -0.8956 | -0.6816 | 2.0313 | 1.5901 | 0.9463 | 1.8462 | |
| MDA-MB-453 | TNBC | Luminal | Vinorelbine | TUBB | TUBB | 9708.006 | uM | inf | inf | -1.0000 | -1.0000 | 0.0000 | 1.6076 | 0.3995 | 0.6313 | |
| HCC38 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 10268.12 | uM | 0.00161 | 0.00201 | -0.9994 | -1.0000 | 5.0000 | 1.6132 | 0.9985 | 0.3272 | |
| MDA-MB-468 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7906.018 | uM | 0.00003 | 0.00009 | -0.9241 | -0.7076 | 0.8524 | 1.6148 | 0.7919 | 0.9087 | |
| HCC1187 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 15300.203 | uM | 0.00104 | 0.00168 | -0.9901 | -0.9929 | 2.2895 | 1.6434 | 0.9968 | 0.8443 | |
| HCC1187 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 15300.203 | uM | 0.00104 | 0.00168 | -0.9901 | -0.9929 | 2.2895 | 1.6434 | 0.9968 | 0.8443 | |
| SUM1315MO2 | TNBC | Basal B | Torkinib | 15401.211 | uM | -inf | 0.00012 | -0.9603 | -0.8964 | 0.4331 | 1.6631 | 0.9588 | 0.4079 | |||
| HCC70 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 14739.203 | uM | 0.00093 | 0.00145 | -0.9973 | -0.9997 | 2.4844 | 1.6705 | 0.9952 | 0.6862 | |
| HCC70 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 14739.203 | uM | 0.00093 | 0.00145 | -0.9973 | -0.9997 | 2.4844 | 1.6705 | 0.9952 | 0.6862 | |
| SUM1315MO2 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9797.006 | uM | 0.00425 | 0.00528 | -1.0000 | -0.9693 | 4.9995 | 1.7533 | 0.9968 | 0.4196 | |
| UACC-812 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 10267.131 | uM | inf | inf | -0.8066 | -0.8066 | 0.0000 | 1.7801 | 0.1971 | 0.3849 | |
| HCC38 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9028.075 | uM | 0.00457 | 0.00564 | -0.9576 | -0.9350 | 5.0000 | 1.7932 | 0.9991 | 0.6011 | |
| HCC70 | TNBC | Basal A | Torkinib | 15390.211 | uM | -inf | 0.00003 | -0.9960 | -0.9803 | 0.5245 | 1.8586 | 0.9905 | 0.5021 |