Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 7865.018 | uM | inf | inf | -0.9931 | -0.9931 | 0.0000 | 1.0189 | 0.3416 | 1.1920 | ||
| HCC1954 | HER2amp | Basal A | PS-1145 | IKK | NFKB | 7457.065 | uM | inf | inf | 0.8494 | 0.8494 | 0.0000 | 0.0471 | 0.0632 | 1.5870 | |
| HCC1395 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7813.011 | uM | inf | 2.35980 | 0.6153 | 0.5805 | 4.9965 | 0.1441 | 0.7307 | 0.8718 | |
| 184A1 | NM | Basal | Vinorelbine | TUBB | TUBB | 7787.018 | uM | inf | inf | -0.9963 | -0.9963 | 0.0000 | 0.4831 | 0.4499 | 0.3791 | |
| HCC38 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7469.09 | uM | inf | 79.23380 | 0.8694 | 0.5898 | 4.4214 | -0.0137 | 0.6395 | 1.9867 | |
| BT-20 | TNBC | Basal A | PS-1145 | IKK | NFKB | 5904.065 | uM | inf | inf | 0.7615 | 0.7615 | 0.0000 | 0.0871 | 0.5385 | 1.1681 | |
| BT-474 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 13125.176 | uM | inf | inf | 0.8740 | 0.8740 | 0.0000 | 0.0169 | 0.4953 | 0.8351 | |
| MCF 10A | NM | Basal B | Cetuximab | EGFR | ErbB | 7868.018 | uM | inf | inf | 0.9199 | 0.9199 | 0.0000 | -0.0068 | 0.4328 | 2.1110 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14191.189 | uM | inf | inf | -0.1161 | -0.1161 | 0.0000 | 0.5482 | 0.5418 | 2.9704 | |
| HCC38 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10268.12 | uM | inf | inf | -1.0000 | -1.0000 | 0.0000 | 1.2668 | 0.5308 | 0.3272 | |
| SUM229PE | TNBC | - | AG1478 | EGFR | ErbB | 9860.019 | uM | inf | 0.66920 | 0.6943 | 0.6826 | 1.3958 | 0.1614 | 0.7691 | 1.6927 | |
| HCC1395 | TNBC | Basal B | GM6001 | MMP | MMP | 7436.096 | uM | inf | inf | 0.8287 | 0.8287 | 0.0000 | 0.0732 | -0.0129 | 1.3979 | |
| SUM229PE | TNBC | - | AS-252424 | PI3K | PI3K | 11058.158 | uM | inf | 1.27320 | 0.4597 | 0.6173 | 1.6385 | 0.1628 | 0.6573 | 2.1018 | |
| SUM229PE | TNBC | - | Baicalein | Lipoxygenase | Metabolism | 11058.072 | uM | inf | 999.9990 | 0.7363 | 0.5109 | 0.1359 | 0.1245 | 0.6645 | 2.3023 | |
| HCC38 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14212.189 | uM | inf | inf | 0.4852 | 0.4852 | 0.0000 | 0.5240 | 0.4451 | 1.6254 | |
| BT-483 | HR+ | Luminal | AG1024 | IGF1R | RTK | 5908.066 | uM | inf | inf | 0.0534 | 0.0534 | 0.0000 | 0.3542 | 0.4565 | 0.4546 | |
| MDA-MB-134-VI | HR+ | Luminal | AS-252424 | PI3K | PI3K | 12206.158 | uM | inf | 3.00130 | 0.4194 | 0.6082 | 5.0000 | 0.1235 | 0.6592 | 1.1431 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 10261.131 | uM | -inf | 0.00002 | -0.3245 | -0.3912 | 0.1000 | 1.0766 | 0.7849 | 2.3992 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 10266.131 | uM | -inf | 0.00975 | -0.9900 | -1.0000 | 0.1117 | 1.3424 | 0.6662 | 0.8552 | |
| MDA-MB-415 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 12333.168 | uM | -inf | 0.00841 | -0.9982 | -1.0000 | 0.1818 | 1.2503 | 0.7864 | 0.5815 | |
| SUM1315MO2 | TNBC | Basal B | Torkinib | 15401.211 | uM | -inf | 0.00012 | -0.9603 | -0.8964 | 0.4331 | 1.6631 | 0.9588 | 0.4079 | |||
| HCC70 | TNBC | Basal A | Torkinib | 15390.211 | uM | -inf | 0.00003 | -0.9960 | -0.9803 | 0.5245 | 1.8586 | 0.9905 | 0.5021 | |||
| BT-474 | HER2amp | Luminal | Temsirolimus | MTOR | MTOR | 12291.168 | uM | -inf | 0.00735 | -0.9999 | -1.0000 | 0.2001 | 1.2788 | 0.8809 | 0.4466 |