Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Antibody	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
BT-20	TNBC	Basal A	Sulindac sulfide		COX1/2	COX	10581.136	uM	inf	inf	0.3918	0.3918	0.0000	0.1575	0.4199	0.8342
HCC1143	TNBC	Basal A	JNK-IN-5A		JNK	JNK	12112.144	uM	inf	inf	0.3013	0.3013	0.0000	0.1254	0.4665	1.9163
MDA-MB-361	HER2amp	Luminal	Baicalein		Lipoxygenase	Metabolism	10472.072	uM	inf	43.4090	0.6069	0.6059	4.4140	0.0339	0.9076	0.6135
MDA-MB-231	TNBC	Basal B	Triciribine		AKT	AKT	7504.074	uM	inf	6.09780	0.5573	0.5504	2.4534	0.0410	0.9267	1.8962
21MT-1	HER2amp	-	Dichloroacetate		PDK	PDK	13719.176	uM	inf	inf	0.9233	0.9233	0.0000	0.0596	-0.2426	0.8672
SUM225CWN	HER2amp	Basal A	PD184352		MEK	MAPK	12098.155	uM	inf	inf	0.7400	0.7400	0.0000	0.1295	0.3373	1.0503
SUM225CWN	HER2amp	Basal A	PD184352		MEK	MAPK	12098.155	uM	inf	inf	0.7400	0.7400	0.0000	0.1295	0.3373	1.0503
SUM225CWN	HER2amp	Basal A	Pemetrexed		TYMS/DHFR/GARFT	TYMS	7533.095	uM	inf	inf	0.7658	0.7658	0.0000	0.0600	0.0756	0.9850
SUM225CWN	HER2amp	Basal A	Pemetrexed		TYMS/DHFR/GARFT	TYMS	7534.095	uM	inf	inf	0.8515	0.8515	0.0000	0.0060	0.2793	0.8052
SUM225CWN	HER2amp	Basal A	PS-1145		IKK	NFKB	7534.065	uM	inf	inf	0.8726	0.8726	0.0000	-0.0301	0.3917	0.9529
SUM225CWN	HER2amp	Basal A	PS-1145		IKK	NFKB	7533.065	uM	inf	inf	0.6455	0.6455	0.0000	0.0965	0.4664	1.0679
HCC1395	TNBC	Basal B	Dactolisib		PI3K	PI3K	12000.155	uM	inf	inf	0.6675	0.6675	0.0000	0.2919	0.2735	0.8592
HCC1395	TNBC	Basal B	Dactolisib		PI3K	PI3K	12084.155	uM	inf	inf	0.8548	0.8548	0.0000	0.1129	0.4499	1.2955
SUM225CWN	HER2amp	Basal A	Ribavirin				15403.211	uM	inf	inf	0.4799	0.4799	0.0000	0.2473	0.3950	0.7553
SUM225CWN	HER2amp	Basal A	Ro 32-0432		PKC	PKC	10579.142	uM	inf	inf	1.0500	1.0500	0.0000	-0.0168	-0.2942	1.0435
SUM225CWN	HER2amp	Basal A	SB-3CT		MMP2/9	MMP	10579.144	uM	inf	inf	0.8597	0.8597	0.0000	-0.0118	0.3052	0.9576
SUM225CWN	HER2amp	Basal A	SB-3CT		MMP2/9	MMP	12098.144	uM	inf	19.97250	0.7121	0.7120	5.0000	0.0215	0.8105	1.1959
SUM225CWN	HER2amp	Basal A	Selumetinib		MEK	MAPK	12098.155	uM	inf	0.00788	0.8639	0.8687	4.9796	0.0832	0.6381	1.0503
HCC1954	HER2amp	Basal A	Purvalanol A		CDK1	CDK	7456.067	uM	inf	inf	0.6461	0.6461	0.0000	0.0807	0.4257	1.8797
HCC1395	TNBC	Basal B	Dichloroacetate		PDK	PDK	13538.176	uM	inf	inf	0.8042	0.8042	0.0000	0.1436	0.3146	0.4572
HCC1395	TNBC	Basal B	Disulfiram		Proteasome	Proteasome	13538.174	uM	inf	0.14414	0.6866	0.6441	5.0000	0.1678	0.7406	0.4615
MDA-MB-175-VII	HR+	Luminal	(Z)-4-Hydroxytamoxifen		ESR1		7885.016	uM	inf	inf	0.7529	0.7529	0.0000	0.1378	0.2398	0.7137
MCF7	HR+	Luminal		Cetuximab	EGFR	ErbB	9583.026	uM	inf	inf	0.9966	0.9966	0.0000	0.0156	-0.0344	1.2731
HCC1395	TNBC	Basal B	Doxorubicin		TOP2	TOP	7816.007	uM	inf	inf	0.3187	0.3187	0.0000	0.2775	0.3760	1.1536
SUM225CWN	HER2amp	Basal A	Sulindac sulfide		COX1/2	COX	10579.136	uM	inf	inf	1.0500	1.0500	0.0000	-0.0370	-2.7510	0.6876

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)