Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 12291.152 | uM | inf | inf | 0.2961 | 0.2961 | 0.0000 | 0.2590 | 0.4519 | 0.6792 | |
| HCC1806 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 14155.189 | uM | inf | inf | -0.8537 | -0.8537 | 0.0000 | 0.5966 | 0.5536 | 1.7812 | |
| SUM185PE | TNBC | Luminal | AG1478 | EGFR | ErbB | 7921.016 | uM | inf | inf | 0.7575 | 0.7575 | 0.0000 | 0.0452 | 0.5568 | 0.6622 | |
| MDA-MB-134-VI | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7877.042 | uM | inf | inf | 0.9001 | 0.9001 | 0.0000 | 0.0283 | 0.1356 | 0.3414 | |
| SUM185PE | TNBC | Luminal | Baicalein | Lipoxygenase | Metabolism | 12269.072 | uM | inf | inf | 0.6534 | 0.6534 | 0.0000 | 0.5211 | 0.0434 | 1.1256 | |
| MCF 10F | NM | - | Baicalein | Lipoxygenase | Metabolism | 12254.072 | uM | inf | inf | 0.9615 | 0.9615 | 0.0000 | 0.0021 | 0.0460 | 1.9429 | |
| HCC70 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7856.018 | uM | inf | inf | 0.8811 | 0.8811 | 0.0000 | 0.0121 | 0.4683 | 0.9388 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 7452.084 | uM | inf | inf | 0.9680 | 0.9680 | 0.0000 | -0.0014 | 0.1350 | 1.6800 | |
| HCC1187 | TNBC | Basal A | PD184352 | MEK | MAPK | 7812.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0727 | 0.0526 | 0.9642 | |
| SUM185PE | TNBC | Luminal | Bosutinib | Src | nRTK | 12269.145 | uM | inf | inf | 0.4269 | 0.4269 | 0.0000 | 0.1685 | 0.4528 | 0.4894 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7495.067 | uM | inf | 2.93990 | 0.4899 | 0.5744 | 4.9993 | 0.1292 | 0.8928 | 1.1275 | |
| HCC38 | TNBC | Basal B | SB-3CT | MMP2/9 | MMP | 10578.144 | uM | inf | inf | 0.7826 | 0.7826 | 0.0000 | 0.0668 | 0.4813 | 1.6376 | |
| SUM185PE | TNBC | Luminal | Cetuximab | EGFR | ErbB | 7921.042 | uM | inf | inf | 1.0399 | 1.0399 | 0.0000 | -0.0494 | -236.5755 | 0.6355 | |
| SUM185PE | TNBC | Luminal | Cetuximab | EGFR | ErbB | 10146.124 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.9296 | |
| HCC1187 | TNBC | Basal A | PD184352 | MEK | MAPK | 7812.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0727 | 0.0526 | 0.9642 | |
| SUM185PE | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10146.049 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0490 | -376.2593 | 0.8861 | |
| HCC1187 | TNBC | Basal A | PD184352 | MEK | MAPK | 10753.146 | uM | inf | inf | 0.7681 | 0.7681 | 0.0000 | 0.1159 | 0.2362 | 1.4503 | |
| BT-474 | HER2amp | Luminal | PD184352 | MEK | MAPK | 12291.155 | uM | inf | inf | 0.8808 | 0.8808 | 0.0000 | -0.0271 | -0.2848 | 0.4532 | |
| SUM185PE | TNBC | Luminal | Dactolisib | PI3K | PI3K | 12269.155 | uM | inf | inf | 0.3852 | 0.3852 | 0.0000 | 0.2665 | 0.3295 | 0.7969 | |
| SUM185PE | TNBC | Luminal | Dichloroacetate | PDK | PDK | 13140.176 | uM | inf | inf | 0.8118 | 0.8118 | 0.0000 | 0.0909 | -0.1414 | 0.6663 | |
| HCC1187 | TNBC | Basal A | PD184352 | MEK | MAPK | 10753.146 | uM | inf | inf | 0.7681 | 0.7681 | 0.0000 | 0.1159 | 0.2362 | 1.4503 | |
| SUM185PE | TNBC | Luminal | Docetaxel | TUBB | TUBB | 10146.002 | uM | inf | 0.01745 | 0.6289 | 0.5622 | 5.0000 | 0.2445 | 0.6138 | 0.9649 | |
| HCC1187 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7433.095 | uM | inf | inf | 0.2099 | 0.2099 | 0.0000 | 0.6689 | 0.1148 | 0.9260 | |
| BT-474 | HER2amp | Luminal | PD184352 | MEK | MAPK | 12291.155 | uM | inf | inf | 0.8808 | 0.8808 | 0.0000 | -0.0271 | -0.2848 | 0.4532 | |
| HCC1187 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7432.095 | uM | inf | inf | 1.0222 | 1.0222 | 0.0000 | 0.0161 | 0.1254 | 0.8368 |