Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 7886.042 | uM | 0.00036 | 0.14006 | -0.9919 | -1.0000 | 0.1845 | 0.9309 | 0.7305 | 0.6462 | |
| T47D | HR+ | Luminal | Torkinib | 15340.211 | uM | 0.00038 | 0.00069 | -0.2049 | -0.1299 | 0.3943 | 0.8877 | 0.9641 | 1.5685 | |||
| MDA-MB-415 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7512.095 | uM | 0.00042 | 0.10389 | -0.9926 | -1.0000 | 0.1993 | 0.9414 | 0.6868 | 0.8452 | |
| BT-549 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7803.042 | uM | 0.00050 | 0.00052 | -0.5972 | -0.0656 | 2.5414 | 0.9089 | 0.7256 | 2.8270 | |
| HCC1428 | HR+ | Luminal | Torkinib | 15350.211 | uM | 0.00051 | 0.02111 | -0.6104 | -0.8283 | 0.2630 | 1.0478 | 0.9487 | 1.0306 | |||
| HCC1954 | HER2amp | Basal A | Ixabepilone | TUBB | TUBB | 7457.094 | uM | 0.00051 | 0.00078 | -0.8956 | -0.6816 | 2.0313 | 1.5901 | 0.9463 | 1.8462 | |
| UACC-812 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 7547.087 | uM | 0.00057 | 0.00410 | -0.5482 | -0.6130 | 0.4045 | 1.0863 | 0.9374 | 0.9847 | |
| CAL-85-1 | TNBC | - | Torkinib | 15280.211 | uM | 0.00057 | 0.00844 | -0.8064 | -0.8633 | 0.3733 | 1.1993 | 0.9944 | 0.8608 | |||
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 7906.012 | uM | 0.00062 | 0.00321 | -0.8093 | -0.7684 | 0.5677 | 1.3829 | 0.6159 | 0.4916 | |
| HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7841.001 | uM | 0.00065 | 0.00073 | -0.7519 | -0.1312 | 2.0815 | 0.9082 | 0.6730 | 0.5424 | |
| CAMA-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 5912.095 | uM | 0.00065 | 0.00095 | -0.9867 | -0.7402 | 2.3688 | 1.4206 | 0.9535 | 0.9981 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7904.001 | uM | 0.00066 | 0.00071 | -0.0087 | -0.2074 | 5.0000 | 1.0124 | 0.6937 | 1.3917 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 7839.001 | uM | 0.00067 | 0.00070 | -0.4867 | -0.1112 | 5.0000 | 0.8932 | 0.8549 | 1.8919 | |
| MDA-MB-231 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7504.095 | uM | 0.00069 | 0.11642 | -0.9613 | -1.0000 | 0.2143 | 0.9276 | 0.7141 | 2.0796 | |
| AU565 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9035.001 | uM | 0.00071 | 0.00076 | 0.2153 | -0.1767 | 5.0000 | 0.9858 | 0.7915 | 2.4291 | |
| HMT-3522 S1 | Unknown | Unknown | Trametinib | MEK | MAPK | 10124.012 | uM | 0.00074 | 0.00053 | 0.2498 | 0.2658 | 2.3479 | 0.6006 | 0.9280 | 1.9565 | |
| MDA-MB-453 | TNBC | Luminal | Torkinib | 15398.211 | uM | 0.00074 | 0.00583 | -0.5991 | -0.5679 | 0.3671 | 1.0368 | 0.9859 | 1.0628 | |||
| SUM159PT | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7918.018 | uM | 0.00074 | 0.00109 | -0.5523 | -0.3456 | 1.3735 | 1.1044 | 0.9653 | 3.0213 | |
| SUM1315MO2 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 9797.002 | uM | 0.00077 | 0.00224 | -0.9724 | -0.9777 | 1.0171 | 1.2866 | 0.9990 | 0.4052 | |
| EFM-192C | HER2amp | Luminal | Torkinib | 15292.211 | uM | 0.00077 | 0.00081 | -0.2486 | -0.0154 | 0.7454 | 0.8411 | 0.8375 | 1.7715 | |||
| SUM159PT | TNBC | Basal B | Docetaxel | TUBB | TUBB | 13054.002 | uM | 0.00080 | 0.00091 | -0.1135 | -0.1113 | 1.6186 | 0.8007 | 0.9974 | 3.0574 | |
| BT-474 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 12291.165 | uM | 0.00084 | 0.00487 | -0.9997 | -1.0000 | 0.6233 | 1.4610 | 0.9623 | 0.5602 | |
| HCC2185 | TNBC | Luminal | Sirolimus | MTOR | MTOR | 7845.068 | uM | 0.00087 | 0.00157 | -0.5451 | -0.3982 | 0.9850 | 1.2168 | 0.9289 | 0.3849 | |
| MDA-MB-361 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 7508.095 | uM | 0.00087 | 0.00130 | -0.9942 | -0.6037 | 1.9635 | 1.2595 | 0.9267 | 0.7473 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 7491.05 | uM | 0.00089 | 0.00201 | -0.8158 | -0.7549 | 1.1339 | 1.2287 | 0.9929 | 0.5814 |