Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 7533.084 | uM | inf | inf | 0.9294 | 0.9294 | 0.0000 | -0.0224 | 0.2330 | 1.0396 | |
| MB 157 | Unknown | Unknown | PS-1145 | IKK | NFKB | 7482.065 | uM | inf | inf | 0.9413 | 0.9413 | 0.0000 | 0.0141 | 0.0523 | 2.2390 | |
| HCC70 | TNBC | Basal A | PD 98059 | MEK | MAPK | 12400.152 | uM | inf | inf | 0.7537 | 0.7537 | 0.0000 | 0.0534 | -0.0064 | 1.1392 | |
| HCC3153 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7853.016 | uM | inf | inf | 0.9101 | 0.9101 | 0.0000 | 0.0481 | 0.4996 | 1.6178 | |
| CAMA-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 10755.146 | uM | inf | inf | 0.7200 | 0.7200 | 0.0000 | 0.1412 | 0.2466 | 0.8035 | |
| HCC1395 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7816.017 | uM | inf | inf | 0.6386 | 0.6386 | 0.0000 | 0.2394 | 0.3980 | 1.2318 | |
| HCC1143 | TNBC | Basal A | Chloroquine | 13099.177 | uM | inf | inf | -0.9999 | -0.9999 | 0.0000 | 0.7050 | 0.1850 | 0.7419 | |||
| SUM225CWN | HER2amp | Basal A | Nilotinib | ABL | nRTK | 10579.145 | uM | inf | inf | 0.7382 | 0.7382 | 0.0000 | 0.1219 | 0.2766 | 1.0664 | |
| SUM225CWN | HER2amp | Basal A | Nilotinib | ABL | nRTK | 12098.145 | uM | inf | inf | 0.9374 | 0.9374 | 0.0000 | 0.0259 | 0.3617 | 0.9769 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 10997.155 | uM | inf | inf | 0.9516 | 0.9516 | 0.0000 | -0.0284 | -0.8847 | 1.3159 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10938.15 | uM | inf | inf | 0.5380 | 0.5380 | 0.0000 | 0.3086 | -0.0630 | 1.0480 | |
| MDA-MB-361 | HER2amp | Luminal | NU6102 | CDK1/2 | CDK | 12379.147 | uM | inf | inf | -1.0000 | -1.0000 | 0.0000 | 0.2178 | 0.2648 | 0.3192 | |
| MDA-MB-361 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 9648.132 | uM | inf | inf | 0.2751 | 0.2751 | 0.0000 | 0.2918 | 0.2312 | 0.7147 | |
| MCF 10F | NM | - | (Z)-4-Hydroxytamoxifen | ESR1 | 7488.016 | uM | inf | inf | 0.7328 | 0.7328 | 0.0000 | 0.0898 | 0.5484 | 1.2238 | ||
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 7474.066 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0000 | -0.0022 | 2.7948 | |
| HCC38 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7854.018 | uM | inf | inf | 0.7802 | 0.7802 | 0.0000 | 0.1098 | 0.010 | 1.2298 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7507.094 | uM | inf | inf | 0.0352 | 0.0352 | 0.0000 | 0.6740 | 0.2984 | 1.0418 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 12000.167 | uM | inf | inf | 0.7814 | 0.7814 | 0.0000 | 0.1511 | -0.0746 | 0.7185 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 12084.154 | uM | inf | inf | 0.7715 | 0.7715 | 0.0000 | 0.1395 | -0.0309 | 1.2963 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 12178.16 | uM | inf | inf | 0.5577 | 0.5577 | 0.0000 | 0.3142 | 0.4077 | 0.7392 | |
| SUM225CWN | HER2amp | Basal A | PD184352 | MEK | MAPK | 12098.155 | uM | inf | inf | 0.7400 | 0.7400 | 0.0000 | 0.1295 | 0.3373 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | PD184352 | MEK | MAPK | 12098.155 | uM | inf | inf | 0.7400 | 0.7400 | 0.0000 | 0.1295 | 0.3373 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7533.095 | uM | inf | inf | 0.7658 | 0.7658 | 0.0000 | 0.0600 | 0.0756 | 0.9850 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7534.095 | uM | inf | inf | 0.8515 | 0.8515 | 0.0000 | 0.0060 | 0.2793 | 0.8052 | |
| SUM225CWN | HER2amp | Basal A | PS-1145 | IKK | NFKB | 7534.065 | uM | inf | inf | 0.8726 | 0.8726 | 0.0000 | -0.0301 | 0.3917 | 0.9529 |