Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 10379.092 | uM | inf | inf | 0.8925 | 0.8925 | 0.0000 | 0.0585 | -0.0549 | 2.5811 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 5905.085 | uM | inf | inf | 0.8672 | 0.8672 | 0.0000 | 0.0580 | 0.2028 | 0.8847 | |
| HCC1187 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 10753.154 | uM | inf | inf | 1.0162 | 1.0162 | 0.0000 | -0.0376 | -5.9291 | 1.4444 | |
| HCC1187 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 10518.142 | uM | inf | inf | 0.9343 | 0.9343 | 0.0000 | 0.0364 | -0.0557 | 1.2869 | |
| LY2 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 10264.026 | uM | inf | inf | 0.9706 | 0.9706 | 0.0000 | -0.0006 | 0.1039 | 1.5047 | |
| MDA-MB-361 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 7508.066 | uM | inf | inf | 0.8080 | 0.8080 | 0.0000 | 0.1475 | 0.5518 | 0.8980 | |
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9146.049 | uM | inf | inf | 0.5485 | 0.5485 | 0.0000 | 0.3293 | 0.0796 | 1.1054 | |
| HCC3153 | TNBC | Basal A | GW843682X | PLK | PLK | 10577.139 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0263 | -0.5932 | 0.9234 | |
| HCC38 | TNBC | Basal B | TCS PIM-1 1 | Pim kinase | PIM | 10578.135 | uM | inf | inf | 0.9081 | 0.9081 | 0.0000 | 0.0395 | 0.0248 | 1.7650 | |
| HCC202 | HER2amp | Luminal | Disulfiram | Proteasome | Proteasome | 13135.174 | uM | inf | inf | -0.5009 | -0.5009 | 0.0000 | 0.5075 | 0.5614 | 0.5256 | |
| HCC202 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 7458.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0275 | -0.6310 | 0.4917 | |
| MDA-MB-134-VI | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 10998.144 | uM | inf | inf | 0.8777 | 0.8777 | 0.0000 | 0.0210 | 0.4718 | 0.8153 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 10873.148 | uM | inf | inf | 0.9161 | 0.9161 | 0.0000 | 0.1719 | 0.0430 | 1.2150 | |
| MDA-MB-361 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 7508.065 | uM | inf | inf | 1.0103 | 1.0103 | 0.0000 | 0.0104 | 0.0000 | 0.7854 | |
| MCF12A | NM | Basal B | Nilotinib | ABL | nRTK | 10817.145 | uM | inf | inf | 0.9556 | 0.9556 | 0.0000 | 0.0393 | 0.0596 | 1.5564 | |
| HCC38 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 11850.155 | uM | inf | inf | 0.5069 | 0.5069 | 0.0000 | 0.3134 | 0.5180 | 2.1810 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 7458.091 | uM | inf | inf | 1.0005 | 1.0005 | 0.0000 | 0.1959 | 0.0969 | 0.5499 | |
| MDA-MB-415 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7511.098 | uM | inf | inf | 0.9618 | 0.9618 | 0.0000 | 0.0309 | 0.2078 | 1.2032 | |
| MDA-MB-415 | HR+ | Luminal | AG1024 | IGF1R | RTK | 7512.066 | uM | inf | inf | 0.9738 | 0.9738 | 0.0000 | -0.0064 | -0.0661 | 0.8629 | |
| Hs 578T | TNBC | Basal B | PS-1145 | IKK | NFKB | 7475.065 | uM | inf | inf | 1.0453 | 1.0453 | 0.0000 | -0.0447 | -24.5864 | 2.6262 | |
| HCC1143 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7809.016 | uM | inf | inf | 0.3854 | 0.3854 | 0.0000 | 0.1556 | 0.5101 | 1.6622 | ||
| MDA-MB-175-VII | HR+ | Luminal | Celecoxib | COX2 | COX | 10642.136 | uM | inf | inf | 0.5259 | 0.5259 | 0.0000 | 0.1780 | 0.0542 | 0.5193 | |
| HCC1954 | HER2amp | Basal A | PS-1145 | IKK | NFKB | 7457.065 | uM | inf | inf | 0.8494 | 0.8494 | 0.0000 | 0.0471 | 0.0632 | 1.5870 | |
| MDA-MB-175-VII | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 7499.084 | uM | inf | inf | 0.8028 | 0.8028 | 0.0000 | 0.0973 | -0.0768 | 0.7991 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 12319.166 | uM | inf | inf | 0.6126 | 0.6126 | 0.0000 | 0.2273 | 0.0745 | 1.3789 |