Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
184A1 | NM | Basal | GSK1838705A | IGF1R | RTK | 5895.091 | uM | 0.38664 | 0.64104 | -0.6029 | -0.4621 | 1.2945 | 0.5672 | 0.9684 | 1.1729 | |
184A1 | NM | Basal | GSK1070916 | AURK | AURK | 10002.001 | uM | 0.64737 | 2.67080 | -0.5505 | -0.8031 | 0.6759 | 0.3916 | 0.9922 | 0.5372 | |
184A1 | NM | Basal | CPT-11 | TOP1 | TOP | 9047.121 | uM | 3.33380 | 6.76440 | -0.6694 | -0.7837 | 1.3326 | 0.4789 | 0.9103 | 0.7949 | |
184A1 | NM | Basal | GM6001 | MMP | MMP | 5895.096 | uM | inf | inf | 0.9763 | 0.9763 | 0.0000 | -0.0141 | -0.1057 | 1.4232 | |
184A1 | NM | Basal | Glycyl-H-1152 | ROCK2 | 12509.169 | uM | inf | inf | 0.8820 | 0.8820 | 0.0000 | 0.0673 | 0.0092 | 1.5064 | ||
184A1 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 9047.011 | uM | 0.39288 | 3.58790 | -0.7197 | -1.0000 | 0.4967 | 0.6665 | 0.9520 | 0.6293 | |
184A1 | NM | Basal | Geldanamycin | HSP90 | HSP90 | 10002.012 | uM | 0.00232 | 0.00278 | -0.4963 | -0.4694 | 3.6140 | 1.2014 | 0.9946 | 0.5807 | |
184A1 | NM | Basal | Cisplatin | DNA cross-linker | DNA cross-linker | 9047.017 | uM | 2.85670 | 3.92150 | -0.9940 | -0.8307 | 3.0896 | 0.5793 | 0.9882 | 0.8440 | |
184A1 | NM | Basal | Gefitinib | EGFR | ErbB | 9047.132 | uM | inf | inf | 0.4414 | 0.4414 | 0.0000 | 0.4398 | 0.3588 | 0.6985 | |
184A1 | NM | Basal | CGC-11047 | Polyamine analogue | 7787.018 | uM | 839.83530 | 1000.00000 | -0.8398 | -0.6967 | 5.0000 | 0.2577 | 0.8874 | 0.3791 | ||
184A1 | NM | Basal | FR180204 | ERK1/2 | MAPK | 12509.166 | uM | 30.45440 | 25.56580 | 0.2919 | 0.2912 | 4.9895 | 0.0565 | 0.9495 | 1.2847 | |
184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 5894.084 | uM | 0.44564 | 0.69098 | -0.9438 | -0.9392 | 2.4104 | 0.5734 | 0.9993 | 1.5903 | |
184A1 | NM | Basal | CGC-11047 | Polyamine analogue | 10002.034 | uM | 242.78660 | 399.08510 | -0.9907 | -1.0000 | 2.2105 | 0.6269 | 0.7996 | 0.6736 | ||
184A1 | NM | Basal | Everolimus | MTOR | MTOR | 12509.164 | uM | 0.02317 | 2.80470 | -0.9610 | -1.0000 | 0.2291 | 0.6861 | 0.6516 | 1.1949 | |
184A1 | NM | Basal | Etoposide | TOP2 | TOP | 5895.074 | uM | 10.48650 | 42.19930 | -0.7395 | -1.0000 | 0.7891 | 0.3710 | 0.9859 | 1.1218 | |
184A1 | NM | Basal | Etoposide | TOP2 | TOP | 5894.074 | uM | 9.28560 | 35.69030 | -0.7680 | -1.0000 | 0.8160 | 0.4044 | 0.9826 | 1.4541 | |
184A1 | NM | Basal | Erlotinib | EGFR | ErbB | 5895.091 | uM | 0.20794 | 0.22424 | -0.1773 | -0.1482 | 3.4384 | 0.4858 | 0.9969 | 1.1729 | |
184A1 | NM | Basal | Epirubicin | TOP2 | TOP | 9047.017 | uM | 0.20465 | 0.50611 | -0.9999 | -0.9734 | 1.1936 | 0.8841 | 0.9887 | 0.8440 | |
21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14607.189 | uM | 0.09589 | 0.20341 | -0.9029 | -0.9017 | 1.3707 | 0.8886 | 0.9922 | 1.3733 | |
184A1 | NM | Basal | Vorinostat | HDAC | HDAC | 5895.065 | uM | 141.55360 | 735.01640 | -0.6699 | -0.8793 | 0.6160 | 0.4840 | 0.9909 | 1.3748 | |
184A1 | NM | Basal | Docetaxel | TUBB | TUBB | 12684.002 | uM | inf | 0.00450 | 0.5376 | 0.5289 | 1.1663 | 0.2796 | 0.9570 | 1.5245 | |
184A1 | NM | Basal | Docetaxel | TUBB | TUBB | 10002.002 | uM | inf | 0.00813 | 0.5141 | 0.5151 | 1.4431 | 0.2780 | 0.7979 | 0.9502 | |
184A1 | NM | Basal | Docetaxel | TUBB | TUBB | 9047.002 | uM | 0.00721 | 0.00164 | 0.3271 | 0.2689 | 0.5211 | 0.4844 | 0.7111 | 0.5243 | |
184A1 | NM | Basal | Disulfiram | Proteasome | Proteasome | 12684.174 | uM | 14.63270 | 13.50790 | 0.1987 | 0.0386 | 1.0041 | 0.1179 | 0.9898 | 1.4645 | |
184A1 | NM | Basal | Dichloroacetate | PDK | PDK | 12684.176 | uM | inf | inf | 0.9148 | 0.9148 | 0.0000 | 0.0449 | 0.1851 | 1.3650 |