Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9972.011 | uM | 2.95190 | 17.1170 | -0.8648 | -1.0000 | 0.6251 | 0.5673 | 0.9554 | 0.9432 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 9997.024 | uM | 7.45070 | 7.79640 | -0.1265 | -0.1273 | 4.9980 | 0.1364 | 0.8935 | 0.9704 | |
| ZR75B | HR+ | Luminal | NU6102 | CDK1/2 | CDK | 11939.147 | uM | 16.16020 | 26.60070 | -0.2441 | -0.5569 | 1.5018 | 0.1555 | 0.9891 | 1.6102 | |
| ZR75B | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11939.16 | uM | 0.24883 | 0.07353 | 0.2384 | 0.3689 | 1.0978 | 0.2938 | 0.9233 | 1.6749 | |
| ZR75B | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 13595.174 | uM | 0.22129 | 0.11078 | 0.0054 | 0.4843 | 5.0000 | 0.2262 | 0.5901 | 1.8596 | |
| ZR75B | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14149.189 | uM | 3.5340 | 4.77460 | -0.1522 | -0.2083 | 1.1576 | 0.2857 | 0.9859 | 2.1888 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 9972.011 | uM | 0.04303 | 0.03632 | 0.2284 | 0.2858 | 4.9991 | 0.4512 | 0.9803 | 0.9432 | |
| ZR75B | HR+ | Luminal | Nilotinib | ABL | nRTK | 11939.145 | uM | inf | inf | 0.9109 | 0.9109 | 0.0000 | 0.0508 | 0.0110 | 1.6830 | |
| ZR75B | HR+ | Luminal | PS-1145 | IKK | NFKB | 7555.065 | uM | inf | inf | 1.0207 | 1.0207 | 0.0000 | 0.0155 | 0.0000 | 1.7561 | |
| ZR75B | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9997.011 | uM | 2.57590 | 22.18760 | -0.7360 | -1.0000 | 0.5102 | 0.5453 | 0.9593 | 1.0551 | |
| ZR75B | HR+ | Luminal | L-779450 | BRAF | MAPK | 11939.161 | uM | 30.47680 | 54.02740 | 0.0732 | -1.0000 | 1.9189 | 0.0857 | 0.9587 | 1.6513 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 9972.121 | uM | 0.03233 | 0.69881 | -0.8479 | -1.0000 | 0.3575 | 0.8191 | 0.9575 | 1.1034 | |
| ZR75B | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 11939.154 | uM | 0.57077 | 5.33890 | -0.5541 | -1.0000 | 0.4914 | 0.4104 | 0.9580 | 1.7246 | |
| ZR75B | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7555.091 | uM | 28.04830 | 43.60380 | -0.8997 | -0.9016 | 2.3362 | 0.3595 | 0.9986 | 1.6040 | |
| ZR75B | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9972.125 | uM | 4.30080 | 14.18760 | 0.8594 | -0.8482 | 0.8310 | 0.0135 | 0.6892 | 1.1854 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9972.017 | uM | 15.96770 | 42.6540 | -0.7631 | -1.0000 | 1.1181 | 0.2804 | 0.9966 | 1.1666 | |
| ZR75B | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 7555.065 | uM | 5.670 | 11.72190 | -0.6834 | -0.6554 | 1.1533 | 0.7880 | 0.9984 | 1.7561 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 9997.037 | uM | 0.11058 | 0.20364 | -0.4591 | -0.2188 | 0.5944 | 0.5503 | 0.9139 | 1.2339 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 9997.121 | uM | 0.11486 | 1.6340 | -0.8510 | -1.0000 | 0.4138 | 0.7060 | 0.9353 | 1.1121 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9997.049 | uM | inf | inf | 0.9585 | 0.9585 | 0.0000 | 0.0082 | 0.0001 | 1.1423 | |
| ZR75B | HR+ | Luminal | Trametinib | MEK | MAPK | 9972.012 | uM | inf | 0.02709 | 0.6265 | 0.6824 | 0.4873 | 0.1498 | 0.8722 | 1.1986 | |
| ZR75B | HR+ | Luminal | 5-FU | TYMS | TYMS | 9972.017 | uM | 6.61280 | 415.5050 | -0.5105 | -1.0000 | 0.2653 | 0.7315 | 0.8568 | 1.1666 | |
| ZR75B | HR+ | Luminal | Taxol | TUBB | TUBB | 9972.002 | uM | 0.00755 | 0.00610 | 0.1087 | 0.1821 | 2.1270 | 0.5439 | 0.9847 | 1.0054 |