Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7552.095 | uM | 283.16160 | 264.75520 | 0.1397 | 0.1427 | 5.0000 | 0.2204 | 0.9126 | 1.1106 | |
| ZR-75-1 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 7931.017 | uM | 0.30996 | 3.43680 | -0.9634 | -1.0000 | 0.4566 | 0.6270 | 0.8953 | 1.3488 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 7932.001 | uM | 8.94240 | 7.61130 | 0.2743 | 0.2737 | 4.9198 | 0.1129 | 0.8952 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 7931.011 | uM | 0.05667 | 0.02512 | 0.3168 | 0.4236 | 2.3080 | 0.3854 | 0.9628 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7553.074 | uM | 0.11265 | 0.19850 | -0.7439 | -0.6288 | 1.4376 | 0.8537 | 0.9801 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7553.095 | uM | 0.08527 | 2.84440 | -0.9700 | -1.0000 | 0.3132 | 0.5455 | 0.6946 | 1.1473 | |
| ZR-75-1 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 12003.147 | uM | 6.41970 | 6.39740 | -0.1672 | 0.0086 | 5.0000 | 0.3163 | 0.8655 | 1.1884 | |
| ZR-75-1 | HR+ | Luminal | Everolimus | MTOR | MTOR | 12003.164 | uM | 0.02561 | 0.03003 | -0.1277 | -0.0475 | 0.5701 | 0.6142 | 0.9704 | 0.9505 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 7552.065 | uM | 151.22690 | 275.77280 | -0.4434 | -0.4546 | 1.0764 | 0.4901 | 0.9835 | 1.1323 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 12003.167 | uM | 0.06810 | 0.20743 | -0.2023 | -0.3669 | 0.4941 | 0.5643 | 0.9694 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 7552.066 | uM | 3.24430 | 16.45390 | -0.4580 | -1.0000 | 0.6766 | 0.3325 | 0.9736 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 12003.159 | uM | inf | inf | 0.4060 | 0.4060 | 0.0000 | 0.2531 | 0.490 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 7553.086 | uM | 0.00624 | 0.01999 | -0.7384 | -0.6927 | 0.7464 | 0.9756 | 0.9947 | 1.0750 | |
| ZR-75-1 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 11660.148 | uM | inf | inf | 0.4628 | 0.4628 | 0.0000 | 0.1626 | 0.3081 | 1.1480 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 7552.084 | uM | 0.02302 | 0.01642 | 0.3234 | 0.3625 | 3.8221 | 0.4995 | 0.9792 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 12003.166 | uM | 1.95110 | 169.06310 | -0.0471 | -1.0000 | 0.2462 | 0.3907 | 0.7596 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 11660.147 | uM | 2.21290 | 6.05560 | -0.9635 | -1.0000 | 1.0913 | 0.4442 | 0.9788 | 1.0592 | |
| ZR-75-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 9958.012 | uM | 19.68590 | 17.35330 | 0.6507 | 0.2298 | 4.8786 | 0.0043 | 0.9189 | 0.5705 | |
| ZR-75-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 12003.165 | uM | 5.44130 | 4.51610 | 0.1734 | 0.1126 | 1.3697 | 0.2139 | 0.8333 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | NU6102 | CDK1/2 | CDK | 12003.147 | uM | 6.9470 | 21.39630 | -0.5767 | -1.0000 | 0.9766 | 0.3650 | 0.8273 | 1.1884 | |
| ZR-75-1 | HR+ | Luminal | QNZ | NFkB | NFKB | 7553.096 | uM | 0.05947 | 0.02437 | 0.2664 | 0.3269 | 1.1891 | 0.3945 | 0.9421 | 1.1407 | |
| ZR-75-1 | HR+ | Luminal | Etoposide | TOP2 | TOP | 7552.074 | uM | 1.85260 | 5.54480 | -0.4465 | -0.5092 | 0.6406 | 0.4842 | 0.9913 | 0.9174 | |
| ZR-75-1 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 12003.168 | uM | 6.51220 | 2.50280 | 0.4806 | 0.4958 | 5.0000 | 0.2143 | 0.8277 | 1.1370 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 7553.093 | uM | inf | inf | 0.7412 | 0.7412 | 0.0000 | 0.1112 | 0.2063 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7552.098 | uM | 412.73890 | 81.38380 | 0.5312 | 0.1320 | 0.1887 | 0.2172 | 0.7668 | 1.1882 |