Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 12003.135 | uM | 0.78281 | 0.50730 | 0.1934 | 0.0727 | 0.3619 | 0.3755 | 0.9268 | 0.9898 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11660.15 | uM | 2.44570 | 66.64330 | -0.0071 | -1.0000 | 0.3324 | 0.2920 | 0.8631 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7553.091 | uM | inf | inf | 0.9665 | 0.9665 | 0.0000 | -0.0228 | -0.3323 | 0.9738 | |
| ZR-75-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 11660.145 | uM | 0.47233 | 1.21540 | -0.8693 | -0.8719 | 1.0678 | 0.5829 | 0.9976 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 7932.043 | uM | 0.12271 | 0.25988 | -0.7083 | -0.5033 | 0.9281 | 0.6673 | 0.9471 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 7932.011 | uM | 0.02338 | 0.02080 | -0.0531 | 0.1219 | 2.3909 | 0.5838 | 0.9535 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | 2-deoxyglucose | 12677.177 | uM | inf | inf | 0.3935 | 0.3935 | 0.0000 | 0.2078 | 0.3077 | 1.0515 | |||
| ZR-75-1 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7552.067 | uM | 10.03460 | 12.54540 | -0.9796 | -0.9797 | 4.8587 | 0.3735 | 0.9983 | 1.0224 | |
| ZR-75-1 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 11660.143 | uM | 739.35260 | 1000.00000 | -0.7032 | -0.2500 | 1.3425 | 0.2387 | 0.7593 | 1.0389 | |
| ZR-75-1 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14296.189 | uM | 1.89760 | 2.50260 | -0.9364 | -0.9212 | 3.7751 | 0.5470 | 0.9892 | 0.6639 | |
| ZR-75-1 | HR+ | Luminal | Nilotinib | ABL | nRTK | 12003.145 | uM | inf | inf | 0.9728 | 0.9728 | 0.0000 | 0.0104 | 0.0000 | 0.9611 | |
| ZR-75-1 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7552.074 | uM | 0.13222 | 0.32325 | -0.7900 | -0.7103 | 0.9889 | 0.7952 | 0.9760 | 0.9174 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12003.167 | uM | 1.41090 | 10.49420 | -0.3709 | -1.0000 | 0.5475 | 0.3641 | 0.9076 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | Triciribine | AKT | AKT | 7553.074 | uM | 10.22730 | 73.93430 | 0.2175 | -1.0000 | 0.5554 | 0.1841 | 0.8701 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 12677.177 | uM | 0.10357 | 0.14167 | -0.9831 | -0.9756 | 3.4545 | 0.8644 | 0.9986 | 1.0515 | |
| ZR-75-1 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7931.042 | uM | inf | inf | 0.8278 | 0.8278 | 0.0000 | -0.0111 | 0.4074 | 1.3878 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 11660.154 | uM | 1.28590 | 10.59590 | -0.3306 | -1.0000 | 0.5209 | 0.3588 | 0.9488 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 12003.147 | uM | 1.75560 | 8.28140 | -0.8786 | -1.0000 | 0.7082 | 0.4604 | 0.8990 | 1.1884 | |
| ZR-75-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 11660.146 | uM | 583.9090 | 1000.00000 | 0.4704 | -0.0361 | 0.1295 | 0.2471 | 0.6207 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 11660.149 | uM | inf | inf | 0.7903 | 0.7903 | 0.0000 | 0.1532 | 0.0592 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 11660.145 | uM | 5.16470 | 8.72860 | -0.9838 | -0.9998 | 2.0932 | 0.4186 | 0.9930 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | AG1478 | EGFR | ErbB | 7932.016 | uM | 175.56330 | 175.46780 | 0.5616 | 0.0014 | 4.9999 | 0.0271 | 0.7988 | 0.6446 | |
| ZR-75-1 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 7932.052 | uM | 0.02137 | 0.17670 | -0.8958 | -0.7487 | 0.4333 | 0.7300 | 0.8880 | 0.8877 | |
| ZR-75-1 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 12003.167 | uM | inf | inf | 0.7304 | 0.7304 | 0.0000 | 0.2250 | -0.0343 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 11660.151 | uM | inf | inf | 0.6460 | 0.6460 | 0.0000 | 0.1792 | 0.5635 | 0.9483 |