Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9972.125 | uM | 4.30080 | 14.18760 | 0.8594 | -0.8482 | 0.8310 | 0.0135 | 0.6892 | 1.1854 | |
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9972.125 | uM | 62.05340 | 1000.00000 | -0.5139 | -0.9610 | 0.3858 | 0.3920 | 0.8676 | 1.1854 | ||
| ZR75B | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9997.001 | uM | 0.13661 | 2.1940 | -0.6969 | -1.0000 | 0.3957 | 0.4891 | 0.8692 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9997.001 | uM | 0.04836 | 0.03537 | 0.0463 | 0.2487 | 2.1998 | 0.3757 | 0.9454 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 9997.001 | uM | 2.23530 | 37.82990 | -0.0603 | -1.0000 | 0.3884 | 0.2879 | 0.8395 | 1.0003 | |
| ZR75B | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9997.002 | uM | 0.03585 | 0.01281 | 0.4029 | 0.4354 | 1.9886 | 0.2785 | 0.9894 | 0.9751 | |
| ZR75B | HR+ | Luminal | Taxol | TUBB | TUBB | 9997.002 | uM | 0.10845 | 0.04289 | 0.1042 | 0.2100 | 0.5873 | 0.3883 | 0.8980 | 0.9751 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9997.011 | uM | 392.17980 | 716.46410 | -0.5311 | -1.0000 | 1.8231 | 0.1305 | 0.9710 | 1.0551 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 9997.011 | uM | 0.03217 | 0.01921 | 0.4132 | 0.4620 | 4.9943 | 0.3567 | 0.9393 | 1.0551 | |
| ZR75B | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9997.011 | uM | 2.57590 | 22.18760 | -0.7360 | -1.0000 | 0.5102 | 0.5453 | 0.9593 | 1.0551 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 9997.024 | uM | 7.45070 | 7.79640 | -0.1265 | -0.1273 | 4.9980 | 0.1364 | 0.8935 | 0.9704 | |
| ZR75B | HR+ | Luminal | Trametinib | MEK | MAPK | 9997.024 | uM | inf | 999.97430 | 0.6471 | -0.1387 | 0.2260 | 0.1193 | 0.5969 | 0.9704 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9997.024 | uM | 0.08448 | 0.0930 | -0.1253 | -0.0437 | 0.8720 | 0.5416 | 0.9774 | 0.9704 | |
| ZR75B | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 9997.026 | uM | 10.14060 | 9.03470 | 0.8100 | 0.2193 | 4.9983 | -0.0116 | 0.7236 | 1.1348 | |
| ZR75B | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9997.026 | uM | inf | inf | 0.9578 | 0.9578 | 0.0000 | -0.0328 | -0.7332 | 1.1348 | |
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9997.026 | uM | 694.32460 | 1000.00000 | -0.6676 | -0.5458 | 2.0226 | 0.2645 | 0.8363 | 1.1348 | ||
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 9997.037 | uM | 0.11058 | 0.20364 | -0.4591 | -0.2188 | 0.5944 | 0.5503 | 0.9139 | 1.2339 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 9997.049 | uM | inf | inf | 0.7909 | 0.7909 | 0.0000 | 0.0483 | 0.3558 | 1.1423 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9997.049 | uM | inf | inf | 0.9585 | 0.9585 | 0.0000 | 0.0082 | 0.0001 | 1.1423 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9997.049 | uM | 0.10140 | 0.04753 | 0.1808 | 0.3301 | 1.4243 | 0.3756 | 0.8932 | 1.1423 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 9997.121 | uM | 0.40220 | 0.87378 | -0.9219 | -0.7766 | 1.2081 | 0.6199 | 0.9828 | 1.1121 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 9997.121 | uM | 0.11486 | 1.6340 | -0.8510 | -1.0000 | 0.4138 | 0.7060 | 0.9353 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 9997.121 | uM | 1.66170 | 0.86071 | 0.2842 | 0.3340 | 1.6759 | 0.2165 | 0.9826 | 1.1121 |