Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 9420.012 | uM | 11.78230 | 14.67580 | -0.3118 | -0.9991 | 5.0000 | 0.2592 | 0.6528 | 0.3162 | |
| HCC2185 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 9420.037 | uM | 0.07080 | 0.10739 | -0.9778 | -0.8569 | 2.3960 | 0.9873 | 0.9872 | 0.3864 | |
| HCC2185 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 9420.132 | uM | inf | inf | 0.4783 | 0.4783 | 0.0000 | 0.1427 | 0.1330 | 0.3309 | |
| HCC2185 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 9420.132 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0075 | -0.0001 | 0.3309 | ||
| HCC2185 | TNBC | Luminal | Taxol | TUBB | TUBB | 9421.002 | uM | 0.00536 | 0.00657 | -0.3820 | -0.3593 | 2.6615 | 0.9054 | 0.9972 | 0.5336 | |
| HCC2185 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 9421.002 | uM | 0.00299 | 0.00321 | -0.1006 | -0.2178 | 5.0000 | 0.7705 | 0.9793 | 0.5336 | |
| HCC2185 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 9421.012 | uM | 0.01269 | 0.01626 | -0.6402 | -0.5013 | 2.8041 | 1.0282 | 0.9879 | 0.7153 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 9421.012 | uM | inf | 999.78290 | 0.5751 | -0.0451 | 0.1524 | 0.1932 | 0.5850 | 0.7153 | |
| HCC2185 | TNBC | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9421.021 | uM | 3.32830 | 5.08560 | -1.0000 | -0.9677 | 2.5400 | 0.7050 | 0.9975 | 0.3726 | |
| HCC2185 | TNBC | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9421.021 | uM | 13.02370 | 26.1650 | -1.0000 | -1.0000 | 1.5747 | 0.5987 | 0.9904 | 0.3726 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9421.021 | uM | 1.64960 | 2.88290 | -1.0000 | -0.9906 | 1.9565 | 0.6753 | 0.9969 | 0.3726 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 9421.034 | uM | 0.06107 | 0.24961 | -0.9990 | -0.9959 | 0.7784 | 0.9110 | 0.9962 | 0.6220 | |
| HCC2185 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 9421.034 | uM | 8.90130 | 310.67280 | -0.9800 | -1.0000 | 0.3093 | 0.5866 | 0.7305 | 0.6220 | ||
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 9421.034 | uM | 4.04040 | 4.15410 | -0.0256 | -0.0184 | 1.2999 | 0.2027 | 0.9875 | 0.6220 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 9453.001 | uM | 0.18090 | 1.87020 | -0.9029 | -1.0000 | 0.4703 | 0.5168 | 0.9195 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 9453.001 | uM | 0.02992 | 0.03334 | -0.3514 | -0.2339 | 3.5495 | 0.6684 | 0.9929 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 9453.001 | uM | 0.04334 | 0.05796 | -0.4788 | -0.3827 | 1.9551 | 0.6790 | 0.9943 | 1.2616 | |
| HCC38 | TNBC | Basal B | Taxol | TUBB | TUBB | 9453.002 | uM | 0.00667 | 0.01032 | -0.5756 | -0.5492 | 1.6962 | 0.9840 | 0.9969 | 1.2655 | |
| HCC38 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 9453.002 | uM | 0.00155 | 0.00206 | -0.4437 | -0.4476 | 2.2476 | 0.9688 | 0.9960 | 1.2655 | |
| HCC38 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9453.011 | uM | 0.01981 | 0.02434 | -0.9070 | -0.9002 | 5.0000 | 1.2811 | 0.9987 | 0.7773 | |
| HCC38 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9453.011 | uM | 7.91820 | 17.01960 | -0.9837 | -1.0000 | 1.4357 | 0.5359 | 0.9966 | 0.7773 | |
| HCC38 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 9453.011 | uM | 34.80390 | 42.89210 | -0.9585 | -0.9214 | 5.0000 | 0.5058 | 0.9973 | 0.7773 | |
| HCC38 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 9453.012 | uM | 0.01962 | 0.02148 | -0.4082 | -0.2047 | 3.7918 | 0.7809 | 0.9256 | 1.2055 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 9453.012 | uM | inf | inf | 0.9034 | 0.9034 | 0.0000 | -0.0001 | 0.4116 | 1.2055 | |
| HCC38 | TNBC | Basal B | 5-FU | TYMS | TYMS | 9453.017 | uM | 204.98770 | 867.09230 | -0.5306 | -0.7483 | 0.6344 | 0.4287 | 0.9866 | 1.2279 |