Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC3153 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 10056.021 | uM | 8.47820 | 15.30870 | -0.9575 | -0.9929 | 1.8511 | 0.4902 | 0.9885 | 0.8839 | |
| HCC3153 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 10056.034 | uM | 4.94730 | 53.82750 | -0.9867 | -1.0000 | 0.4603 | 0.7287 | 0.9511 | 0.8648 | ||
| HCC3153 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 10056.034 | uM | 17.11390 | 33.29250 | -0.5855 | -1.0000 | 1.6509 | 0.1346 | 0.9910 | 0.8648 | |
| HCC3153 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 10056.034 | uM | 0.47320 | 0.88785 | -0.9212 | -0.8902 | 1.6250 | 0.6566 | 0.9982 | 0.8648 | |
| MCF12A | NM | Basal B | GSK923295 | CENPE | Kinesin | 10061.001 | uM | 2.01520 | 9.19330 | -0.7674 | -1.0000 | 0.7238 | 0.3226 | 0.8034 | 1.7406 | |
| MCF12A | NM | Basal B | GSK1070916 | AURK | AURK | 10061.001 | uM | 7.05180 | 18.47620 | -0.3544 | -1.0000 | 1.1406 | 0.2085 | 0.9378 | 1.7406 | |
| MCF12A | NM | Basal B | GSK461364 | PLK1 | PLK | 10061.001 | uM | 1.47950 | 7.65830 | -0.8558 | -1.0000 | 0.6682 | 0.3189 | 0.8112 | 1.7406 | |
| MCF12A | NM | Basal B | Docetaxel | TUBB | TUBB | 10061.002 | uM | 0.03596 | 0.00551 | 0.4666 | 0.4502 | 1.2301 | 0.3153 | 0.9765 | 1.8759 | |
| MCF12A | NM | Basal B | Taxol | TUBB | TUBB | 10061.002 | uM | 0.02796 | 0.01249 | 0.1491 | 0.3357 | 1.3814 | 0.3870 | 0.9179 | 1.8759 | |
| MCF12A | NM | Basal B | 17-AAG | HSP90 | HSP90 | 10061.037 | uM | 0.03509 | 0.03844 | -0.6495 | -0.2882 | 5.0000 | 0.8377 | 0.6366 | 1.7478 | |
| MCF12A | NM | Basal B | Gefitinib | EGFR | ErbB | 10061.049 | uM | 0.87261 | 3.62350 | -0.8055 | -1.0000 | 0.7717 | 0.3691 | 0.9583 | 1.7845 | |
| MCF12A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 10061.049 | uM | 0.02306 | 0.03084 | -0.5939 | -0.5800 | 2.6507 | 0.9816 | 0.9988 | 1.7845 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 10061.049 | uM | inf | 651.48010 | 0.8972 | 0.5117 | 4.9986 | -0.0089 | 0.6029 | 1.7845 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 10061.12 | uM | 0.28867 | 0.25213 | 0.0671 | 0.0377 | 0.5785 | 0.4089 | 0.9672 | 2.0669 | |
| MCF12A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 10061.12 | uM | 180.30870 | 388.26890 | -0.7598 | -1.0000 | 1.4323 | 0.2270 | 0.9929 | 2.0669 | |
| MCF12A | NM | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10061.12 | uM | 4.1260 | 26.98840 | -0.7649 | -1.0000 | 0.5850 | 0.5535 | 0.9255 | 2.0669 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 10061.121 | uM | 0.14208 | 0.22393 | -0.8447 | -0.8402 | 2.1671 | 0.8756 | 0.9950 | 1.9364 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 10061.121 | uM | 2.59920 | 8.08440 | -0.2192 | -0.4707 | 0.5847 | 0.2889 | 0.9746 | 1.9364 | |
| MCF12A | NM | Basal B | Topotecan | TOP1 | TOP | 10061.121 | uM | 0.07619 | 0.55398 | -0.8083 | -0.9793 | 0.5467 | 0.8270 | 0.9781 | 1.9364 | |
| MCF12A | NM | Basal B | Trastuzumab | HER2 | ErbB | 10061.123 | uM | 17.14380 | 8.78160 | 0.8599 | 0.4824 | 4.9997 | -0.0107 | 0.7497 | 1.9064 | |
| MCF12A | NM | Basal B | CGC-11047 | Polyamine analogue | 10061.123 | uM | inf | 1.94010 | 0.5944 | 0.5842 | 0.7640 | 0.1252 | 0.9147 | 1.9064 | ||
| MCF12A | NM | Basal B | Cetuximab | EGFR | ErbB | 10061.123 | uM | 1.02740 | 2.52820 | 0.6599 | -0.9860 | 1.2097 | 0.0245 | 0.9609 | 1.9064 | |
| MCF7 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 10073.001 | uM | 1.43130 | 16.74890 | -0.3255 | -1.0000 | 0.4466 | 0.3080 | 0.9058 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 10073.001 | uM | 0.60343 | 7.16960 | -0.9451 | -1.0000 | 0.4439 | 0.4232 | 0.5927 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 10073.001 | uM | 10.70090 | 17.87270 | -0.5853 | -1.0000 | 2.1418 | 0.2123 | 0.9462 | 0.5923 |