Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Gemcitabine | DNA replication | DNA replication | 7848.011 | uM | 0.0180 | 0.02052 | -0.3401 | -0.1962 | 2.5228 | 0.8366 | 0.9645 | 0.3405 | |
| HCC2185 | TNBC | Luminal | Glycyl-H-1152 | ROCK2 | 12192.16 | uM | 3.80670 | 5.47010 | -0.1440 | -0.2253 | 1.0261 | 0.2659 | 0.9286 | 0.7363 | ||
| HCC2185 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 7849.002 | uM | 0.00354 | 0.00355 | 0.0715 | -0.0010 | 1.5701 | 0.6158 | 0.9724 | 0.5525 | |
| HCC2185 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 9421.012 | uM | 0.01269 | 0.01626 | -0.6402 | -0.5013 | 2.8041 | 1.0282 | 0.9879 | 0.7153 | |
| 184A1 | NM | Basal | GSK1838705A | IGF1R | RTK | 5895.098 | uM | 0.42849 | 0.39937 | 0.0166 | 0.0538 | 1.6165 | 0.3574 | 0.9937 | 1.4041 | |
| 184A1 | NM | Basal | Sirolimus | MTOR | MTOR | 7787.068 | uM | inf | inf | -0.2794 | -0.2794 | 0.0000 | 0.5821 | 0.4995 | 0.9562 | |
| 184A1 | NM | Basal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5895.085 | uM | 1.60350 | 2.04080 | -0.6352 | -0.4548 | 2.6820 | 0.5481 | 0.9684 | 1.4396 | |
| HCC2185 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 9420.012 | uM | 0.01386 | 0.01703 | -0.9643 | -0.9044 | 5.0000 | 1.3001 | 0.9964 | 0.3162 | |
| 184A1 | NM | Basal | Dactolisib | PI3K | PI3K | 12509.155 | uM | 0.06399 | 0.05482 | 0.0859 | 0.0731 | 1.0226 | 0.4688 | 0.9812 | 1.3444 | |
| 184A1 | NM | Basal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5894.067 | uM | 4.440 | 8.19730 | -0.9413 | -0.9957 | 1.7870 | 0.4582 | 0.9949 | 1.5647 | |
| HCC2185 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 9421.002 | uM | 0.00299 | 0.00321 | -0.1006 | -0.2178 | 5.0000 | 0.7705 | 0.9793 | 0.5336 | |
| HCC2185 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 7846.016 | uM | 8.07560 | 13.51120 | -0.7529 | -1.0000 | 2.1346 | 0.2060 | 0.9492 | 0.3279 | |
| 184A1 | NM | Basal | GSK461364 | PLK1 | PLK | 9047.001 | uM | 4.15810 | 52.44110 | -0.0073 | -1.0000 | 0.4334 | 0.2620 | 0.7464 | 0.7701 | |
| 184A1 | NM | Basal | TAPI-0 | TACE/Collagenase | 5895.096 | uM | inf | 6.62580 | 0.8804 | 0.8803 | 5.0000 | -0.0065 | 0.5959 | 1.4232 | ||
| HCC2185 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 7845.016 | uM | 10.09720 | 20.57540 | -0.3643 | -1.0000 | 1.5433 | 0.2562 | 0.7917 | 0.4392 | |
| 184A1 | NM | Basal | Taxol | TUBB | TUBB | 9047.002 | uM | 0.05134 | 0.13706 | -0.1958 | -0.2758 | 0.4473 | 0.5388 | 0.9220 | 0.5243 | |
| HCC2185 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 7849.016 | uM | 7.58790 | 17.96450 | -0.3800 | -1.0000 | 1.2747 | 0.1672 | 0.9784 | 0.3419 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 9421.034 | uM | 4.04040 | 4.15410 | -0.0256 | -0.0184 | 1.2999 | 0.2027 | 0.9875 | 0.6220 | |
| HCC2185 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 7464.084 | uM | 0.12235 | 0.24577 | -0.9958 | -1.0000 | 1.5751 | 0.7922 | 0.9942 | 0.8152 | |
| 184A1 | NM | Basal | 5-DFUR | TYMS | TYMS | 12509.143 | uM | 228.63720 | 1000.00000 | -0.2404 | -0.6424 | 0.5600 | 0.2642 | 0.9697 | 1.3392 | |
| 184A1 | NM | Basal | Disulfiram | Proteasome | Proteasome | 12684.174 | uM | 14.63270 | 13.50790 | 0.1987 | 0.0386 | 1.0041 | 0.1179 | 0.9898 | 1.4645 | |
| 184A1 | NM | Basal | GSK923295 | CENPE | Kinesin | 9047.001 | uM | inf | inf | 0.0385 | 0.0385 | 0.0000 | 0.2510 | 0.5226 | 0.7701 | |
| 184A1 | NM | Basal | TCS 2312 | CHK1 | CHK | 12509.152 | uM | 0.52576 | 0.68654 | -0.6028 | -0.3929 | 2.1732 | 0.3972 | 0.9705 | 1.3755 | |
| 184A1 | NM | Basal | GSK923295 | CENPE | Kinesin | 10002.001 | uM | 8.47170 | 11.6240 | -0.9507 | -1.0000 | 3.4729 | 0.2407 | 0.9439 | 0.5372 | |
| 184A1 | NM | Basal | TCS PIM-1 1 | Pim kinase | PIM | 12509.135 | uM | 11.05020 | 2.4860 | 0.3652 | 0.3169 | 0.6733 | 0.2265 | 0.9787 | 1.3717 |