Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184A1 | NM | Basal | Geldanamycin | HSP90 | HSP90 | 10002.012 | uM | 0.00232 | 0.00278 | -0.4963 | -0.4694 | 3.6140 | 1.2014 | 0.9946 | 0.5807 | |
| 184B5 | NM | Basal | Imatinib | ABL/KIT/PDGFR | nRTK | 5896.091 | uM | 23.18150 | 34.00000 | -0.9493 | -0.9584 | 2.7948 | 0.4637 | 0.9940 | 1.4988 | |
| 184A1 | NM | Basal | PD173074 | FGFR1/3 | RTK | 5895.093 | uM | 8.46530 | 9.95550 | -0.0760 | -0.1823 | 1.9169 | 0.0959 | 0.9866 | 1.3259 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 10263.034 | uM | 0.02525 | 0.11148 | -1.0000 | -1.0000 | 0.7398 | 1.0785 | 0.9792 | 0.3750 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 7849.001 | uM | 0.00104 | 0.00115 | -0.9115 | -0.3518 | 5.0000 | 1.0464 | 0.8751 | 0.5308 | |
| 184A1 | NM | Basal | PD184352 | MEK | MAPK | 12509.155 | uM | 8.55920 | 48.2470 | 0.1172 | -1.0000 | 0.6353 | 0.1432 | 0.9509 | 1.3444 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 7848.001 | uM | 0.00690 | 0.01004 | -0.7963 | -0.4889 | 1.8144 | 0.9258 | 0.9490 | 0.4548 | |
| 184A1 | NM | Basal | Afatinib | EGFR/HER2 | ErbB | 12509.165 | uM | 0.02251 | 0.33740 | -0.9088 | -1.0000 | 0.4058 | 0.8284 | 0.9307 | 1.5022 | |
| 184A1 | NM | Basal | Cisplatin | DNA cross-linker | DNA cross-linker | 10002.021 | uM | 2.61470 | 4.77760 | -0.9719 | -0.9559 | 1.7730 | 0.6305 | 0.9959 | 0.7195 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5895.095 | uM | 0.40767 | 0.41810 | -0.0165 | -0.0219 | 1.6956 | 0.7104 | 0.9924 | 1.4629 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 10263.034 | uM | 1.76130 | 2.7730 | -0.5448 | -0.5665 | 1.6689 | 0.4269 | 0.9813 | 0.3750 | |
| HCC2185 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 7848.002 | uM | 0.00176 | 0.00217 | -0.0325 | -0.1015 | 0.8880 | 0.7481 | 0.9274 | 0.5588 | |
| HCC2185 | TNBC | Luminal | Etoposide | TOP2 | TOP | 7464.074 | uM | 6.93160 | 44.65820 | -0.5404 | -1.0000 | 0.5897 | 0.3827 | 0.9952 | 0.5504 | |
| HCC2185 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 7849.04 | uM | 0.01717 | 0.02311 | -0.8205 | -0.7965 | 3.2059 | 1.1738 | 0.9991 | 0.5448 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 7848.001 | uM | 0.23168 | 2.21180 | -0.7395 | -1.0000 | 0.4869 | 0.5192 | 0.9120 | 0.4548 | |
| 184A1 | NM | Basal | PS-1145 | IKK | NFKB | 5895.065 | uM | inf | inf | 1.0031 | 1.0031 | 0.0000 | -0.0389 | -4.6402 | 1.3748 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 7849.001 | uM | 0.52517 | 4.12770 | -0.6199 | -1.0000 | 0.5329 | 0.4275 | 0.9620 | 0.5308 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 9420.001 | uM | 0.03883 | 0.83363 | -0.8630 | -1.0000 | 0.3583 | 0.6662 | 0.8579 | 0.3332 | |
| 184A1 | NM | Basal | Purvalanol A | CDK1 | CDK | 5895.067 | uM | 51.18430 | 39.92310 | 0.3558 | 0.3553 | 4.9894 | 0.0457 | 0.9764 | 1.4053 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 9047.001 | uM | 0.83697 | 5.25260 | -0.4457 | -0.9735 | 0.5885 | 0.3812 | 0.9828 | 0.7701 | |
| HCC2185 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 7462.085 | uM | 0.01916 | 0.07622 | -1.0000 | -1.0000 | 0.7956 | 0.9867 | 0.9706 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Gemcitabine | DNA replication | DNA replication | 7849.011 | uM | 0.03116 | 0.02711 | -0.0746 | 0.1113 | 1.8071 | 0.5893 | 0.9120 | 0.5467 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 10263.001 | uM | 0.14569 | 3.45390 | -0.4750 | -1.0000 | 0.3470 | 0.5409 | 0.8338 | 0.3258 | |
| 184A1 | NM | Basal | SB-3CT | MMP2/9 | MMP | 12509.168 | uM | 433.25760 | 1000.00000 | 0.6180 | -0.2672 | 0.5118 | 0.0585 | 0.8869 | 1.3516 | |
| HCC2185 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 7848.016 | uM | 162.91990 | 51.17650 | 0.6991 | 0.2901 | 0.7496 | 0.0336 | 0.7573 | 0.4818 |