Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | AG1024 | IGF1R | RTK | 7535.066 | uM | 5.15860 | 4.60680 | 0.2165 | 0.2160 | 5.0000 | 0.1733 | 0.9238 | 0.7812 | |
| SUM229PE | TNBC | - | AG1024 | IGF1R | RTK | 7537.066 | uM | 26.08790 | 6.20780 | 0.4820 | 0.3992 | 1.1154 | 0.1176 | 0.9213 | 2.0549 | |
| SUM229PE | TNBC | - | Afatinib | EGFR/HER2 | ErbB | 11058.158 | uM | 1.76370 | 5.52960 | -0.8088 | -1.0000 | 0.9614 | 0.4777 | 0.9540 | 2.1018 | |
| SUM229PE | TNBC | - | AS-252424 | PI3K | PI3K | 11058.158 | uM | inf | 1.27320 | 0.4597 | 0.6173 | 1.6385 | 0.1628 | 0.6573 | 2.1018 | |
| SUM229PE | TNBC | - | AG1478 | EGFR | ErbB | 9860.019 | uM | inf | 0.66920 | 0.6943 | 0.6826 | 1.3958 | 0.1614 | 0.7691 | 1.6927 | |
| SUM229PE | TNBC | - | AG1478 | EGFR | ErbB | 7536.016 | uM | 7.57380 | 8.19850 | -0.4001 | -0.2432 | 5.0000 | 0.4156 | 0.8150 | 0.6413 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 7537.074 | uM | 0.02770 | 0.04580 | -0.7839 | -0.7561 | 1.8316 | 1.1238 | 0.9963 | 2.0080 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 7535.074 | uM | 0.75051 | 3.36660 | -0.9254 | -1.0000 | 0.7320 | 0.6555 | 0.9722 | 1.0507 | |
| SUM229PE | TNBC | - | Baicalein | Lipoxygenase | Metabolism | 7535.072 | uM | 50.49310 | 39.54220 | 0.3408 | 0.3400 | 4.6606 | 0.0824 | 0.9254 | 1.0923 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 7535.074 | uM | 0.75051 | 3.36660 | -0.9254 | -1.0000 | 0.7320 | 0.6555 | 0.9722 | 1.0507 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 7537.074 | uM | 0.02770 | 0.04580 | -0.7839 | -0.7561 | 1.8316 | 1.1238 | 0.9963 | 2.0080 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 14807.203 | uM | 0.00365 | 0.00535 | -0.7798 | -0.7104 | 2.3037 | 1.2491 | 0.9925 | 1.7148 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 14807.203 | uM | 0.00365 | 0.00535 | -0.7798 | -0.7104 | 2.3037 | 1.2491 | 0.9925 | 1.7148 | |
| SUM229PE | TNBC | - | Etoposide | TOP2 | TOP | 7537.074 | uM | 1.34020 | 3.84820 | -0.5228 | -0.6098 | 0.7559 | 0.5759 | 0.9969 | 2.0080 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 13062.174 | uM | inf | inf | 0.9527 | 0.9527 | 0.0000 | 0.0333 | 0.0263 | 1.6688 | |
| SUM229PE | TNBC | - | Chloroquine | 13009.177 | uM | 12.99640 | 13.93620 | -0.2084 | -0.2089 | 5.0000 | 0.2147 | 0.8774 | 1.2366 | |||
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 13062.177 | uM | 0.03738 | 0.04574 | -0.8823 | -0.8489 | 4.9175 | 0.9640 | 0.9994 | 1.7820 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 13009.177 | uM | 0.02778 | 0.03439 | -0.9703 | -0.9534 | 5.0000 | 1.0656 | 0.9991 | 1.2366 | |
| SUM229PE | TNBC | - | Bosutinib | Src | nRTK | 11058.145 | uM | 1.66230 | 3.36430 | -0.4219 | -0.4809 | 0.9559 | 0.4062 | 0.9975 | 2.2039 | |
| SUM229PE | TNBC | - | CGC-11047 | Polyamine analogue | 9860.125 | uM | 72.45260 | 605.28790 | -0.8188 | -1.0000 | 0.5175 | 0.4253 | 0.9106 | 1.6001 | ||
| SUM229PE | TNBC | - | Carboplatin | DNA cross-linker | DNA cross-linker | 9860.011 | uM | 56.67140 | 63.40440 | -0.2532 | -0.2359 | 3.4427 | 0.2517 | 0.9936 | 1.4618 | |
| SUM229PE | TNBC | - | Cetuximab | EGFR | ErbB | 9860.125 | uM | inf | inf | 0.8773 | 0.8773 | 0.0000 | 0.0289 | 0.1275 | 1.6001 | |
| SUM229PE | TNBC | - | Dichloroacetate | PDK | PDK | 13009.176 | uM | inf | inf | 0.9440 | 0.9440 | 0.0000 | 0.0235 | 0.4653 | 1.6112 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 9860.121 | uM | 7.0970 | 19.66470 | -0.6646 | -1.0000 | 1.0780 | 0.2568 | 0.9930 | 1.7546 | |
| SUM229PE | TNBC | - | Chloroquine | 13062.177 | uM | 18.15470 | 23.00330 | -0.1491 | -0.2937 | 1.9521 | 0.1662 | 0.8995 | 1.7820 |