Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | PS-1145 | IKK | NFKB | 7537.065 | uM | inf | inf | 0.9458 | 0.9458 | 0.0000 | 0.0214 | 0.0000 | 1.8673 | |
| SUM229PE | TNBC | - | PS-1145 | IKK | NFKB | 7535.065 | uM | inf | inf | 0.8601 | 0.8601 | 0.0000 | 0.0395 | 0.4816 | 0.8663 | |
| SUM229PE | TNBC | - | Purvalanol A | CDK1 | CDK | 7537.067 | uM | 15.44060 | 22.47980 | 0.0008 | -0.1830 | 0.8305 | 0.2246 | 0.9827 | 1.9773 | |
| SUM229PE | TNBC | - | Ribavirin | 15359.211 | uM | inf | inf | 0.9761 | 0.9761 | 0.0000 | -0.0092 | -0.0004 | 1.4356 | |||
| SUM229PE | TNBC | - | SB-3CT | MMP2/9 | MMP | 11058.144 | uM | inf | 24.86070 | 0.7399 | 0.7396 | 4.9787 | 0.0191 | 0.8029 | 2.1171 | |
| SUM229PE | TNBC | - | Selumetinib | MEK | MAPK | 11058.155 | uM | 0.12678 | 0.34222 | -0.2593 | -0.3136 | 0.4903 | 0.5118 | 0.9872 | 2.0706 | |
| SUM229PE | TNBC | - | Sigma A6730 | AKT | AKT | 11058.158 | uM | 13.91380 | 24.25360 | -0.7786 | -1.0000 | 1.9770 | 0.2430 | 0.9723 | 2.1018 | |
| SUM229PE | TNBC | - | Sirolimus | MTOR | MTOR | 7536.068 | uM | 1.64030 | 36.44280 | -0.5080 | -1.0000 | 0.3543 | 0.4649 | 0.6373 | 0.6416 | |
| SUM229PE | TNBC | - | Sirolimus | MTOR | MTOR | 7537.069 | uM | 12.9580 | 27.13880 | -0.1558 | -1.0000 | 1.4861 | 0.1864 | 0.9046 | 1.9773 | |
| SUM229PE | TNBC | - | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7537.084 | uM | inf | inf | 0.7245 | 0.7245 | 0.0000 | 0.1075 | 0.4618 | 1.8684 | |
| SUM229PE | TNBC | - | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7537.067 | uM | 4.64840 | 8.89610 | -0.8964 | -0.9530 | 1.6435 | 0.4847 | 0.9939 | 1.9773 | |
| SUM229PE | TNBC | - | Taxol | TUBB | TUBB | 9860.002 | uM | 0.01019 | 0.01060 | -0.1600 | -0.1090 | 5.0000 | 0.6820 | 0.9944 | 1.5734 | |
| SUM229PE | TNBC | - | Taxol | TUBB | TUBB | 13062.002 | uM | 0.01884 | 0.01879 | -0.0381 | 0.0024 | 1.9806 | 0.5656 | 0.9950 | 1.6470 | |
| SUM229PE | TNBC | - | Taxol | TUBB | TUBB | 13009.002 | uM | 0.01925 | 0.02034 | -0.0938 | -0.0708 | 2.3909 | 0.6076 | 0.9968 | 1.3417 | |
| SUM229PE | TNBC | - | TCS 2312 | CHK1 | CHK | 11058.152 | uM | 1.43460 | 1.3490 | 0.0432 | 0.0560 | 1.9332 | 0.2208 | 0.9955 | 2.0809 | |
| SUM229PE | TNBC | - | TCS PIM-1 1 | Pim kinase | PIM | 11058.135 | uM | 30.59770 | 24.63560 | 0.3144 | 0.3142 | 4.5665 | 0.1064 | 0.9924 | 2.1492 | |
| SUM229PE | TNBC | - | Temsirolimus | MTOR | MTOR | 11058.144 | uM | 21.79610 | 41.83750 | -0.7969 | -1.0000 | 1.6848 | 0.2681 | 0.9656 | 2.1171 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 7536.078 | uM | 0.04635 | 0.07005 | -0.3942 | -0.4389 | 1.5257 | 0.8485 | 0.9492 | 1.1676 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 9860.121 | uM | 0.08155 | 0.09854 | -0.1151 | -0.1662 | 1.5158 | 0.6512 | 0.9630 | 1.7546 | |
| SUM229PE | TNBC | - | Torkinib | 15359.211 | uM | 0.31876 | 0.27769 | 0.0625 | 0.0286 | 0.4271 | 0.4000 | 0.8823 | 1.4356 | |||
| SUM229PE | TNBC | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11058.15 | uM | 0.66944 | 7.31880 | -0.4038 | -1.0000 | 0.4593 | 0.3571 | 0.9590 | 2.2684 | |
| SUM229PE | TNBC | - | TPCA-1 | IKK | NFKB | 7535.1 | uM | 1.4270 | 1.85450 | -0.4419 | -0.3288 | 1.9288 | 0.4688 | 0.9791 | 0.8740 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 7536.05 | uM | 0.00737 | 0.00936 | -0.1214 | -0.0803 | 0.6249 | 0.6217 | 0.9373 | 0.9494 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 9860.012 | uM | 0.00679 | 0.01303 | -0.2937 | -0.2993 | 0.7194 | 0.7184 | 0.9957 | 1.7144 | |
| SUM229PE | TNBC | - | Trichostatin A | HDAC | HDAC | 7537.065 | uM | 12.70040 | 19.70280 | -0.8200 | -0.7699 | 2.1225 | 0.7700 | 0.9975 | 1.8673 |