Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9035.001 | uM | 0.02298 | 0.02665 | -0.0875 | -0.2211 | 2.4716 | 0.6936 | 0.9681 | 2.4291 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 7793.001 | uM | 0.02405 | 0.02845 | -0.7415 | -0.6582 | 5.0000 | 0.9064 | 0.9803 | 1.1508 | |
| AU565 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 5900.088 | uM | inf | 7.75810 | 0.6475 | 0.6473 | 4.9899 | 0.0383 | 0.9887 | 2.7830 | |
| AU565 | HER2amp | Luminal | Ibandronate | FDPS | 10880.143 | uM | 190.49250 | 139.95740 | 0.2035 | 0.1860 | 1.5087 | 0.1480 | 0.9763 | 1.6077 | ||
| AU565 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 10880.151 | uM | 1.03060 | 0.48809 | 0.2691 | 0.2426 | 0.8883 | 0.2612 | 0.9893 | 1.8509 | |
| AU565 | HER2amp | Luminal | IKK16 | IKK | NFKB | 5900.093 | uM | 3.11010 | 4.89820 | -0.7771 | -0.7902 | 2.0869 | 0.3658 | 0.9980 | 2.3084 | |
| AU565 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 5901.091 | uM | 19.04840 | 28.45990 | -0.8741 | -0.8850 | 2.5375 | 0.4460 | 0.9984 | 1.9229 | |
| AU565 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 5900.092 | uM | 25.17290 | 35.4570 | -0.7508 | -0.7538 | 2.6838 | 0.3679 | 0.9995 | 2.6334 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 5900.067 | uM | 0.02287 | 0.02721 | -0.8045 | -0.5292 | 4.1590 | 0.8231 | 0.9793 | 2.4324 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 5901.067 | uM | 0.01802 | 0.02217 | -0.9025 | -0.7242 | 4.3172 | 0.9599 | 0.9934 | 1.8762 | |
| AU565 | HER2amp | Luminal | Everolimus | MTOR | MTOR | 10880.156 | uM | 0.57383 | 7.51240 | -0.8788 | -1.0000 | 0.4272 | 0.4508 | 0.8269 | 1.5288 | |
| BT-474 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7797.016 | uM | 0.25036 | 0.02995 | 0.2168 | 0.2584 | 0.3426 | 0.4729 | 0.9352 | 0.5155 | ||
| BT-474 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9163.037 | uM | 0.02296 | 0.02797 | -0.9651 | -0.8419 | 4.9994 | 1.1656 | 0.9949 | 0.5258 | |
| AU565 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 5901.074 | uM | 0.51180 | 1.05610 | -0.7095 | -0.6601 | 1.1618 | 0.7400 | 0.9963 | 1.8718 | |
| AU565 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 5900.074 | uM | 0.98749 | 1.56220 | -0.5584 | -0.4906 | 1.4905 | 0.6041 | 0.9955 | 2.4189 | |
| BT-474 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5906.067 | uM | 12.96240 | 16.14770 | -0.9982 | -1.0000 | 5.0000 | 0.3347 | 0.9970 | 0.6838 | |
| AU565 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 5901.091 | uM | 8.69220 | 14.69410 | -0.3289 | -0.5059 | 1.3314 | 0.1854 | 0.9974 | 1.9229 | |
| AU565 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 5900.092 | uM | 22.11190 | 37.99340 | 0.1765 | -0.8772 | 1.8718 | 0.0574 | 0.9942 | 2.6334 | |
| BT-474 | HER2amp | Luminal | 2-deoxyglucose | 13125.177 | uM | inf | inf | -0.1564 | -0.1564 | 0.0000 | 0.4335 | 0.4985 | 0.8991 | |||
| BT-474 | HER2amp | Luminal | TAPI-0 | TACE/Collagenase | 5905.096 | uM | 63.96990 | 112.68570 | 0.6808 | -0.3704 | 0.9791 | 0.0316 | 0.8092 | 0.9091 | ||
| BT-474 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9157.002 | uM | 0.01170 | 0.01401 | -0.2154 | -0.1440 | 1.4006 | 0.6817 | 0.9924 | 0.9306 | |
| AU565 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 7793.035 | uM | 0.12215 | 0.18964 | -0.9918 | -0.9217 | 2.3757 | 1.0184 | 0.9961 | 1.2119 | |
| AU565 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 7794.017 | uM | 0.13634 | 0.36050 | -0.9484 | -0.8758 | 1.0409 | 0.8678 | 0.9898 | 1.9851 | |
| BT-474 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5905.085 | uM | 25.84930 | 58.21470 | -0.9937 | -1.0000 | 1.3532 | 0.3254 | 0.9707 | 0.8847 | |
| AU565 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 9035.017 | uM | 0.15993 | 0.19598 | -0.8793 | -0.2970 | 2.2943 | 0.7775 | 0.5906 | 2.2905 |