Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Nelfinavir | 13030.174 | uM | inf | inf | 0.9367 | 0.9367 | 0.0000 | 0.0424 | 0.0713 | 0.8615 | |||
| UACC-812 | HER2amp | Luminal | Methylglyoxal | 13078.184 | uM | 430.98580 | 1000.00000 | -0.9987 | -0.7092 | 1.0492 | 0.5284 | 0.8894 | 0.6800 | |||
| 184B5 | NM | Basal | 2-deoxyglucose | 12979.177 | uM | 559.39550 | 583.2410 | -0.1158 | -0.1161 | 5.0000 | 0.2148 | 0.7107 | 0.5647 | |||
| T47D | HR+ | Luminal | Methylglyoxal | 13623.184 | uM | 575.5230 | 599.38190 | -0.7988 | -0.1126 | 5.0000 | 0.5014 | 0.5757 | 1.1220 | |||
| HCC70 | TNBC | Basal A | Methylglyoxal | 13607.184 | uM | inf | inf | -0.7097 | -0.7097 | 0.0000 | 0.5913 | 0.5266 | 0.8612 | |||
| SUM225CWN | HER2amp | Basal A | Ribavirin | 15403.211 | uM | inf | inf | 0.4799 | 0.4799 | 0.0000 | 0.2473 | 0.3950 | 0.7553 | |||
| 21NT | HER2amp | - | Mebendazole | 13575.174 | uM | 0.70544 | 0.60467 | 0.2760 | 0.2687 | 5.0000 | 0.2944 | 0.9408 | 1.5845 | |||
| SUM52PE | HR+ | Luminal | Nelfinavir | 13570.174 | uM | inf | inf | 0.3681 | 0.3681 | 0.0000 | 0.1153 | 0.4883 | 0.5197 | |||
| HCC1143 | TNBC | Basal A | Mebendazole | 13099.174 | uM | 0.87433 | 2.73210 | -0.2007 | -0.3902 | 0.5063 | 0.3895 | 0.9656 | 0.9441 | |||
| SUM229PE | TNBC | - | Mebendazole | 13062.174 | uM | 21.85180 | 649.20950 | 0.2977 | -1.0000 | 0.3239 | 0.1848 | 0.9092 | 1.6688 | |||
| 21NT | HER2amp | - | Methylglyoxal | 13653.184 | uM | 371.60 | 1000.00000 | -0.9322 | -0.8591 | 1.0101 | 0.5941 | 0.9376 | 1.5871 | |||
| SUM229PE | TNBC | - | Nelfinavir | 13009.174 | uM | 6.26470 | 9.98760 | -0.8378 | -0.9544 | 2.2893 | 0.2181 | 0.9953 | 1.4104 | |||
| HCC1954 | HER2amp | Basal A | Mebendazole | 13546.174 | uM | 0.14538 | 0.29445 | -0.3581 | -0.3118 | 0.6867 | 0.5674 | 0.9294 | 1.2035 | |||
| SUM229PE | TNBC | - | Chloroquine | 13009.177 | uM | 12.99640 | 13.93620 | -0.2084 | -0.2089 | 5.0000 | 0.2147 | 0.8774 | 1.2366 | |||
| MCF 10F | NM | - | Ribavirin | 15393.211 | uM | inf | inf | 0.8354 | 0.8354 | 0.0000 | 0.0133 | 0.5287 | 1.6449 | |||
| SUM52PE | HR+ | Luminal | Nelfinavir | 12969.174 | uM | 8.40510 | 18.55740 | -0.4010 | -1.0000 | 1.3871 | 0.2195 | 0.9278 | 1.1194 | |||
| HCC70 | TNBC | Basal A | Mebendazole | 12714.174 | uM | 0.11165 | 0.17592 | -0.9403 | -0.8934 | 2.2542 | 1.0180 | 0.9090 | 0.3306 | |||
| ZR75B | HR+ | Luminal | Methylglyoxal | 13525.184 | uM | 609.46450 | 1000.00000 | -0.8388 | -0.3641 | 1.1049 | 0.3628 | 0.8593 | 1.7478 | |||
| Hs 578T | TNBC | Basal B | Nelfinavir | 12622.174 | uM | 9.16330 | 14.61050 | -0.7502 | -1.0000 | 2.3548 | 0.1522 | 0.9989 | 2.4358 | |||
| T47DKBLUC | Unknown | Unknown | Torkinib | 15360.211 | uM | 0.00023 | 0.00037 | -0.1763 | -0.1097 | 0.4213 | 0.9138 | 0.9795 | 0.8772 | |||
| HCC1954 | HER2amp | Basal A | Methylglyoxal | 13631.184 | uM | inf | inf | -0.9647 | -0.9647 | 0.0000 | 0.6967 | 0.4015 | 1.3577 | |||
| SUM229PE | TNBC | - | 2-deoxyglucose | 13009.177 | uM | 737.68510 | 1000.00000 | 0.0596 | -0.1957 | 1.0856 | 0.1991 | 0.7659 | 1.2366 | |||
| MCF12A | NM | Basal B | Pertuzumab | 7489.102 | mg/ml | inf | 125.00000 | 0.8728 | 0.5007 | 0.2455 | 0.0447 | 0.7417 | 2.4234 | |||
| ZR-75-1 | HR+ | Luminal | Ribavirin | 15346.211 | uM | inf | inf | 0.7643 | 0.7643 | 0.0000 | 0.0402 | -0.0208 | 0.6395 | |||
| BT-483 | HR+ | Luminal | Mebendazole | 13130.174 | uM | 2.05160 | 1.15580 | 0.2836 | 0.0818 | 0.3113 | 0.3396 | 0.8145 | 0.5126 |