Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | 5-DFUR | TYMS | TYMS | 12566.143 | uM | 303.43380 | 999.99910 | 0.1514 | -0.2734 | 0.3658 | 0.2766 | 0.9906 | 1.6413 | |
| CAMA-1 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 12070.143 | uM | 180.68920 | 330.87140 | -0.0282 | -0.2049 | 0.5677 | 0.2807 | 0.9638 | 0.9561 | |
| CAMA-1 | HR+ | Luminal | 5-FU | TYMS | TYMS | 9210.131 | uM | 201.89680 | 1000.00000 | -0.4736 | -0.7823 | 0.5886 | 0.4803 | 0.9489 | 0.9004 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5911.094 | uM | 0.25033 | 0.05775 | 0.4743 | 0.4915 | 2.7768 | 0.4432 | 0.8140 | 1.0146 | |
| HBL-100 | Unknown | Unknown | 5-FU | TYMS | TYMS | 7808.017 | uM | 153.52750 | 267.86840 | -0.0890 | -0.1730 | 0.5339 | 0.3993 | 0.9832 | 2.4168 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 9047.017 | uM | 48.1950 | 95.9710 | -0.8459 | -0.8556 | 1.4480 | 0.8094 | 0.9747 | 0.8440 | |
| 600MPE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5899.094 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0167 | -0.1754 | 1.0334 | |
| 600MPE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5898.095 | uM | inf | inf | 0.3076 | 0.3076 | 0.0000 | 0.6877 | 0.0000 | 0.6975 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5895.095 | uM | 0.40767 | 0.41810 | -0.0165 | -0.0219 | 1.6956 | 0.7104 | 0.9924 | 1.4629 | |
| AU565 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 10880.143 | uM | 16.77060 | 49.34150 | -0.1493 | -0.2316 | 0.3527 | 0.4585 | 0.8930 | 1.6077 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7794.017 | uM | 3.63770 | 2.00040 | 0.0921 | 0.3519 | 2.0349 | 0.4369 | 0.8863 | 1.9851 | |
| BT-20 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5902.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.0245 | |
| BT-20 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5904.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.6537 | |
| 600MPE | HR+ | Luminal | 5-FU | TYMS | TYMS | 9118.017 | uM | 78.35630 | 305.35030 | -0.9327 | -1.0000 | 0.8077 | 0.6926 | 0.9801 | 1.0401 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 9035.017 | uM | 234.20810 | 255.89090 | 0.0352 | -0.0320 | 0.6997 | 0.3489 | 0.9930 | 2.2905 | |
| 184B5 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5897.095 | uM | 0.52125 | 0.66097 | -0.3237 | -0.3105 | 2.0341 | 0.8593 | 0.9969 | 1.2197 | |
| 184B5 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5896.095 | uM | 0.24202 | 0.32119 | -0.2838 | -0.2743 | 1.5454 | 0.9106 | 0.9931 | 1.5532 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5894.095 | uM | 53.72510 | 62.72890 | -0.1792 | -0.0920 | 1.0901 | 0.3508 | 0.940 | 1.7133 | |
| BT-474 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5905.095 | uM | inf | inf | 0.9541 | 0.9541 | 0.0000 | 0.0237 | 0.0563 | 0.9590 | |
| 600MPE | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 12224.143 | uM | 0.98003 | 1.61660 | -0.3636 | -0.1428 | 0.5018 | 0.6782 | 0.9151 | 0.8349 | |
| BT-483 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 10696.143 | uM | 63.52740 | 851.88480 | -0.3979 | -1.0000 | 0.4232 | 0.4208 | 0.9738 | 0.5188 | |
| 184A1 | NM | Basal | 5-DFUR | TYMS | TYMS | 12509.143 | uM | 228.63720 | 1000.00000 | -0.2404 | -0.6424 | 0.5600 | 0.2642 | 0.9697 | 1.3392 | |
| AU565 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5901.095 | uM | inf | 0.0510 | 0.5951 | 0.6004 | 0.9976 | 0.3405 | 0.8985 | 1.9104 | |
| HCC1143 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7430.095 | uM | inf | inf | 0.8459 | 0.8459 | 0.0000 | 0.1262 | 0.4872 | 1.9390 | |
| HCC1143 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7810.017 | uM | 79.51050 | 198.63970 | -0.3272 | -0.3499 | 0.5794 | 0.4638 | 0.9680 | 0.8986 |