Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10265.021 | uM | inf | inf | -0.7752 | -0.7752 | 0.0000 | 0.3146 | 0.5744 | 0.3095 | |
| MDA-MB-134-VI | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10265.021 | uM | 248.53190 | 343.89760 | -0.9993 | -1.0000 | 3.3827 | 0.2219 | 0.9702 | 0.3095 | |
| SUM185PE | TNBC | Luminal | Valproic acid | HDAC | HDAC | 12269.143 | uM | 831.78640 | 1000.00000 | -0.9728 | -0.7558 | 5.0000 | 0.3220 | 0.9529 | 0.3088 | |
| SUM185PE | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 12269.143 | uM | 273.61780 | 1000.00000 | -0.7007 | -0.8839 | 0.7855 | 0.2443 | 0.8106 | 0.3088 | |
| SUM185PE | TNBC | Luminal | Ibandronate | FDPS | 12269.143 | uM | 160.42990 | 196.12130 | -0.8638 | -0.8651 | 5.0000 | 0.4406 | 0.8751 | 0.3088 | ||
| HCC1187 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7811.044 | uM | 11.65150 | 16.05880 | -1.0000 | -0.9995 | 3.4233 | 0.3459 | 0.9975 | 0.3073 | ||
| HCC1187 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7811.044 | uM | inf | inf | 0.9811 | 0.9811 | 0.0000 | 0.0159 | -0.0256 | 0.3073 | |
| HCC1187 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 7811.044 | uM | 24.92130 | 30.93870 | -0.1669 | -0.9744 | 5.0000 | 0.0514 | 0.9684 | 0.3073 | |
| HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7844.001 | uM | inf | inf | -0.9997 | -0.9997 | 0.0000 | 0.8273 | 0.4411 | 0.3060 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 7844.001 | uM | 0.03286 | 0.04068 | -0.8899 | -0.5598 | 3.5183 | 0.9169 | 0.8332 | 0.3060 | |
| HCC202 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 7844.001 | uM | 0.06390 | 2.53280 | -0.7770 | -1.0000 | 0.2986 | 0.6191 | 0.6516 | 0.3060 | |
| UACC-812 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10151.021 | uM | 3.19650 | 5.62320 | -1.0000 | -1.0000 | 1.9450 | 0.6339 | 0.9669 | 0.3048 | |
| UACC-812 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10151.021 | uM | 7.84270 | 16.49440 | -0.9996 | -0.9978 | 1.4758 | 0.6545 | 0.9947 | 0.3048 | |
| UACC-812 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10151.021 | uM | 0.21571 | 0.96877 | -1.0000 | -1.0000 | 0.7314 | 1.0052 | 0.9765 | 0.3048 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9913.001 | uM | 12.93750 | 16.11690 | -0.9831 | -1.0000 | 4.9996 | 0.0837 | 0.9941 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9913.001 | uM | 25.9350 | 31.80570 | -0.0515 | -0.8870 | 5.0000 | 0.0501 | 0.9461 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9913.001 | uM | 0.01022 | 0.01151 | -0.3520 | -0.4040 | 4.9494 | 0.9230 | 0.8876 | 0.3047 | |
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 10996.143 | uM | 124.03170 | 741.86030 | -0.5992 | -1.0000 | 0.6142 | 0.4500 | 0.8811 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Ibandronate | FDPS | 10996.143 | uM | 5.57070 | 12.55950 | -0.8193 | -0.8147 | 1.1892 | 0.6554 | 0.9960 | 0.3034 | ||
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 10996.143 | uM | 442.73320 | 1000.00000 | -1.0000 | -1.0000 | 1.3483 | 0.4840 | 0.9488 | 0.3034 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10816.15 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.3031 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10816.15 | uM | 21.64110 | 26.9580 | -0.4840 | -0.9997 | 5.0000 | 0.0458 | 0.9904 | 0.3031 | |
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 10816.15 | uM | 1.03120 | 1.75740 | -0.9598 | -0.9331 | 1.9753 | 0.3994 | 0.9955 | 0.3031 |