Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | Celecoxib | COX2 | COX | 10578.136 | uM | inf | inf | 0.9640 | 0.9640 | 0.0000 | 0.0221 | 0.0000 | 1.5577 | |
| MDA-MB-415 | HR+ | Luminal | PD 98059 | MEK | MAPK | 10938.152 | uM | inf | inf | 0.6339 | 0.6339 | 0.0000 | 0.4272 | 0.0000 | 0.9498 | |
| HCC70 | TNBC | Basal A | Disulfiram | Proteasome | Proteasome | 12714.174 | uM | inf | inf | 1.0210 | 1.0210 | 0.0000 | 0.2086 | 0.0000 | 0.3306 | |
| HCC1428 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7443.098 | uM | inf | inf | 0.9399 | 0.9399 | 0.0000 | 0.0425 | 0.0000 | 0.9189 | |
| MX1 | Unknown | Unknown | FTase Inhibitor I | Ftase | MAPK | 10874.154 | uM | inf | inf | 0.9041 | 0.9041 | 0.0000 | 0.0469 | 0.0000 | 0.7639 | |
| MCF7 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 10997.154 | uM | inf | inf | 0.9609 | 0.9609 | 0.0000 | 0.0407 | 0.0000 | 1.0978 | |
| MDA-MB-175-VII | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 10642.142 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0208 | 0.0000 | 0.5006 | |
| BT-20 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 11854.154 | uM | inf | inf | 0.8747 | 0.8747 | 0.0000 | 0.1104 | 0.0000 | 1.3146 | |
| HCC70 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 7470.085 | uM | inf | inf | 0.6898 | 0.6898 | 0.0000 | 0.2374 | 0.0000 | 0.9880 | |
| MDA-MB-134-VI | HR+ | Luminal | Nilotinib | ABL | nRTK | 10998.145 | uM | inf | inf | 0.8805 | 0.8805 | 0.0000 | 0.1761 | 0.0000 | 0.9403 | |
| HCC2185 | TNBC | Luminal | PD184352 | MEK | MAPK | 10996.155 | uM | inf | inf | 0.8210 | 0.8210 | 0.0000 | 0.1837 | 0.0000 | 0.6934 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 10874.149 | uM | inf | inf | 0.9293 | 0.9293 | 0.0000 | 0.0534 | 0.0000 | 0.8239 | |
| MDA-MB-175-VII | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 12126.16 | uM | inf | inf | 0.7655 | 0.7655 | 0.0000 | 0.2418 | 0.0000 | 0.6930 | ||
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7457.094 | uM | inf | inf | 0.8077 | 0.8077 | 0.0000 | 0.2414 | 0.0000 | 1.8462 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 5903.084 | uM | inf | inf | 1.0102 | 1.0102 | 0.0000 | 0.0105 | 0.0000 | 1.2088 | |
| HCC2185 | TNBC | Luminal | FTase Inhibitor I | Ftase | MAPK | 10996.154 | uM | inf | inf | 0.7281 | 0.7281 | 0.0000 | 0.2218 | 0.0000 | 0.5230 | |
| HCC1569 | HER2amp | Basal A | Nilotinib | ABL | nRTK | 10872.145 | uM | inf | inf | 1.0423 | 1.0423 | 0.0000 | 0.0067 | 0.0000 | 1.6308 | |
| HCC1569 | HER2amp | Basal A | Nilotinib | ABL | nRTK | 12523.17 | uM | inf | inf | 0.8636 | 0.8636 | 0.0000 | 0.0444 | 0.0000 | 0.8990 | |
| CAMA-1 | HR+ | Luminal | Celecoxib | COX2 | COX | 10473.136 | uM | inf | inf | 0.9467 | 0.9467 | 0.0000 | 0.0581 | 0.0000 | 1.3186 | |
| HCC1569 | HER2amp | Basal A | PD184352 | MEK | MAPK | 10872.155 | uM | inf | inf | 0.9297 | 0.9297 | 0.0000 | 0.0301 | 0.0000 | 1.5288 | |
| HCC1569 | HER2amp | Basal A | PD184352 | MEK | MAPK | 10872.155 | uM | inf | inf | 0.9297 | 0.9297 | 0.0000 | 0.0301 | 0.0000 | 1.5288 | |
| HCC2185 | TNBC | Luminal | PD184352 | MEK | MAPK | 10996.155 | uM | inf | inf | 0.8210 | 0.8210 | 0.0000 | 0.1837 | 0.0000 | 0.6934 | |
| HCC1806 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 9376.049 | uM | inf | inf | 0.9525 | 0.9525 | 0.0000 | 0.0225 | 0.0000 | 1.9229 | |
| 600MPE | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 12224.144 | uM | inf | inf | 0.9302 | 0.9302 | 0.0000 | 0.0839 | 0.0000 | 1.0210 | |
| MDA-MB-134-VI | HR+ | Luminal | Sulindac sulfide | COX1/2 | COX | 10519.136 | uM | inf | inf | 0.9265 | 0.9265 | 0.0000 | 0.0200 | 0.0000 | 1.1406 |