Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 12084.154 | uM | inf | inf | 0.7715 | 0.7715 | 0.0000 | 0.1395 | -0.0309 | 1.2963 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 12178.16 | uM | inf | inf | 0.5577 | 0.5577 | 0.0000 | 0.3142 | 0.4077 | 0.7392 | |
| HCC1143 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 12112.154 | uM | inf | inf | 0.8713 | 0.8713 | 0.0000 | 0.0797 | -0.0472 | 1.8321 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7474.09 | uM | inf | inf | 0.9564 | 0.9564 | 0.0000 | -0.0195 | -0.0520 | 2.4405 | |
| HCC1954 | HER2amp | Basal A | Nilotinib | ABL | nRTK | 11055.145 | uM | inf | inf | 0.9791 | 0.9791 | 0.0000 | -0.0257 | -0.8188 | 1.7616 | |
| MDA-MB-415 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9664.049 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.7193 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14191.189 | uM | inf | inf | -0.1161 | -0.1161 | 0.0000 | 0.5482 | 0.5418 | 2.9704 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 12098.161 | uM | inf | inf | 0.4834 | 0.4834 | 0.0000 | 0.1703 | 0.2896 | 1.4196 | |
| HCC1954 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 11055.072 | uM | inf | inf | 0.8354 | 0.8354 | 0.0000 | 0.0723 | 0.1965 | 1.7997 | |
| MDA-MB-361 | HER2amp | Luminal | Ro 32-0432 | PKC | PKC | 10643.142 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0284 | -0.7438 | 0.5166 | |
| 184A1 | NM | Basal | Vinorelbine | TUBB | TUBB | 7787.018 | uM | inf | inf | -0.9963 | -0.9963 | 0.0000 | 0.4831 | 0.4499 | 0.3791 | |
| SUM225CWN | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 10579.138 | uM | inf | inf | 0.9224 | 0.9224 | 0.0000 | 0.0099 | 0.1840 | 0.9860 | ||
| MDA-MB-175-VII | HR+ | Luminal | Etoposide | TOP2 | TOP | 7500.074 | uM | inf | inf | -0.3130 | -0.3130 | 0.0000 | 0.3186 | 0.5305 | 0.5279 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14191.189 | uM | inf | inf | -0.1161 | -0.1161 | 0.0000 | 0.5482 | 0.5418 | 2.9704 | |
| MCF 10F | NM | - | 5-FU | TYMS | TYMS | 9566.017 | uM | inf | inf | -0.5228 | -0.5228 | 0.0000 | 0.9440 | 0.5049 | 2.1734 | |
| HCC1395 | TNBC | Basal B | GM6001 | MMP | MMP | 7436.096 | uM | inf | inf | 0.8287 | 0.8287 | 0.0000 | 0.0732 | -0.0129 | 1.3979 | |
| MDA-MB-134-VI | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7494.09 | uM | inf | inf | 0.5852 | 0.5852 | 0.0000 | 0.1382 | 0.2867 | 1.0823 | |
| HCC1954 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 7454.072 | uM | inf | inf | 0.7579 | 0.7579 | 0.0000 | 0.1432 | -0.0206 | 1.3300 | |
| SUM225CWN | HER2amp | Basal A | GW843682X | PLK | PLK | 10579.139 | uM | inf | inf | 0.8101 | 0.8101 | 0.0000 | 0.0896 | 0.0081 | 1.1260 | |
| BT-483 | HR+ | Luminal | AG1024 | IGF1R | RTK | 5908.066 | uM | inf | inf | 0.0534 | 0.0534 | 0.0000 | 0.3542 | 0.4565 | 0.4546 | |
| 184A1 | NM | Basal | Sirolimus | MTOR | MTOR | 7787.068 | uM | inf | inf | -0.2794 | -0.2794 | 0.0000 | 0.5821 | 0.4995 | 0.9562 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 10579.139 | uM | inf | inf | 0.6972 | 0.6972 | 0.0000 | 0.1100 | -0.0164 | 1.1260 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 12098.157 | uM | inf | inf | 0.7855 | 0.7855 | 0.0000 | 0.0460 | 0.3066 | 1.3067 |