Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-436 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7900.018 | uM | inf | inf | 0.5694 | 0.5694 | 0.0000 | 0.2033 | -0.0548 | 0.8304 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 10938.155 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.5336 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 12056.157 | uM | inf | inf | 0.8491 | 0.8491 | 0.0000 | 0.0630 | 0.0552 | 0.9748 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 12291.157 | uM | inf | inf | 0.6757 | 0.6757 | 0.0000 | 0.1553 | 0.1959 | 0.5161 | |
| HCC3153 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 7466.088 | uM | inf | inf | 0.7503 | 0.7503 | 0.0000 | 0.0866 | 0.2768 | 0.9180 | |
| MDA-MB-361 | HER2amp | Luminal | GM6001 | MMP | MMP | 7506.096 | uM | inf | inf | 0.9793 | 0.9793 | 0.0000 | 0.0173 | -0.0292 | 1.0303 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 7463.084 | uM | inf | inf | 0.8941 | 0.8941 | 0.0000 | 0.0497 | 0.0064 | 0.7560 | |
| MDA-MB-157 | TNBC | Basal B | AG1024 | IGF1R | RTK | 7498.066 | uM | inf | inf | 0.9884 | 0.9884 | 0.0000 | -0.0181 | -0.3947 | 1.0752 | |
| SUM159PT | TNBC | Basal B | GM6001 | MMP | MMP | 7531.096 | uM | inf | inf | 0.9199 | 0.9199 | 0.0000 | 0.0349 | 0.0835 | 3.5504 | |
| CAMA-1 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10755.148 | uM | inf | inf | 0.5279 | 0.5279 | 0.0000 | 0.2240 | 0.4039 | 0.6379 | |
| HCC1143 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7810.006 | uM | inf | inf | 0.8576 | 0.8576 | 0.0000 | 0.0064 | 0.5591 | 0.9730 | |
| HCC1187 | TNBC | Basal A | Celecoxib | COX2 | COX | 10518.136 | uM | inf | inf | 0.9091 | 0.9091 | 0.0000 | 0.0220 | 0.1805 | 1.2490 | |
| HCC1187 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7811.018 | uM | inf | inf | 0.6946 | 0.6946 | 0.0000 | 0.1308 | -0.0060 | 0.4694 | |
| HCC1187 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7812.042 | uM | inf | inf | 0.5614 | 0.5614 | 0.0000 | 0.0267 | 0.3674 | 0.9722 | |
| BT-474 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 12178.144 | uM | inf | inf | 0.6802 | 0.6802 | 0.0000 | 0.1793 | -0.0043 | 0.7891 | |
| BT-474 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 12056.144 | uM | inf | inf | 0.8442 | 0.8442 | 0.0000 | 0.0965 | 0.2228 | 0.9738 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9146.122 | uM | inf | inf | 0.9694 | 0.9694 | 0.0000 | -0.0404 | -1.9847 | 1.3408 | |
| HCC1806 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7451.095 | uM | inf | inf | 0.7452 | 0.7452 | 0.0000 | 0.2906 | 0.3518 | 2.2028 | |
| HCC1954 | HER2amp | Basal A | TPCA-1 | IKK | NFKB | 7454.093 | uM | inf | inf | 0.7670 | 0.7670 | 0.0000 | 0.2123 | -0.1144 | 1.3347 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 12291.166 | uM | inf | inf | 0.1392 | 0.1392 | 0.0000 | 0.2732 | 0.4769 | 0.5962 | |
| 184B5 | NM | Basal | Sirolimus | MTOR | MTOR | 7789.068 | uM | inf | inf | -0.9304 | -0.9304 | 0.0000 | 1.0723 | 0.4470 | 0.3219 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7793.018 | uM | inf | inf | 0.9318 | 0.9318 | 0.0000 | 0.0067 | 0.3477 | 1.3186 | |
| HCC1187 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 10753.146 | uM | inf | inf | 0.7845 | 0.7845 | 0.0000 | 0.1084 | 0.4052 | 1.4503 | |
| HCC1187 | TNBC | Basal A | Dichloroacetate | PDK | PDK | 13726.176 | uM | inf | inf | 0.6786 | 0.6786 | 0.0000 | 0.3517 | -0.3654 | 0.4071 | |
| HCC1143 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7809.018 | uM | inf | inf | 0.9659 | 0.9659 | 0.0000 | -0.0257 | -0.2331 | 1.6742 |