Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 12291.165 | uM | 0.00084 | 0.00487 | -0.9997 | -1.0000 | 0.6233 | 1.4610 | 0.9623 | 0.5602 | |
| UACC-812 | HER2amp | Luminal | Torkinib | 15404.211 | uM | 0.00005 | 0.00056 | -0.8141 | -0.8007 | 0.3960 | 1.4387 | 0.9967 | 0.5754 | |||
| MDA-MB-468 | TNBC | Basal A | Taxol | TUBB | TUBB | 7905.002 | uM | 0.00606 | 0.00753 | -0.9966 | -0.9878 | 5.0000 | 1.4358 | 0.8612 | 0.4198 | |
| HCC70 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 7470.074 | uM | 0.01174 | 0.01593 | -0.9855 | -0.9872 | 3.5670 | 1.4267 | 0.9982 | 0.9618 | |
| HCC70 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 7470.074 | uM | 0.01174 | 0.01593 | -0.9855 | -0.9872 | 3.5670 | 1.4267 | 0.9982 | 0.9618 | |
| CAMA-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 5912.095 | uM | 0.00065 | 0.00095 | -0.9867 | -0.7402 | 2.3688 | 1.4206 | 0.9535 | 0.9981 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14924.203 | uM | 0.00405 | 0.00616 | -0.9568 | -0.9655 | 2.5587 | 1.4202 | 0.9993 | 1.0024 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14924.203 | uM | 0.00405 | 0.00616 | -0.9568 | -0.9655 | 2.5587 | 1.4202 | 0.9993 | 1.0024 | |
| HCC3153 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 14906.203 | uM | 0.00480 | 0.00655 | -0.9875 | -0.9877 | 3.5203 | 1.4194 | 0.9990 | 0.7818 | |
| HCC3153 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 14906.203 | uM | 0.00480 | 0.00655 | -0.9875 | -0.9877 | 3.5203 | 1.4194 | 0.9990 | 0.7818 | |
| SUM185PE | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 15332.203 | uM | 0.00634 | 0.00850 | -0.9967 | -0.9967 | 3.7282 | 1.4136 | 0.9927 | 0.7106 | |
| SUM185PE | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 15332.203 | uM | 0.00634 | 0.00850 | -0.9967 | -0.9967 | 3.7282 | 1.4136 | 0.9927 | 0.7106 | |
| HCC2185 | TNBC | Luminal | Torkinib | 15306.211 | uM | 0.00017 | 0.00130 | -0.8220 | -0.8191 | 0.4777 | 1.4061 | 0.9962 | 0.4935 | |||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 7835.018 | uM | 0.10893 | 0.35289 | -1.0000 | -0.9136 | 0.8841 | 1.3946 | 0.9756 | 0.5326 | ||
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 10472.087 | uM | 0.00138 | 0.00445 | -0.9999 | -1.0000 | 0.9369 | 1.3934 | 0.9945 | 0.5566 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 7906.012 | uM | 0.00062 | 0.00321 | -0.8093 | -0.7684 | 0.5677 | 1.3829 | 0.6159 | 0.4916 | |
| HCC1187 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 7432.074 | uM | 0.01535 | 0.02166 | -0.9993 | -0.9985 | 3.1914 | 1.3750 | 0.9993 | 0.8598 | |
| HCC1187 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 7432.074 | uM | 0.01535 | 0.02166 | -0.9993 | -0.9985 | 3.1914 | 1.3750 | 0.9993 | 0.8598 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 15340.203 | uM | 0.00373 | 0.00642 | -0.9095 | -0.9143 | 1.9126 | 1.3715 | 0.9998 | 1.4449 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 15340.203 | uM | 0.00373 | 0.00642 | -0.9095 | -0.9143 | 1.9126 | 1.3715 | 0.9998 | 1.4449 | |
| AU565 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 14817.203 | uM | 0.00278 | 0.00465 | -0.8411 | -0.8434 | 1.9229 | 1.3693 | 0.9990 | 1.5445 | |
| AU565 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 14817.203 | uM | 0.00278 | 0.00465 | -0.8411 | -0.8434 | 1.9229 | 1.3693 | 0.9990 | 1.5445 | |
| EFM-192A | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 15284.203 | uM | 0.00168 | 0.00434 | -0.7916 | -0.8337 | 1.0336 | 1.3674 | 0.9953 | 0.6980 | |
| EFM-192A | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 15284.203 | uM | 0.00168 | 0.00434 | -0.7916 | -0.8337 | 1.0336 | 1.3674 | 0.9953 | 0.6980 | |
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 10643.087 | uM | 0.00172 | 0.00488 | -1.0000 | -0.9991 | 1.0559 | 1.3640 | 0.9987 | 0.6516 |