Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
184A1	NM	Basal	Bortezomib	Proteasome	Proteasome	5894.074	uM	0.03715	0.13270	-0.6899	-0.6765	0.6722	0.9059	0.9559	1.4541
184A1	NM	Basal	AG1024	IGF1R	RTK	5894.066	uM	0.20895	0.19857	0.0442	0.1124	5.0000	0.3444	0.9895	1.5027
184A1	NM	Basal	PS-1145	IKK	NFKB	5894.065	uM	inf	416.61250	0.8384	0.8383	4.9997	-0.0087	0.7490	1.6064
184A1	NM	Basal	GSK1838705A	IGF1R	RTK	5895.098	uM	0.42849	0.39937	0.0166	0.0538	1.6165	0.3574	0.9937	1.4041
184A1	NM	Basal	Sirolimus	MTOR	MTOR	7787.068	uM	inf	inf	-0.2794	-0.2794	0.0000	0.5821	0.4995	0.9562
184A1	NM	Basal	Sorafenib	PDGFR/VEGFR/KIT/FLT3	RTK	5895.085	uM	1.60350	2.04080	-0.6352	-0.4548	2.6820	0.5481	0.9684	1.4396
184A1	NM	Basal	Sunitinib	PDGFR/VEGFR/KIT/FLT3	RTK	5894.067	uM	4.440	8.19730	-0.9413	-0.9957	1.7870	0.4582	0.9949	1.5647
184A1	NM	Basal	Sunitinib	PDGFR/VEGFR/KIT/FLT3	RTK	5895.067	uM	5.42490	7.97390	-0.9135	-0.9079	2.6878	0.4188	0.9982	1.4053
184A1	NM	Basal	GSK1838705A	IGF1R	RTK	5894.098	uM	0.36902	0.35227	0.0333	0.0487	2.2061	0.3782	0.9970	1.6523
184A1	NM	Basal	Sorafenib	PDGFR/VEGFR/KIT/FLT3	RTK	5894.084	uM	3.93680	6.19440	-0.5995	-0.4573	1.4330	0.5586	0.9851	1.5903
184A1	NM	Basal	Dichloroacetate	PDK	PDK	12684.176	uM	inf	inf	0.9148	0.9148	0.0000	0.0449	0.1851	1.3650
184A1	NM	Basal	TAPI-0	TACE/Collagenase		5895.096	uM	inf	6.62580	0.8804	0.8803	5.0000	-0.0065	0.5959	1.4232
184A1	NM	Basal	GSK461364	PLK1	PLK	9047.001	uM	4.15810	52.44110	-0.0073	-1.0000	0.4334	0.2620	0.7464	0.7701
184A1	NM	Basal	Bortezomib	Proteasome	Proteasome	5894.074	uM	0.03715	0.13270	-0.6899	-0.6765	0.6722	0.9059	0.9559	1.4541
184A1	NM	Basal	Taxol	TUBB	TUBB	9047.002	uM	0.05134	0.13706	-0.1958	-0.2758	0.4473	0.5388	0.9220	0.5243
184A1	NM	Basal	GSK461364	PLK1	PLK	10002.001	uM	6.06620	9.11620	-0.9717	-1.0000	2.6972	0.2605	0.9735	0.5372
184A1	NM	Basal	Taxol	TUBB	TUBB	12684.002	uM	inf	0.01616	0.4397	0.5237	1.5161	0.2820	0.9561	1.5245
184A1	NM	Basal	Taxol	TUBB	TUBB	10002.002	uM	0.03993	0.01744	0.3992	0.4147	2.1347	0.3380	0.9787	0.9502
184A1	NM	Basal	Disulfiram	Proteasome	Proteasome	12684.174	uM	14.63270	13.50790	0.1987	0.0386	1.0041	0.1179	0.9898	1.4645
184A1	NM	Basal	GSK923295	CENPE	Kinesin	9047.001	uM	inf	inf	0.0385	0.0385	0.0000	0.2510	0.5226	0.7701
184A1	NM	Basal	TCS 2312	CHK1	CHK	12509.152	uM	0.52576	0.68654	-0.6028	-0.3929	2.1732	0.3972	0.9705	1.3755
184A1	NM	Basal	AG1024	IGF1R	RTK	5895.066	uM	0.19048	0.25224	-0.2007	-0.1853	1.1224	0.4351	0.9959	1.1612
184A1	NM	Basal	Bosutinib	Src	nRTK	12509.17	uM	0.45547	0.47009	-0.0739	-0.0269	1.6575	0.3664	0.9494	1.3955
184A1	NM	Basal	TCS PIM-1 1	Pim kinase	PIM	12509.135	uM	11.05020	2.4860	0.3652	0.3169	0.6733	0.2265	0.9787	1.3717
184A1	NM	Basal	GSK923295	CENPE	Kinesin	10002.001	uM	8.47170	11.6240	-0.9507	-1.0000	3.4729	0.2407	0.9439	0.5372

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)