Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 5911.066 | 1.0135 | 1.0218 | 1.2414 | |
| AU565 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 5900.086 | 1.0220 | 1.0202 | 2.1682 | |
| HCC1419 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7440.066 | 0.9661 | 0.8378 | 0.4073 | |
| HCC2185 | TNBC | Luminal | PD184352 | MEK | MAPK | 0.0000853 | uM | 10996.155 | 0.8912 | 0.6938 | 0.6934 | |
| SUM1315MO2 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 9797.019 | 0.9646 | 0.8583 | 0.4912 | |
| 600MPE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 5898.086 | 1.0013 | 1.0044 | 0.5904 | |
| BT-20 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 5904.087 | 1.0475 | 1.0756 | 1.2506 | |
| HCC1569 | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 0.0000853 | uM | 10872.15 | 0.9255 | 0.9070 | 1.6255 | ||
| SUM229PE | TNBC | - | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7537.066 | 0.9443 | 0.9450 | 2.0549 | |
| BT-549 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 5909.086 | 1.0811 | 1.0614 | 2.5783 | |
| HCC2185 | TNBC | Luminal | PD173074 | FGFR1/3 | RTK | 0.0000853 | uM | 7462.093 | 1.0203 | 1.0929 | 0.4426 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12192.155 | 0.9286 | 0.8106 | 0.7451 | |
| SUM229PE | TNBC | - | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7535.066 | 0.9900 | 0.9744 | 0.7812 | |
| HCC70 | TNBC | Basal A | PD184352 | MEK | MAPK | 0.0000853 | uM | 10873.155 | 0.9467 | 0.9161 | 1.2787 | |
| LY2 | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0000853 | uM | 10816.155 | 1.1008 | 1.2436 | 0.8353 | |
| MCF12A | NM | Basal B | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7490.066 | 0.9861 | 0.9888 | 2.4829 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7492.066 | 1.0616 | 1.0731 | 1.6656 | |
| AU565 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.0000853 | uM | 5900.092 | 1.1072 | 1.0789 | 2.6334 | |
| BT-20 | TNBC | Basal A | Erlotinib | EGFR | ErbB | 0.0000853 | uM | 5904.092 | 1.1326 | 1.2991 | 0.8933 | |
| SK-BR-3 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 9760.024 | 1.0163 | 1.0318 | 1.0234 | |
| UACC-812 | HER2amp | Luminal | Nelfinavir | 0.0000853 | uM | 13078.174 | 0.9839 | 0.9488 | 0.6238 | |||
| HCC70 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12400.165 | 0.9743 | 0.9604 | 1.3057 | |
| ZR-75-1 | HR+ | Luminal | Nelfinavir | 0.0000853 | uM | 12677.174 | 1.0249 | 1.0498 | 0.9992 | |||
| SK-BR-3 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 10127.049 | 1.1065 | 1.3489 | 0.6294 | |
| T47DKBLUC | Unknown | Unknown | Nelfinavir | 0.0000853 | uM | 13070.174 | 0.9897 | 0.9743 | 0.7993 |