Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 167 | uM | 10580.072 | 0.6194 | 0.1478 | 0.8627 | |
| HCC1954 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 7836.016 | 1.0311 | 1.0395 | 1.5669 | ||
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 769 | uM | 7794.017 | 0.5204 | 0.4393 | 1.9851 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 3840 | uM | 7793.035 | 0.2753 | -0.3101 | 1.2119 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 769 | uM | 7793.035 | 0.3331 | -0.1925 | 1.2119 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 0.246 | uM | 7794.017 | 1.0313 | 1.0313 | 1.9851 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 0.0492 | uM | 7794.017 | 1.0597 | 1.0593 | 1.9851 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 1.23 | uM | 7794.017 | 0.8292 | 0.8199 | 1.9851 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 6.15 | uM | 7794.017 | 0.5009 | 0.4119 | 1.9851 | |
| HCC1954 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 7836.016 | 1.0026 | 1.0033 | 1.5669 | ||
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 3840 | uM | 7794.017 | 0.4512 | 0.3394 | 1.9851 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 0.246 | uM | 9035.017 | 1.0707 | 1.0606 | 2.2905 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 0.0492 | uM | 9035.017 | 0.9593 | 0.9640 | 2.2905 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 30.7 | uM | 9035.017 | 0.7514 | 0.7654 | 2.2905 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 6.15 | uM | 9035.017 | 0.9215 | 0.9298 | 2.2905 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 154 | uM | 9035.017 | 0.6113 | 0.6133 | 2.2905 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 769 | uM | 9035.017 | 0.3658 | 0.2893 | 2.2905 | |
| HCC1954 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 7836.016 | 1.0268 | 1.0340 | 1.5669 | ||
| BT-474 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 0.0492 | uM | 9163.03 | 1.0668 | 1.4014 | 0.3535 | |
| BT-474 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 6.15 | uM | 7798.017 | 0.9821 | 0.9747 | 1.4161 | |
| BT-474 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 1.23 | uM | 7798.017 | 0.9764 | 0.9665 | 1.4161 | |
| BT-474 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 154 | uM | 7798.017 | 0.8916 | 0.8444 | 1.4161 | |
| BT-474 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 19200 | uM | 7798.017 | 0.3079 | -0.1296 | 1.4161 | |
| SUM225CWN | HER2amp | Basal A | Bosutinib | Src | nRTK | 0.0064 | uM | 12098.145 | 0.9383 | 0.8738 | 0.9769 | |
| SUM225CWN | HER2amp | Basal A | Bosutinib | Src | nRTK | 0.00128 | uM | 12098.145 | 0.9965 | 0.9929 | 0.9769 |