Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 9972.019 | 0.9720 | 0.9474 | 1.0654 | ||
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 9972.019 | 0.6537 | 0.3419 | 1.0654 | ||
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 9972.019 | 0.8408 | 0.6996 | 1.0654 | ||
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 9972.019 | 1.0596 | 1.1117 | 1.0654 | ||
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 9972.019 | 0.3967 | -0.1602 | 1.0654 | ||
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9972.037 | 0.6239 | 0.2916 | 1.0789 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9972.037 | 0.4702 | -0.0063 | 1.0789 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 9972.037 | 0.4167 | -0.1115 | 1.0789 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 9972.037 | 0.3716 | -0.2010 | 1.0789 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9997.037 | 1.0468 | 1.0755 | 1.2339 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9997.037 | 0.9653 | 0.9436 | 1.2339 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9997.037 | 0.5840 | 0.2933 | 1.2339 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9997.037 | 0.4768 | 0.0973 | 1.2339 | |
| ZR75B | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 11939.143 | 0.9547 | 0.9474 | 1.7414 | |
| ZR75B | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 0.064 | uM | 11939.143 | 0.9755 | 0.9717 | 1.7414 | |
| ZR75B | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 1.6 | uM | 11939.143 | 0.7851 | 0.7405 | 1.7414 | |
| ZR75B | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 8 | uM | 11939.143 | 0.6063 | 0.5004 | 1.7414 | |
| ZR75B | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 1000 | uM | 11939.143 | 0.3653 | 0.1217 | 1.7414 | |
| ZR75B | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 5000 | uM | 11939.143 | 0.3176 | 0.0351 | 1.7414 | |
| ZR75B | HR+ | Luminal | 5-FU | TYMS | TYMS | 0.246 | uM | 9972.017 | 0.7360 | 0.5379 | 1.1666 | |
| ZR75B | HR+ | Luminal | 5-FU | TYMS | TYMS | 1.23 | uM | 9972.017 | 0.9667 | 0.9428 | 1.1666 | |
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 9972.019 | 0.9927 | 0.9863 | 1.0654 | ||
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 9972.019 | 0.8992 | 0.8102 | 1.0654 | ||
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.107 | uM | 11939.158 | 0.8158 | 0.7774 | 1.7251 | |
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.0213 | uM | 11939.158 | 0.8797 | 0.8568 | 1.7251 |