Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 21NT | HER2amp | - | Disulfiram | Proteasome | Proteasome | 0.107 | uM | 13575.174 | 0.9864 | 0.9828 | 1.5845 | |
| 21NT | HER2amp | - | Disulfiram | Proteasome | Proteasome | 2.67 | uM | 13575.174 | 0.9850 | 0.9810 | 1.5845 | |
| 21NT | HER2amp | - | Disulfiram | Proteasome | Proteasome | 13.3 | uM | 13575.174 | 0.9277 | 0.9074 | 1.5845 | |
| MCF 10F | NM | - | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 9566.132 | 0.7796 | 0.8030 | 2.4013 | ||
| MCF 10F | NM | - | Disulfiram | Proteasome | Proteasome | 0.0213 | uM | 13750.174 | 0.9693 | 0.9568 | 1.4282 | |
| MCF 10F | NM | - | Disulfiram | Proteasome | Proteasome | 0.533 | uM | 13750.174 | 0.7931 | 0.7003 | 1.4282 | |
| MCF 10F | NM | - | Disulfiram | Proteasome | Proteasome | 2.67 | uM | 13750.174 | 0.9257 | 0.8947 | 1.4282 | |
| MCF 10F | NM | - | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 9566.132 | 1.0335 | 1.0276 | 2.4013 | ||
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 0.000171 | uM | 13009.174 | 0.9835 | 0.9765 | 1.4104 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 0.00427 | uM | 13009.174 | 0.9977 | 0.9967 | 1.4104 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 0.0213 | uM | 13009.174 | 1.0044 | 1.0062 | 1.4104 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 13.3 | uM | 13009.174 | 0.7431 | 0.6204 | 1.4104 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 66.7 | uM | 13009.174 | 0.0121 | -0.9124 | 1.4104 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 0.000853 | uM | 13062.174 | 0.9700 | 0.9639 | 1.6688 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 0.00427 | uM | 13062.174 | 0.9747 | 0.9695 | 1.6688 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 0.533 | uM | 13062.174 | 0.9808 | 0.9768 | 1.6688 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 2.67 | uM | 13062.174 | 0.9803 | 0.9762 | 1.6688 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 66.7 | uM | 13062.174 | 0.9608 | 0.9527 | 1.6688 | |
| SUM229PE | TNBC | - | Methylglyoxal | 17.3 | uM | 13201.184 | 0.9599 | 0.9394 | 1.3314 | |||
| MCF 10F | NM | - | Docetaxel | TUBB | TUBB | 2 | uM | 9566.002 | 0.3244 | 0.1697 | 2.0986 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 0.000171 | uM | 14191.189 | 0.9714 | 0.9806 | 2.9704 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 0.000853 | uM | 14191.189 | 0.9867 | 0.9910 | 2.9704 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 0.00427 | uM | 14191.189 | 0.9777 | 0.9849 | 2.9704 | |
| SUM229PE | TNBC | - | Taxol | TUBB | TUBB | 1.33 | uM | 13062.002 | 0.3413 | 0.0413 | 1.6470 | |
| SUM229PE | TNBC | - | Taxol | TUBB | TUBB | 0.267 | uM | 13062.002 | 0.3247 | 0.0103 | 1.6470 |