Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | 5-FU | TYMS | TYMS | 769 | uM | 9118.017 | 0.2991 | -0.3733 | 1.0401 | |
| 600MPE | HR+ | Luminal | 5-FU | TYMS | TYMS | 154 | uM | 9118.017 | 0.7039 | 0.4271 | 1.0401 | |
| 600MPE | HR+ | Luminal | 5-FU | TYMS | TYMS | 3840 | uM | 9118.017 | 0.0465 | -0.8954 | 1.0401 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 1.23 | uM | 7793.035 | 0.7495 | 0.5765 | 1.2119 | |
| 600MPE | HR+ | Luminal | 5-FU | TYMS | TYMS | 1.23 | uM | 9118.017 | 0.9097 | 0.8261 | 1.0401 | |
| 600MPE | HR+ | Luminal | 5-FU | TYMS | TYMS | 0.246 | uM | 9118.017 | 1.0269 | 1.0516 | 1.0401 | |
| 600MPE | HR+ | Luminal | 5-FU | TYMS | TYMS | 6.15 | uM | 9118.017 | 0.8801 | 0.7690 | 1.0401 | |
| 600MPE | HR+ | Luminal | 5-FU | TYMS | TYMS | 30.7 | uM | 9118.017 | 0.8032 | 0.6201 | 1.0401 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 6.15 | uM | 7793.035 | 0.7079 | 0.5040 | 1.2119 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 0.246 | uM | 9035.017 | 1.0707 | 1.0606 | 2.2905 | |
| BT-483 | HR+ | Luminal | 5-FU | TYMS | TYMS | 769 | uM | 7801.035 | 0.5638 | -0.3043 | 0.5427 | |
| BT-483 | HR+ | Luminal | 5-FU | TYMS | TYMS | 3840 | uM | 7801.035 | 0.3871 | -0.6521 | 0.5427 | |
| BT-483 | HR+ | Luminal | 5-FU | TYMS | TYMS | 19200 | uM | 7801.035 | 0.2651 | -0.8268 | 0.5427 | |
| HCC2185 | TNBC | Luminal | 5-FU | TYMS | TYMS | 6.15 | uM | 7846.017 | 1.0840 | 1.5352 | 0.3403 | |
| 600MPE | HR+ | Luminal | 5-FU | TYMS | TYMS | 0.0492 | uM | 9118.017 | 1.0015 | 1.0028 | 1.0401 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 19200 | uM | 9047.017 | 0.1196 | -0.8384 | 0.8440 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 3840 | uM | 9047.017 | 0.1150 | -0.8459 | 0.8440 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 769 | uM | 9047.017 | 0.1559 | -0.7788 | 0.8440 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 154 | uM | 9047.017 | 0.4338 | -0.2566 | 0.8440 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 30.7 | uM | 9047.017 | 0.9094 | 0.7871 | 0.8440 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 6.15 | uM | 9047.017 | 0.8400 | 0.6268 | 0.8440 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 1.23 | uM | 9047.017 | 1.0292 | 1.0694 | 0.8440 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 0.246 | uM | 9047.017 | 0.9547 | 0.8932 | 0.8440 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 0.0492 | uM | 9047.017 | 0.9725 | 0.9350 | 0.8440 | |
| HCC2185 | TNBC | Luminal | 5-FU | TYMS | TYMS | 30.7 | uM | 7846.017 | 1.0465 | 1.2856 | 0.3403 |