Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Nelfinavir | 0.267 | uM | 12989.174 | 0.9840 | 0.9551 | 0.7084 | |||
| HCC38 | TNBC | Basal B | Methylglyoxal | 10800 | uM | 13635.184 | 0.0462 | -0.7403 | 1.5062 | |||
| MDA-MB-361 | HER2amp | Luminal | Nelfinavir | 6.67 | uM | 13558.174 | 0.9245 | 0.7427 | 0.5699 | |||
| MDA-MB-415 | HR+ | Luminal | Nelfinavir | 0.000427 | uM | 12959.174 | 0.9436 | 0.7815 | 0.5020 | |||
| MDA-MB-415 | HR+ | Luminal | Nelfinavir | 0.0107 | uM | 12959.174 | 0.9804 | 0.9227 | 0.5020 | |||
| MDA-MB-415 | HR+ | Luminal | Nelfinavir | 6.67 | uM | 12959.174 | 0.8191 | 0.3438 | 0.5020 | |||
| MDA-MB-415 | HR+ | Luminal | Nelfinavir | 0.0000853 | uM | 13587.174 | 0.9890 | 0.9684 | 0.6955 | |||
| MDA-MB-415 | HR+ | Luminal | Nelfinavir | 0.00213 | uM | 13587.174 | 0.9959 | 0.9881 | 0.6955 | |||
| MDA-MB-415 | HR+ | Luminal | Nelfinavir | 6.67 | uM | 13587.174 | 0.7971 | 0.4435 | 0.6955 | |||
| MDA-MB-453 | TNBC | Luminal | Nelfinavir | 0.000427 | uM | 12964.174 | 0.9755 | 0.9382 | 0.7885 | |||
| MDA-MB-453 | TNBC | Luminal | Nelfinavir | 0.0107 | uM | 12964.174 | 0.9829 | 0.9567 | 0.7885 | |||
| MDA-MB-453 | TNBC | Luminal | Nelfinavir | 0.267 | uM | 12964.174 | 0.9397 | 0.8483 | 0.7885 | |||
| MDA-MB-453 | TNBC | Luminal | Nelfinavir | 6.67 | uM | 12964.174 | 0.6836 | 0.2345 | 0.7885 | |||
| MDA-MB-453 | TNBC | Luminal | Nelfinavir | 0.000427 | uM | 13562.174 | 0.9987 | 0.9965 | 0.7219 | |||
| MDA-MB-453 | TNBC | Luminal | Nelfinavir | 0.0107 | uM | 13562.174 | 0.9948 | 0.9856 | 0.7219 | |||
| MDA-MB-453 | TNBC | Luminal | Nelfinavir | 33.3 | uM | 13562.174 | 0.6623 | 0.1303 | 0.7219 | |||
| MX1 | Unknown | Unknown | Nelfinavir | 0.000427 | uM | 12667.174 | 1.0194 | 1.0478 | 0.8129 | |||
| MX1 | Unknown | Unknown | Nelfinavir | 0.0107 | uM | 12667.174 | 1.0174 | 1.0429 | 0.8129 | |||
| MX1 | Unknown | Unknown | Nelfinavir | 6.67 | uM | 12667.174 | 0.8112 | 0.5460 | 0.8129 | |||
| SK-BR-3 | HER2amp | Luminal | Nelfinavir | 0.000427 | uM | 12999.174 | 0.9907 | 0.9775 | 0.8315 | |||
| SK-BR-3 | HER2amp | Luminal | Nelfinavir | 0.0533 | uM | 12999.174 | 0.9594 | 0.9026 | 0.8315 | |||
| SUM149PT | TNBC | Basal B | Nelfinavir | 0.00213 | uM | 13123.174 | 0.9675 | 0.9375 | 1.0408 | |||
| SUM149PT | TNBC | Basal B | Nelfinavir | 0.0533 | uM | 13123.174 | 1.0836 | 1.1605 | 1.0408 | |||
| SUM149PT | TNBC | Basal B | Nelfinavir | 1.33 | uM | 13123.174 | 0.9922 | 0.9849 | 1.0408 | |||
| SUM149PT | TNBC | Basal B | Nelfinavir | 33.3 | uM | 13123.174 | 0.0029 | -0.9926 | 1.0408 |