Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7473.066 | 1.0043 | 1.0037 | 2.3582 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7793.001 | 1.0185 | 1.0321 | 1.1508 | |
| SUM149PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10819.149 | 1.0238 | 1.0231 | 2.0505 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 10441.087 | 1.0538 | 1.1092 | 0.9863 | |
| HCC1937 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7453.086 | 1.0417 | 1.0582 | 1.4238 | |
| HCC1395 | TNBC | Basal B | GM6001 | MMP | MMP | 0.0000853 | uM | 7436.096 | 0.9074 | 0.8657 | 1.3979 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9953.001 | 0.9803 | 0.8855 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9933.001 | 0.9288 | 0.7001 | 0.4544 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7931.001 | 0.9845 | 0.9760 | 1.2900 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9045.001 | 1.0160 | 1.0330 | 0.9719 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7932.001 | 1.0544 | 1.1060 | 1.0256 | |
| HCC1187 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 10518.087 | 1.0624 | 1.1064 | 1.1688 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.0000853 | uM | 10872.154 | 0.9962 | 0.9946 | 1.3976 | |
| BT-483 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 5908.066 | 0.9086 | 0.6199 | 0.4546 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9958.001 | 0.9997 | 0.9988 | 0.5164 | |
| T47DKBLUC | Unknown | Unknown | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7544.066 | 1.0052 | 1.0095 | 1.0898 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 10267.001 | 1.0129 | 1.0657 | 0.3957 | |
| HCC1187 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7431.087 | 1.0406 | 1.0573 | 1.4117 | |
| HCC1187 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 10753.087 | 0.9856 | 0.9795 | 1.4150 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9913.001 | 1.1080 | 1.8001 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7926.001 | 1.0949 | 1.2449 | 0.7852 | |
| ZR75B | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9972.001 | 1.0017 | 1.0032 | 1.0521 | |
| HCC1143 | TNBC | Basal A | GM6001 | MMP | MMP | 0.0000853 | uM | 7430.096 | 0.9352 | 0.9346 | 2.0162 | |
| T47D | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9897.001 | 0.9980 | 0.9925 | 0.5223 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 10150.001 | 1.0545 | 1.3539 | 0.3255 |