Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9146.122 | 1.0623 | 1.0922 | 1.3408 | |
| HCC38 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7854.018 | 0.9524 | 0.9222 | 1.2298 | |
| BT-20 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 5903.102 | 1.0014 | 1.0023 | 1.2557 | |
| HCC1428 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7441.102 | 1.0118 | 1.0257 | 0.9144 | |
| BT-474 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9158.123 | 1.0183 | 1.0418 | 0.8769 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7803.042 | 1.0067 | 1.0048 | 2.8270 | |
| BT-474 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9163.026 | 1.0046 | 1.0246 | 0.3738 | |
| HCC70 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7860.042 | 1.0026 | 1.0078 | 0.6736 | |
| BT-483 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7801.018 | 0.9888 | 0.9622 | 0.5913 | |
| HCC1419 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 10019.124 | 1.0767 | 1.2958 | 0.5356 | |
| BT-483 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9186.026 | 1.1176 | 1.4864 | 0.5108 | |
| Hs 578T | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7863.018 | 1.0001 | 1.0001 | 2.0946 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7804.042 | 1.0020 | 1.0016 | 2.4955 | |
| CAMA-1 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9210.026 | 1.0106 | 1.0232 | 0.9102 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9024.018 | 1.0036 | 1.0026 | 2.8306 | |
| HCC1428 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9294.125 | 1.0092 | 1.0262 | 0.6999 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 10261.026 | 1.0471 | 1.0374 | 2.4866 | |
| LY2 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 10264.026 | 0.9732 | 0.9642 | 1.5047 | |
| CAMA-1 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7805.018 | 1.0531 | 1.0924 | 1.1451 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7429.102 | 1.0214 | 1.0174 | 2.4347 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7808.052 | 0.9898 | 0.9917 | 2.4842 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7807.042 | 1.0293 | 1.0287 | 2.0250 | |
| HCC1143 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7809.018 | 0.9887 | 0.9865 | 1.6742 | |
| MDA-MB-361 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7895.018 | 1.0127 | 1.0196 | 1.2916 | |
| MDA-MB-231 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7893.042 | 0.8032 | 0.8167 | 2.2789 |