Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7845.018 | 0.7630 | 0.0991 | 0.4518 | |
| MCF12A | NM | Basal B | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7873.042 | 0.3678 | 0.2674 | 2.1928 | |
| HCC2185 | TNBC | Luminal | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7848.042 | 0.8172 | 0.2306 | 0.4157 | |
| AU565 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 9.27 | uM | 9035.018 | 0.1244 | -0.2396 | 2.1555 | |
| BT-474 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7798.018 | 0.2955 | -0.1392 | 1.4461 | |
| SUM159PT | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7920.018 | 0.0683 | 0.0826 | 4.3723 | |
| MDA-MB-175-VII | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7885.042 | 0.4633 | -0.4557 | 0.5912 | |
| HCC1569 | HER2amp | Basal A | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7824.018 | 0.2930 | -0.2156 | 1.3115 | |
| HCC1419 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7818.018 | 0.5805 | 0.1564 | 0.9928 | |
| MDA-MB-175-VII | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7886.042 | 0.5361 | -0.2378 | 0.6462 | |
| MDA-MB-361 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7896.042 | 0.4171 | -0.0569 | 1.1632 | |
| SUM159PT | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9.27 | uM | 9042.018 | 0.0491 | -0.2093 | 3.2484 | |
| MDA-MB-436 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7900.018 | 0.3252 | -0.4829 | 0.8304 | |
| HCC3153 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7853.042 | 0.3806 | 0.1561 | 1.7624 | |
| Hs 578T | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7863.018 | 0.0414 | -0.5629 | 2.0946 | |
| HCC1569 | HER2amp | Basal A | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7825.018 | 0.2233 | -0.0642 | 1.9741 | |
| Hs 578T | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7864.042 | 0.0479 | -0.7429 | 1.4812 | |
| HCC1806 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7829.042 | 0.1166 | -0.3673 | 1.8673 | |
| SUM185PE | TNBC | Luminal | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7921.042 | 0.3171 | -0.6718 | 0.6355 | |
| HCC1937 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7833.042 | 0.5657 | 0.1522 | 1.0332 | |
| HBL-100 | Unknown | Unknown | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7808.052 | 0.0504 | -0.3990 | 2.4842 | |
| MDA-MB-231 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7892.018 | 0.3124 | 0.2535 | 2.4903 | |
| BT-549 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7803.042 | 0.1324 | -0.0219 | 2.8270 | |
| MCF 10A | NM | Basal B | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7868.018 | 0.2058 | -0.0541 | 2.1110 | |
| SUM52PE | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 92.7 | uM | 9878.006 | 0.0242 | -0.8608 | 1.3968 |