Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 10267.121 | 0.5450 | -0.5391 | 0.4135 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 85.2 | uM | 9566.121 | 0.3098 | 0.2040 | 2.3089 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 85.2 | uM | 7491.078 | 0.2526 | -0.7011 | 0.7238 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 85.2 | uM | 10061.121 | 0.1618 | -0.2192 | 1.9364 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 9583.121 | 0.2259 | -0.5055 | 1.0648 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 85.2 | uM | 7879.077 | 0.0624 | -0.5525 | 1.8534 | |
| SUM52PE | HR+ | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 7540.078 | 0.0571 | -0.9011 | 0.9523 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 9759.121 | 0.0880 | -0.6968 | 1.2887 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 9972.121 | 0.6137 | 0.2849 | 1.1034 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 9997.121 | 0.6581 | 0.3728 | 1.1121 | |
| AU565 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 9146.121 | 0.1477 | -0.6284 | 1.1366 | |
| BT-474 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 7798.077 | 0.9208 | 0.8883 | 1.4371 | |
| MDA-MB-453 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 10270.121 | 0.2090 | -0.7011 | 0.8235 | |
| BT-549 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 85.2 | uM | 10261.121 | 0.0188 | -0.6572 | 2.2540 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 85.2 | uM | 10266.121 | 0.3665 | -0.5125 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 85.2 | uM | 7899.077 | 0.3017 | 0.1579 | 2.1925 | |
| LY2 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 10264.121 | 0.1524 | -0.4963 | 1.3643 | |
| MDA-MB-415 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 9664.121 | 0.1786 | -0.8115 | 0.7294 | |
| HBL-100 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 86.2 | uM | 9226.034 | 0.0019 | -0.8190 | 2.6175 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7872.007 | 2.4960 | 2.4119 | 1.7126 | |
| Hs 578T | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7863.007 | 0.1096 | -0.5612 | 1.4578 | |
| HMT-3522 S1 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7911.007 | 0.1173 | -0.4958 | 1.5549 | |
| HCC1395 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7816.007 | 1.5915 | 1.9920 | 1.1536 | |
| HBL-100 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7808.043 | 0.1187 | -0.1800 | 2.3907 | |
| ZR-75-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 9958.034 | 0.0102 | -0.9997 | 0.5217 |