Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 0.000171 | uM | 12084.16 | 1.0124 | 1.0222 | 1.1178 | ||
| HCC38 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 0.000171 | uM | 10578.145 | 0.9413 | 0.9291 | 1.6766 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7443.098 | 0.9737 | 0.9428 | 0.9189 | |
| 600MPE | HR+ | Luminal | IKK16 | IKK | NFKB | 0.000171 | uM | 5898.093 | 0.9713 | 0.9181 | 0.6963 | |
| BT-474 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 0.000171 | uM | 12056.16 | 0.9812 | 0.9588 | 0.9124 | ||
| BT-474 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12056.135 | 0.9282 | 0.8469 | 0.9361 | |
| HCC1937 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7453.098 | 1.0240 | 1.0326 | 1.4660 | |
| ZR-75-1 | HR+ | Luminal | IKK16 | IKK | NFKB | 0.000171 | uM | 7553.093 | 0.9699 | 0.9472 | 1.1429 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 10380.092 | 1.0346 | 1.0462 | 1.4888 | |
| UACC-812 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 0.000171 | uM | 11938.145 | 0.9260 | 0.7938 | 0.7062 | |
| MDA-MB-453 | TNBC | Luminal | Glycyl-H-1152 | ROCK2 | 0.000171 | uM | 12414.169 | 0.9812 | 0.9665 | 1.1235 | ||
| SUM159PT | TNBC | Basal B | IKK16 | IKK | NFKB | 0.000171 | uM | 7531.093 | 0.9863 | 0.9924 | 3.5995 | |
| MDA-MB-415 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7511.098 | 0.9902 | 0.9837 | 1.2032 | |
| SUM149PT | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 0.000171 | uM | 10819.145 | 0.9808 | 0.9824 | 2.1971 | |
| CAMA-1 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 5912.098 | 0.9849 | 0.9714 | 1.0559 | |
| SUM229PE | TNBC | - | IKK16 | IKK | NFKB | 0.000171 | uM | 7535.1 | 1.0235 | 1.0538 | 0.8740 | |
| UACC-812 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7547.098 | 0.9335 | 0.8720 | 1.0399 | |
| HCC38 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 0.000171 | uM | 10578.145 | 0.9413 | 0.9291 | 1.6766 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7454.092 | 0.9021 | 0.8405 | 1.2402 | |
| SUM225CWN | HER2amp | Basal A | IKK16 | IKK | NFKB | 0.000171 | uM | 10579.1 | 0.9689 | 0.9357 | 0.9677 | |
| BT-474 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 0.000171 | uM | 12291.169 | 1.0303 | 1.1753 | 0.3548 | ||
| HCC1806 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 0.000171 | uM | 14634.189 | 0.9490 | 0.9520 | 2.1561 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 5906.098 | 1.0148 | 1.0369 | 0.8050 | |
| SUM159PT | TNBC | Basal B | IKK16 | IKK | NFKB | 0.000171 | uM | 10520.1 | 0.9743 | 0.9856 | 3.6151 | |
| SUM229PE | TNBC | - | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7535.092 | 1.0332 | 1.0588 | 1.1267 |