Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7807.042 | 1.0293 | 1.0287 | 2.0250 | |
| BT-483 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7801.018 | 0.9888 | 0.9622 | 0.5913 | |
| BT-483 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9186.026 | 1.1176 | 1.4864 | 0.5108 | |
| HCC1569 | HER2amp | Basal A | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9347.026 | 1.0302 | 1.0465 | 1.2965 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7803.042 | 1.0067 | 1.0048 | 2.8270 | |
| 184A1 | NM | Basal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7787.018 | 1.1731 | 2.0469 | 0.3791 | |
| 184B5 | NM | Basal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9095.026 | 1.2784 | 1.5465 | 1.0168 | |
| 184A1 | NM | Basal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9047.026 | 0.9014 | 0.6810 | 0.5972 | |
| BT-474 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7798.018 | 1.0352 | 1.0485 | 1.4461 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9024.018 | 1.0036 | 1.0026 | 2.8306 | |
| 600MPE | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7791.018 | 1.0127 | 1.0298 | 0.8558 | |
| HCC1187 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7811.018 | 1.0097 | 1.0414 | 0.4694 | |
| 600MPE | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9118.006 | 0.9876 | 0.9776 | 1.1089 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7793.018 | 0.9920 | 0.9878 | 1.3186 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9035.018 | 1.0285 | 1.0263 | 2.1555 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7794.018 | 1.4132 | 1.4568 | 1.6812 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 10261.026 | 1.0471 | 1.0374 | 2.4866 | |
| HCC1395 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9258.026 | 1.0214 | 1.0765 | 0.5632 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9146.122 | 1.0623 | 1.0922 | 1.3408 | |
| CAMA-1 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7805.018 | 1.0531 | 1.0924 | 1.1451 | |
| BT-20 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 5903.102 | 1.0014 | 1.0023 | 1.2557 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7429.102 | 1.0214 | 1.0174 | 2.4347 | |
| BT-474 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9158.123 | 1.0183 | 1.0418 | 0.8769 | |
| HCC1937 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7833.042 | 0.9237 | 0.8521 | 1.0332 | |
| HCC1937 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7832.042 | 1.0048 | 1.0075 | 1.2810 |