Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 565 | uM | 7515.092 | 0.0089 | -0.9604 | 1.2024 | |
| HCC38 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 46.4 | uM | 7854.018 | 0.0080 | -0.9604 | 1.2298 | |
| SUM1315MO2 | TNBC | Basal B | Torkinib | 50 | uM | 15401.211 | 0.2021 | -0.9603 | 0.4079 | |||
| MDA-MB-157 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 66.7 | uM | 12594.17 | 0.0084 | -0.9603 | 1.2180 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 9278.037 | 0.2236 | -0.9603 | 0.3822 | |
| MDA-MB-157 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 66.7 | uM | 12594.17 | 0.0084 | -0.9603 | 1.2180 | |
| MDA-MB-175-VII | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 2.67 | uM | 10642.145 | 0.2502 | -0.9602 | 0.3537 | |
| T47DKBLUC | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 40 | uM | 7545.065 | 0.0215 | -0.9602 | 0.9803 | |
| MDA-MB-175-VII | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 2.67 | uM | 10642.145 | 0.2502 | -0.9602 | 0.3537 | |
| CAMA-1 | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 66.7 | uM | 12070.158 | 0.0122 | -0.9601 | 1.1252 | |
| HCC1187 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7433.098 | 0.0116 | -0.9600 | 1.1392 | |
| 184B5 | NM | Basal | Disulfiram | Proteasome | Proteasome | 66.7 | uM | 12979.174 | 0.0022 | -0.9600 | 1.5680 | |
| HCC1395 | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 565 | uM | 7436.091 | 0.0076 | -0.9599 | 1.2489 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9723.001 | 0.0254 | -0.9598 | 0.9400 | |
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 33.3 | uM | 10816.15 | 0.3061 | -0.9598 | 0.3031 | ||
| HCC38 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 1000 | uM | 10418.065 | 0.0255 | -0.9596 | 0.9401 | |
| ZR-75-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 167 | uM | 12003.159 | 0.0077 | -0.9596 | 1.2466 | |
| HCC70 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7470.085 | 0.0212 | -0.9596 | 0.9880 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12070.159 | 0.0215 | -0.9595 | 0.9846 | |
| SUM149PT | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 13.3 | uM | 14284.189 | 0.0045 | -0.9595 | 1.3873 | |
| SUM52PE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 565 | uM | 7541.091 | 0.0041 | -0.9595 | 1.4119 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 12379.155 | 0.2281 | -0.9594 | 0.3793 | |
| MDA-MB-157 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 13.3 | uM | 12594.17 | 0.0087 | -0.9594 | 1.2180 | |
| MDA-MB-157 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 13.3 | uM | 12594.17 | 0.0087 | -0.9594 | 1.2180 | |
| BT-20 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 66.7 | uM | 14821.203 | 0.0111 | -0.9593 | 1.1544 |